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The globally marketed Aciphex Pariet U.S. brand name: Aciphex ; is a PPI for the treatment of gastric acid-related disorders. It was first launched in 1997, is now available in 72 countries, and boasted sales in regions where Eisai markets the drug of 132.3 billion 24.8% of net sales ; in the fiscal year ended March 31, 2005. Market research indicates that the global market for treatments of gastric acid-related disorders stands at about .5 billion, ranking it as the 2nd largest therapeutic area in terms of product sales. PPIs account for about 80% of the total market, and prescription numbers are growing each year as the patient population increases and as those using other medications switch to PPIs. In the United States, which accounts for about 60% of global sales, competition in the PPI market is increasing with the entry of generic PPIs and an OTC PPI product. To secure its market position, Eisai has been promoting Aciphex's fast symptom relief and stable healing power. Unlike in Europe and the United States, the Japanese market for PPIs accounts for a low percentage of prescriptions to treat gastric acid-related disorders; thus, there is substantial potential for growth in Japan. In China, we expect prescriptions for Pariet to increase in the fiscal year ending March 31, 2006, particularly as it has been listed on the formulary of the Chinese national health system and drug costs are reimbursed by the government. Besides Aciphex Pariet, Eisai's line of gastroenterology products also includes.
FIG.5. Dephosphorylation of [A~n~~]lysozyme fragment of the fusion protein. The fusion protein was immunoprecipitated with a 1: l mixture of affinity-purified anti-lysozyme and anti-cathepsin D antibodies from the medium of the transfected CHO cells that were metabolically labeled with [32P]phosphate or Tran"S-Label in the presence of 10 mM NHIC1. The immunoprecipitates were incubated with cathepsin L for 15 min. After a precipitation withacetone aliquots were prepared and incubated without - ; or with 6.2 units + ; or 12.5 units + ; alkaline phosphatase as indicated A P ; . The fluorogram shows the radioactivity associated with the [AsnZz]lysozyme fragment. LC refers to a form bearing a complex type oligosaccharide and LH to a form bearing a phosphorylated high mannose oligosaccharide. Asmall amount of nonglycosylated form is also visible L.
FIG. 6. Effect of PC-saturated fatty acid chain length on Incubations were carried out with 2.5 pg of solubilized microsomal enzyme under the conditions described in the legend to Fig. 5. The following PC derivatives were tested: dicaproyl 6 dioctanoyl 8 didecanoyl 10 dilauroyl 12 dimyristoyl 1 4 dipalmitoyl 16 and distearoyl 18.
Course of treatment received by depressed patients. Journal of Psychiatric Research, 33, 233 242. Research, 33.
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Welcome to IFJ Asia's monthly bulletin. The next bulletin will be sent on Friday 1 August 2003 and contributions from affiliates are most welcome. To contribute, email ifj ifj-asia In this bulletin: Calls for support against Hong Kong's Article 23 Press freedom deteriorates in Indonesia Calls for support for Sri Lankan journalist receiving death threats IFJ Child Rights and the Media Asia meeting in Bangkok and workshops in Cambodia Trade union organising training in the Philippines 2003 Alfred Friendly Fellows Latest protests Calls for support against Hong Kong's Article 23 IFJ Asia is calling on all IFJ Asian affiliates to support the Hong Kong Journalists' Association's HKJA ; opposition to the Hong Kong Government's proposed Article 23 by writing letters of protest to the Hong Kong Government by Tuesday 8 July. The IFJ and HKJA are particularly concerned about aspects of Article 23, particularly: Laws on sedition, particularly the extension of the law so that all permanent residents could be prosecuted for what they say in an out of Hong Kong. Laws regarding theft of state secrets, especially the fact that there is no provision for defence in the case of public interest and when the matter has already been made public by others. The broad definition of `seditious publications'. The removal of the six-month time limited on bringing prosecutions against sedition. The wide-ranging powers given to the Secretary of Security to ban local and foreign political organisations. The increase in enforcement powers, including exemptions for the police to get a warrant to enter private premises, search and seizure; the ability of police to force financial institutions to divulge confidential client information without a warrant; the harsh penalties for many Article 23 offences, including life imprisonment. The HKJA, the IFJ's affiliate in Hong Kong, has been co-ordinating a long-running campaign against the proposed legislation, which will be considered for implementation on 9 July. Part of the campaign was the HKJA's involvement in a massive public rally in Hong Kong protesting the legislation on 1 July. The HKJA and IFJ Asia are calling for an extension of the deadline to allow for effective public debate. IFJ Asia urges all Asia affiliates to send a letter by Tuesday 8 July to the Hong Kong Government to jointly express disapproval and concern. A sample letter can be found at: : ifjasia Hong Kong Please copy protest letters to ifj ifj-asia and hkja hk.super and tiagabine.
Consecutive heartbeats after contrast arrival in the right ventricle RV ; , patient with mild pulmonary hypertension pulmonary arterial pressure PAP ; systolic diastolic mean s d m ; 543 20 31 mmHg ; . The x-axis presents heart beat after contrast arrival in the RV. The y-axis presents the magnetic resonance MR ; signal intensity in the anterior and posterior region. b ; Similar perfusion curves in a patient with moderate pulmonary arterial hypertension PAP s d m549 31 40 mmHg ; . &: anterior; &: posterior.
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14. Toda, N., Baba, H. & Okamura, T. 1990 ; Jpn. J. Pharmacol. 53, 281-284. 15. Li, C. G. & Rand, M. J. 1990 ; Eur. J. Pharmacol. 191, 303-309. 16. Boeckxstaens, G. Eb, Pejcknlan$, P., A . Bult, . H., De Man, J. G., Herman, A. G. & Van Maercke, Y. M. 1991 ; Br. J. Pharmnacol.l102, 434-438. 17. Desai, jK. M., Sessa, W. C. & Vane, J. R. 1991 ; Nature London ; 351, 477-479. 18. Meyer, J. H. 1987 ; in Physiology ofthe Gastrointestinal Tract, ed., Johnson, L. R. Raven, New York ; , 2nd Ed., pp. 613-629. 19. Cannon, W. B. & Lieb, C. W. 1911 ; Am. J. Physiol. 29, 267-273. 20. Cannon, W. B. 1898 ; Am. J. Physiol. 1, 359-382. 21. Davenport, H. W. 1971 ; Physiology of the Digestive Tract Year Book Medical, Chicago ; . 22. Abrahamsson, H. 1973 ; Acta Physiol. Scand. Suppl. 390, 1-38. 23. Martinson, J. 1965 ; Acta Physiol. Scand. 64, 453-462. 24. Fahrenkrug, J., Haglund, U., Jodal, M., Lundgren, O., Olbe, 0. & Schaffalitzky de Muckadel, 0. B. 1978 ; J. Physiol. London ; 284, 291-305. 25. Burnstock, G. 1972 ; Pharmacol. Rev. 24, 509-581. 26. Fox, J. A. 1988 ; Gastroenterol. Clin. North Am. 18, 163-177. 27. Rees, D. D., Palmer, R. M. J., Hodson, H. F. & Moncada, S. 1989 ; Br. J. Pharmacol. 96, 418-424. 28. Chung, S. J. & Fung, H. L. 1990 ; J. Pharmacol. Exp. Ther. 253, 614-619. 29. Waldman, S. A. & Murad, F. 1987 ; Pharmacol. Rev. 39, 163-196. 30. Ignarro, L. J. 1989 ; Semin. Hematol. 26, 63-76. 31. Grey, E. G. 1918 ; Am. J. Physiol. 45, 272-285 and ting.
REQUIRED Enter the seven-digit Iowa Medicaid number of the billing provider. If this number identifies a group or an individual provider other than the provider of service, the treating provider's Iowa Medicaid number must be entered in field 24K for each line.
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Induction of interleukin-6 during human immunodeficiency virus infection. Blood 76: 2303, 1990 Gruntfeld C, Kotler DP, Hamadie R, Tierney A, Wang J, Pierson RN Jr: Hypertriglyceridemia in the acquired immunodeficiency syndrome. J Med 86: 27, 1989 Rudman D, Feller AG, Nagraj HS, Gergans GA, Lalitha PY, Goldberg AF, Schlenker RA, Cohn L, Rudman IW, Mattson DE: Effects of human growth hormone in men over 60 years old. N Engl J Med 323: 1, 1990 Torosin MH, Donoway RB: Growth hormone inhibits tumor metastasis. Cancer 67: 2280, 1991 Laurence J, Astrin SM: Human immunodeficiency virus induction of malignant transformation in human B lymphocytes. Proc Natl Acad Sci USA 88: 7653, 1991 Ensoli B, Nakamura S, Salahuddin SZ, Biberfeld P, Larsson L, Beaver B, Wong-Staal F, Gallo RC: AIDS-Kaposi's sarcomaderived cells express cytokines with autocrine and paracrine growth effects. Science 243: 223, 1989 Spencer SA, h u n g DS, Godowski PJ. Hammond RG, Waters MJ, Wood WI: Growth hormone receptor and binding protein. Recent Prog Hormone Res 46: 165, 1990 Weigent DA, Blalock JE: The production of growth hormone by sub-populations of rat mononuclear leukocytes. Cell Immunol135: 55, 1991 27. D'Addario M, Roulston A, Wainberg MA, Hiscott J: Coordinate enhancement of cytokine gene expression in human immunodeficiencyvirus type 1-infected promonocytic cells. J Virol64: 6080, 1990 28. Lowenthal JW, Ballard DW, Bohnlein E, Greene WC: Tumor necrosis factor a induces proteins that bind specifically to kB-like enhancer elements and regulate interleukin 2 receptor a-chain gene expression in primary human T lymphocytes. Proc Natl Acad Sci USA 86: 2331, 1989 Vyakarnam A, Matcar P, Meager A, Kelly G, Stanley B, Weller I, Beverley P: Altered production of tumor necrosis factor.
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Aggarwal R, Ghoshal UC, Naik SR. Assessment of cost-effectiveness of universal hepatitis B immunization in a low-income country with intermediate endemicity using a Markov model. J Heptol 2003; 38: 215-22.
Aureus DNA topoisomerase IV: a primary target of fluoroquinolones. Mol. Microbiol. 13: 641653. Fournier, B., and D. C. Hooper. 1998. Effects of mutations in GrlA of topoisomerase IV from Staphylococcus aureus on quinolone and coumarin activity. Antimicrob. Agents Chemother. 42: 21092112. Janoir C., V. Zeller, M.-D. Kitzis, N. J. Moreau, and L. Gutmann. 1996. High-level fluoroquinolone-resistance in Streptococcus pneumoniae requires mutations in parC and gyrA. Antimicrob. Agents Chemother. 40: 27602764. Jones, M. E., D. F. Sahm, N. Martin, S. Scheuring, P. Heisig, C. Thornsberry, K. Kohrer, and F. J. Schmitz. 2000. Prevalence of gyrA, gyrB, parC, and parE mutations in clinical isolates of Streptococcus pneumoniae with decreased susceptibilities to different fluoroquinolones and originating from Worldwide Surveillance Studies during the 1997-1998 respiratory season. Antimicrob. Agents Chemother. 44: 462466. Jorgensen, J. H., L. M. Weigel, M. J. Ferraro, J. M. Swenson, and F. C. Tenover. 1999. Activities of newer fluoroquinolones against Streptococcus pneumoniae clinical isolates including those with mutations in the gyrA, parC, and parE loci. Antimicrob. Agents Chemother. 43: 329334. Morais Cabral, J. H., A. P. Jackson, C. V. Smith, N. Shikotra, A. Maxwell, and R. C. Liddington. 1997. Crystal structure of the breakage-reunion domain of DNA gyrase. Nature 388: 903906. Munoz, R., and A. G. de Campa. 1996. ParC subunit of DNA topoisomerase IV of Streptococcus pneumoniae is a primary target of fluoroquinolones and cooperates with DNA gyrase A subunit in forming resistance phenotype. Antimicrob. Agents Chemother. 40: 22522257. Munoz, R., M. Bustamante, and A. G. de Campa. 1995. Ser-127-to-Leu substitution in the DNA gyrase B subunit of Streptococcus pneumoniae is implicated in novobiocin resistance. J. Bacteriol. 177: 41664170. Pan, X.-S., and L. M. Fisher. 1996. Cloning and characterization of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV: role in fluoroquinolone resistance. J. Bacteriol. 178: 40604069 and tobi.
Electrophoresed at 200 V using a BioRad MiniProtean II apparatus. Gels were then incubated for 10 min in 25 mM potassium phosphate, pH 7.0, and proteins transferred to 0.2 m nitrocellulose at 40 V for 3 h in potassium phosphate, pH 7.0 26 ; . Subsequent procedures are described elsewhere 24 ; . Anti-mouse IgG-horseradish peroxidase conjugate and anti-rabbit IgG-horseradish peroxidase conjugate were used as the secondary antibodies at a dilution of 1: 10, 000. In order to quantify CaM levels, it was necessary to load different amounts of tissue protein to ensure that the enhanced chemiluminescence signal lay on the linear part of the signal vs protein amount relationship shown to be 0.25 - 12 ng CaM ; . The following loading levels were used for this purpose: 2 l of dilution for pre- and post-KCl-treated intact ; tissues points 1 and 3 in Figure 2 2 l undiluted ; for Triton-treated tissue and following the subsequent Ca2 + -induced contraction points 4 and 5 30 l for all other tissue samples points 6, 8 and 10 ; . Quantification of LC20 Phosphorylation Levels - Proteins were extracted from lyophilized tissue samples and phosphorylated and unphosphorylated LC20 were and thorazine.
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To be eligible for the study, patients had to be more than 18 years of age, to be infected with both HIV and HCV, and to have anti-HCV antibodies in serum, detectable serum levels of HCV RNA 600 IU per milliliter ; , elevated serum alanine aminotransferase levels documented on two or more occasions within the previous 12 months, findings on liver biopsy within the past 15 months that were consistent with the presence of chronic hepatitis C infection, and compensated liver disease without compromise of liver function or clinically important portal hypertension ; . The presence of HIV type 1 HIV-1 ; disease was confirmed by detection of antiHIV-1 antibodies or HIV-1 RNA in serum Amplicor HIV-1 Monitor Test, version 1.5 ; . Patients with CD4 + cell counts of 200 per cubic millimeter or higher were eligible regardless of the HIV RNA level; those with CD4 + cell counts between 100 per cubic millimeter and 199 per cubic millimeter were eligible if their HIV-1 RNA load was less than 5000 copies per milliliter and tolmetin.
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