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Of breast cancer in these patients [2-8]. In this study, we retrospectively reviewed the screening mammograms of a group of asymptomatic women with breast implants.
A person who has used cocaine may experience any of the following symptoms: fast or slow heart rate dilated pupils increased or decreased blood pressure sweating or chills nausea or vomiting weight loss changes in movement either agitated or slowed movement ; muscular weakness slowed breathing chest pain changes in mental state, such as confusion, seizures or coma.
1. Gotlib IH, Whiffen VE, Mount JH, Milne K, Cordy NI. Prevalence rates and demographic characteristics associated with depression in pregnancy and the postpartum. J Clin Consult Psychol 1989; 57: 269274. Orr ST, Miller CA. Maternal depressive symptoms and the risk of poor pregnancy outcome. Review of the literature and preliminary findings. Epidemiol Rev 1995; 17: 165171. Zuckerman B, Amaro H, Bauchner H, Cabral H. Depressive symptoms during pregnancy: relationship to poor health behaviors. J Obstet Gynecol 1989; 160: 11071111. Steer RA, Scholl TO, Hediger ML, Fischer RL. Self-reported depression and negative pregnancy outcomes. J Clin Epidemiol 1992; 45: 10931099. Zuckerman B, Bauchner H, Parker S, Cabral H. Maternal depressive symptoms during pregnancy and newborn irritability. J Dev Behav Pediat 1999; 11: 190194. Fabro SE. Clinical Obstetrics. New York: Wiley, 1987. 7. Eberhard-Gran M, Eskild A, Opjordsmoen S. Treating mood disorders during pregnancy: safety considerations. Drug Saf 2005; 28: 695706. GlaxoSmithKline letter. Important prescribing information regarding changes to the pregnancy subsection of the precautions section in the labels for Paxil and Paxil CR, December 2005. 9. Chambers CD, Johnson KA, Dick LM, Felix RJ, Jones KL. Birth outcomes in pregnant women taking fluoxetine. N Engl J Med 1996; 335: 10101015. Chun-Fai-Chan B, Koren G, Fayez I, et al. Pregnancy outcome of women exposed to bupropion during pregnancy: a prospective comparative study. J Obstet Gynecol 2005; 192: 932936. Yaris F, Kadioglu M, Kesim M, et al. Newer antidepressants in pregnancy: prospective outcome of a case series. Reprod Toxicol 2004; 19: 235238. Cohen LS, Altshuler LL, Harlow BL, et al. Relapse of major depres.
Hydrochlorothiazide is a thiazidic diuretic drug very frequently used in the treatment of high blood pressure and in edemas of cardiac, hepatic or renal origin. Several side effects have been described unrelated to its pharmacological activity, such as photosensitivity, skin exanthema and sexual dysfunction [1]. Most of these processes are not severe. The literature describes few side effects implying vital risk related to this diuretic drug; one of them is acute pulmonary edema. This entity, first described by Steinberg [2] in 1968, had been described in approximately 34 occasions by 1996 [3], and in 13 more cases up to now. We describe the case of a male who suffered two episodes of acute pulmonary edema after oral administration of 12.5 mg of hydrochlorothiazide.
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Sala, Sweden ; for 15 minutes room temperature, 1, OOOg ; . Immunofluorescence techniques were used for terminal deoxynucleotidyl transferase TdT ; and cytoplasmic and surface Ig M heavy chain staining, whereas an indirect immunoperoxidase staining technique on cytocentrifuge preparations was used for all other antibodie~.'~ A leukemia was considered to be a precursor-B common-ALL cALL ; if the malignant cells were positive for TdT, CDlO, CD19, andHLA-DRand negative for cytoplasmic and or surface Ig M heavy chain. Materials. Prednisolone sodium phosphate PRD ; , dexamethasone sodium phosphate DXM ; , daunorubicin hydrochloride DNR ; , l-asparaginase ASP ; , cytarabine ARA-C ; , vindesine sulphate VDS ; , vincristine sulphate VCR ; , mitozantrone hydrochloride MIT ; , teniposide TEN ; , and acidified 0.04 N HCl ; isopropanol were obtained from the hospital pharmacy. Thioguanine 6TG ; , mercaptopurine 6MP ; , and doxorubicin hydrochloride DOX ; were obtained from Sigma Chemical CO St Louis, MO ; . PRD was dissolved in saline. DNR, ASP, VDS, and DOX were dissolved in distilled water. 6MP and 6TG were dissolved in 0.1 N NaOH. DXM, ARA-C, VCR, MIT, and TEN were obtained in soluble form. Cells were cultured in suspension inRPM1 1640 GIBCO, Uxbridge, UK ; containing fetal calf serum Flow Laboratories, Irvine, UK ; and supplements as described previously.i6 MTT 3-[4, 5dimethyl-thiazol-2-yI]-2, 5-diphenyltetrazolium-bromide ; obwas tained from Sigma. Drug resistance assay. The MTT assay was performed at the research laboratory for pediatric hemato-onco-immunology ofthe.
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Foot ulcers are the most frequent cause of diabetes-related hospitalization. Diabetes is now the top cause of non-traumatic leg amputations in the developed world. Thus, diabetic foot ulcers and related infections result in long-term disabilities for patients with the condition and subsequent high demands on the healthcare system. Today's ageing population is also a key driver of the advanced wound management market as the elderly account for a significant portion of chronic wound-related cases. Overall, the global advanced wound care management market is about US to 7 billion with steady annual market growth of around 8.3%. In comparison to Regranex, WH-1 has similar wound healing efficacy, and being an extract of botanical material, has considerable prior human use experience. It is cost effective to manufacture less than US for a 15g tube ; and has a stable storage profile. In addition to accelerating tissue regeneration for wound closure, WH-1 also has antiseptic and anti-inflammatory properties. With these benefits, WH-1 can be considered a promising candidate for the treatment of diabetic-induced foot ulceration, burn healing and bed sore ulceration. Patent status and no. Worldwide patents of WH-1 have been filed: Taiwan No. 094145941 ; , United States 11 605, 178 , European Union 06024463.9; 07118802.3 ; , Japan 2007-211943 ; , South Korea 2007-0123636 ; , Malaysia PI-20072012 ; , India 1556 KOL 2007 ; , and China. Type of business relationship sought: Licensing or partnering. Licensing contact * Name: Liming Shen, Ph.D. * Position: Special Assistant to the President * Full address: 14F-1, No. 3 Yuan Qu St., Taipei, Taiwan * Telephone: 886 ; 2-2655-8558 x207 * Fax: * Email: 886 ; 2-2655-8559 limingshen microbio .tw.
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A Cochrane review of the efficacy of AZA and MP for inducing remission in active CD showed a benefit for thiopurine therapy compared with placebo with an odds ratio of 2.36 95% CI 1.57 to 3.53 ; , 65 see table 6.5. This equates to an NNT of five and a number needed to harm NNH ; of 14. Because of the delayed onset of action, the response rate was higher in the studies lasting more than 16 weeks NNT 4 ; . In attempt to accelerate the onset of action, a trial evaluating the efficacy of a high dose 36 hour infusion was no more effective than conventional oral dosing.66 Using the available data, mercaptopurine performs better NNT 3, 95% CI 2 to 8 ; than AZA NNT 6, 95% CI 3 to 16 ; although 95% confidence intervals overlap.67 and mesna.
CHA Health members enrolled in a smoking cessation program conducted by a trained facilitator can obtain nicotine replacement products for a copayment with a prescription and a voucher. Vouchers for nicotine patches are obtained through the smoking cessation counselor. Smoking cessation counselors can obtain vouchers by calling CHA Health Member Services at 859-232-8686 or 800-457-5683
The Top 25 drug products based on the total dollars spent for third quarter 2000, represented , 690, 519 in Indiana Medicaid payments to pharmacy providers. This amount is 12% higher than a year ago for third quarter 1999. Antipsychotic agents topped the list with , 627, 572 in paid Medicaid claims involving 7 drug products. Gastrointestinal agents followed with , 795, 961 in paid Medicaid claims for 3 drug products. A Gastrointestinal agent, Prilosec, was the number one drug product prescribed for third quarter 2000 with 18, 450 paid prescription claims to Medicaid members. Selective Serotonin Reuptake Inhibitors, COX-2 Inhibitors, and Anticonvulsants account for , 046, 419, , 811, 987, and , 491, 893 of the Top 25 totals and mesoridazine
GEMCITABINE injection 200mg, 1 gram MERCAPTOPURINE tablets 50mg METHOTREXATE oral solution 10mg 5ml; injection 25mg 1ml, 100mg PEMETREXEDinjection 500mg RALTITREXED injection 2mg TIOGUANINE tablets 40mg ETOPOSIDE capsules 50mg; infusion 20mg 1ml VINBLASTINE injection 10mg VINCRISTINE injection 1mg 1ml VINDESINE injection 5mg VINORELBINE capsules 20mg, 30mg; injection 10mg 1ml AMSACRINE infusion 75mg BORTEZOMIB injection 35mg CETUXIMAB infusion 2mg 1ml CRISANTASPASE injection 10 000 units DACARBAZINE injection 200mg TEMOZOLOMIDE capsules 5mg, 20mg, 100mg, ERLOTINIB tablets 100mg, 150mg HYDROXYCARBAMIDE capsules 500mg IMATINIB tablets 100mg, 400mg PENTOSTATIN injection 10mg CARBOPLATIN injection 10mg 1ml CISPLATIN injection 1mg 1ml OXALIPLATIN infusion 5mg 1ml PROCARBAZINE capsules 50mg DOCETAXEL infusion 40mg 1ml PACLITAXEL infusion 6mg 1ml IRINOTECAN infusion 20mg 1ml TOPOTECAN infusion 1mg 1ml TRASTUZUMAB injection 150mg TRETINOIN capsules 10mg 8.2 DRUGS AFFECTING THE IMMUNE RESPONSE AZATHIOPRINE tablets 25mg, 50mg MYCOPHENOLATE capsules 250mg; tablets 500mg CICLOSPORIN capsules Neoral ; 10mg, 25mg, 50mg, oral solution Neoral ; 500mg 5ml; infusion oily ; Sandimmun ; 50mg 1ml.
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MATERIALS AND METHODS Animals Female inbred Lewis rats Charles River, Sulzfeld, Germany; age range 6"8 wk; body weight 150"170 were housed in cages g ; under standard animal room conditions. One to 2 wk after arrival were allowed for acclimatization. At the time of scintigraphy, the rats weighed between 181 and 250 g. Induction of Antigen-Induced Arthritis Antigen-induced arthritis was induced as described previously 1 7 ; . Briefly, rats were immunized subcutaneously twice 2 1 and 14 days before ALA induction ; with a suspension of 1 ml methylated bovine serum albumin mBSA ; in phosphate-buffered saline PBS ; 500 tg mlmBSA in PBS; Sigma, Deisenhofen, Germany ; and 1 ml ofFreund's complete adjuvant FCA ; [2 mg mI Mycobacterium tuberculosis H37 Ra in Freund's incomplete adju vant FIA both from Difco, Augsburg, Germany]. On Day 0, a monoarticular arthritis was induced by intra-articular injection of 500 pg mBSA in 50 l into the right knee joint. The left knee PBS was injected with PBS only and served as reference for the measurement ofjoint swelling. Clinical Assessment of Arthritis The size of the knee joints was determined by measuring the medial-lateral diameter with a caliper before and at regular inter vals after induction of arthritis. Swelling was expressed as the difference in millimeters between the diameter of the arthritic right ; and that of the reference left ; knee. The increased uptake of 99mTc pertechnetate 99mTcO4 ; in ar thritic knee joints, an objective parameter to measure articular inflammation reference 22 in 12 ; , also was assessed. Briefly, 37 MBq 99mTcO4in 0.5 ml 0.9% NaCl were injected intraperitoneally under chloralhydrate-induced anesthesia 10 ml of 2.25% solu tion kg body weight, intraperitoneally 30"40mm thereafter, the joint uptake of the radioactive compound was determined using a gamma camera Basicam ; equipped with a high-resolution pinhole collimator both from Siemens, Erlangen, Germany ; . The levels of radioactivity contained in both knee joints were quantified by means of the regions of interest ROIs ; technique. The data were expressed as the ratio between radioactivity levels in the arthritic right ; and the reference knee joint left ; . Radiographic MRI Assessment of Joint Destruction and Cartilage Alterations The severity of joint damage, in other words the degree of destruction of cortical bone and the formation of osteophytes, was assessed radiographically. A reliable evaluation ofthe narrowing of the joint space, as a direct measure of cartilage damage, was impossible due to the small size of the joints and the availability of one-view images only. Therefore, to unequivocally analyze carti lage alterations, in a separate group of AlA rats n 4 ; , as well as in two normal animals, high-resolution MRI images were acquired on a BRUKER AMX 300 spectrometer field strength 7. 1 T ; equipped with a microimaging unit. Spin-echo techniques were used echo times 11 and 16 msec, and repetition times 500 and 1000 msec ; to image the excised rat knees ex vivo. A matrix of and metamucil.
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Oncology consultation with current status report, diagnostic imaging studies and copies of operative reports if history of surgery. Internal Medicine and or pulmonology consultation to include pulmonary function testing PFT ; with diffusion studies e.g., DLCO ; , thallium exercise stress test, 24-hour Holter monitor. CBC, liver function tests, serum electrolytes, ACE, ESR, transaminase, serum calcium and phosphorous, and 24-hour urinary calcium. PA and lateral chest x-ray within 6 months ; and a chest CT. A definitive histological diagnosis is required with waiver submission. This may be from a transbronchial lung biopsy or from skin, conjunctiva or salivary gland biopsy. Ophthalmology consultation including slit lamp examination is also required.
LUPRON 6-PK 15 LUPRON DEPOT INJ 15 LYRICA 33 levocarnitine metabolic modifiers ; 69 LYSODREN 15 levothyroxine sodium 61 M levoxyl 61 M-M-R II W DILUENT 1 DOSE 63 LEXAPRO 35 M-M-R II W DILUENT 10 DOS 63 LEXAPRO 36 M-R-VAX II 63 LEXIVA 10 MACRODANTIN 12 LEXXEL 28 MAGNESIUM SULFATE 44 lidocaine hcl cardiac ; 21 MALARONE 12 lidocaine hcl local anesth. ; 62 maprotiline hcl 36 lidocaine hcl mouth-throat ; 51 MARINOL 53 lidocaine hcl 65 MARPLAN 36 lidocaine-prilocaine 65 MATULANE 15 lidocaine 65 MAXAIR AUTOH AER 18 LIDODERM 65 MAXALT-MLT 41 LIMBITROL DS 36 MAXIDEX 50 LIMBITROL 36 MAXIPIME 3 LINCOCIN 7 mebendazole 2 LINDANE 65 meclizine hcl 52 LIPITOR 23 MEDROL 55 liposyn iii 46 medroxyprogesterone acetate LIPOSYN III 46 lisinopril & hydrochlorothiazide 29 contraceptive ; 61 medroxyprogesterone acetate 61 lisinopril 29 MEGACE ES 61 lisinopril 30 MEGACE ORAL 15 lithium carbonate 41 megestrol acetate 15 lithium citrate 41 MENACTRA 63 LITHOBID 41 MENEST 57 LITHOSTAT 43 MENOMUNE-A C Y W-135 63 LODOSYN 42 MENOSTAR 57 loperamide hcl 52 MENTAX 64 LOPROX 64 MEPRON 12 loratadine 1 mercaptopurine 15 LOTEMAX 50 MERREM 4 LOTREL 28 MERUVAX II W DILUENT 1 DO 63 LOTRISONE 64 MESNEX 69 LOTRONEX 54 MESTINON TIMESPAN 17 lovastatin 23 MESTINON 17 LOVAZA 23 metaproterenol sulfate 18 LOVENOX 20 metformin hcl 58 loxapine succinate 38 methazolamide 24 LOXITANE 38 methenamine hippurate 12 LUFYLLIN 66 METHERGINE 62 LUFYLLIN 67 methimazole 62 LUNESTA 41 METHITEST 56 LUPR DEP-PED INJ 15 and methadone.
Chemists analyze complex molecular structures and simulate how new drugs might interact with the human body.
In patients receiving Purlnethoi# mercaptopurine ; or lmuran4 azathioprine ; , the concomitant administration of mg of Zyloprim per day will require a reduction in dose to approximately one-third to one-fourth of the usual dose of mercaptopurine or azathioprine. Subsequent adjustment of doses of Purinethol or imuran should be made on the basis of therapeutic response and any toxic effects and methazolamide.
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Azathioprine is cleaved to mercaptopurine active and mercaptopurine.
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