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REFERENCES 1. Abraham, M. C., M. Desjardins, L. G. Filion, and G. E. Garber. 1996. Inducible immunity to Trichomonas vaginalis in a mouse model of vaginal infection. Infect. Immun. 64: 35713575. 2. Aburel, E., G. Zervos, V. Titea, and S. Pana. 1963. Immunological and therapeutic investigations in vaginal trichomoniasis. Rom. Med. Rev. 7: 13 19. Adugu, I. S., D. Nolder, D. S. Warhurst, and J. F. Rossignol. 2002. In vitro activity of nitazoxanide and related compounds against isolates of Giardia intestinalis, Entamoeba histolytica, and Trichomonas vaginalis. J. Antimicrob. Chemother. 49: 103111. 4. Ackers, J. P. 1990. Immunologic aspects of human trichomoniasis, p. 3652. In B. M. Honigberg ed. ; , Trichomonads parasitic in humans. SpringerVerlag, New York, N.Y. 5. Addis, M. A., P. Rappelli, A. M. P. de Andrade, F. M. Rita, M. M. Colombo, P. Cappuccinelli, and P. L. Fiori. 1999. Identification of Trichomonas vaginalis -actinin as the most common immunogen recognized by the sera of women exposed to the parasite. J. Infect. Dis. 180: 17271730. 6. Ahmed-Jushuf I., A. E. Murray, and J. McKeown. 1988. Managing trichomonal vaginitis refractory to conventional treatment with metronidazole. Genitourin. Med. 64: 2529. 7. Alcalde, E., L. Perez-Garcia, I. Dinares, G. H. Coombs, and J. Frigola. 1992. Synthesis and antitrichomonal activity of azinium azolium ; 4-nitrobenzimidazolate betaines and their derivatives. Eur. J. Med. Chem. 27: 171 176. Alderete, J. F. 1984. Enzyme linked immunosorbent assay for detecting antibody to Trichomonas vaginalis: use of whole cells and aqueous extract as antigen. Br. J. Vener. Dis. 60: 164170. 9. Alderete, J. F. 1988. Does lactobacillus vaccine for trichomoniasis, SolcoTrichovac, induce antibody reactive with Trichomonas vaginalis? Genitourin. Med. 64: 118123. 10. Alderete, J. F., and D. Provenzano. 1997. The vagina has reducing environment sufficient for activation of Trichomonas vaginalis cysteine proteinases. Genitourin. Med. 73: 291296. 11. Alper, M. M., B. N. Barwin, W. M. McLean, I. J. McGilveray, and S. Sved. 1985. Systemic absorption of metronidazole by the vaginal route. Obstet. Gynecol. 65: 781784. 12. Anorlu, R. I., A. F. Fagbenro-Beyioku, T. Fagorala, O. O. Abudu, and H. S. Galadanci. 2001. Prevalence of Trichomonas vaginalis in patients with vaginal discharge in Lagos, Nigeria. Niger. Postgrad. Med. J. 8: 183186.
Polymorphisms in genes encoding proteins that are neither direct targets of medications nor involved in their disposition have been shown to alter the response to treatment in certain situations Table 2 ; . For example, inherited differences in coagulation factors can predispose women taking oral contraceptives to deep-vein or cerebral-vein thrombosis, 80 whereas polymorphisms in the gene for the cholesterol ester transfer protein have been linked to the progression of atherosclerosis with pravastatin therapy.75 Genetic variation in cellular ion transporters can also have an indirect role in predisposing patients to toxic effects of drugs. For example, patients with variant alleles for sodium or potassium transporters may have substantial morbidity or mortality resulting from drug-induced long-QT syndrome. A mutation in KCNE2, the gene for an integral membrane subunit that assembles with HERG to form IKr potassium channels, was identified in a patient who had cardiac arrhythmia after receiving clarithromycin.76 Additional KCNE2 variants have been associated with the development of a very long QT interval after therapy with trimethoprimsulfamethoxazole, with sulfamethoxazole inhibiting potassium channels encoded by the KCNE2 8TA ; variant.77 Because KCNE2 variants occur in about 1.6 percent of the population and their effect on drug actions can cause death, they are excellent candidates for polygenic strategies to prevent serious drug-induced toxic effects.
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Et al., 1993 ; , and the single-channel current was estimated by fitting a linear regression to the varianceamplitude plots over different proportions of the time course of the averaged synaptic decay see Materials and Methods ; . Assuming a reversal potential of 0 mV, the estimated single-channel conductance of AMPARs obtained from OT neurons was significantly larger than that of VP neurons Fig. 4, Table 1 ; p 0.02.
Registry listing over 1, 300 artists working in western North Carolina. Each entry includes the artist's contact information, a picture of the artist's work, a list of the outlets where the work is available and a link to the artist's own Web site for those who have them. This electronic network offers three main advantages: 1 ; retailers can easily find the type of craft they seek for their store or gallery; 2 ; artists can connect with each other to collaborate on products e.g., a furniture maker seeks a ceramic tile artist ; or sell equipment; and 3 ; it serves as a bulletin board for news, events, and shows. While clearly not the face-to-face network that dominates the discussion here, this craft registry connects many disparate artists-entrepreneurs to each other and to potential markets, and offers those who are techno-phobic a business presence on the Internet.
Primarily due to lower U.S. NEUPOGEN demand, partially offset by favorable wholesaler inventory changes. The Company believes that U.S. NEUPOGEN demand declined at a mid-single digit rate from 2001. The decrease in U.S. demand was primarily impacted by the conversion of NEUPOGEN patients to NeulastaTM, partially offset by higher NEUPOGEN prices in the United States. The Company believes that, as demand for NeulastaTM increased subsequent to its U.S. launch, U.S. NEUPOGEN demand decreased at an accelerated rate due to the conversion of patients to NeulastaTM. In the fourth quarter of 2002, combined NeulastaTM and worldwide NEUPOGEN sales were 4.0 million, an increase of 53% over worldwide NEUPOGEN only sales in the prior year period. The Company believes this increase in combined sales was negatively impacted by a decline in U.S. NEUPOGEN demand in the low-20% range, driven by conversion of patients to NeulastaTM see "Financial Outlook--Trends expected to impact future operations" ; . Worldwide NEUPOGEN sales in 2001 were , 346.4 million, an increase of 2.7 million or 10% over the prior year. This increase was primarily due to worldwide demand growth, which includes the effect of higher prices in the United States. ENBREL The Company began recording ENBREL sales on July 16, 2002, subsequent to the close of the Immunex acquisition. For the period from July 16, 2002 through December 31, 2002, ENBREL sales were 2.1 million. In 2002, ENBREL sales were impacted by supply constraints. Corporate partner revenues Corporate partner revenues were 0.3 million in 2002, a decrease of .7 million or 21% over the prior year. Corporate partner revenues include 4.6 million related to amounts earned from Kirin-Amgen, Inc. "Kirin-Amgen" ; in 2002. The overall decrease in corporate partner revenues was primarily due to lower revenues earned from Kirin-Amgen, and to a lesser extent, lower revenues earned under other collaboration agreements. In 2001, corporate partner revenues were 2.0 million, an increase of .8 million or 2% over the prior year. Corporate partner revenues include 0.1 million related to amounts earned from Kirin-Amgen in 2001. The overall increase in corporate partner revenues was due to slightly higher revenues, primarily related to INFERGEN, substantially offset by lower amounts earned from Kirin-Amgen. Royalty income Substantially all royalty income earned by Amgen relates to amounts received from sales of Epoetin alfa by Johnson & Johnson in the United States for use in non-dialysis settings. Royalty income was 1.5 million in 2002, an increase of .8 million or 31% over the prior year. This increase was principally due to higher royalties earned from Johnson & Johnson relating to its sales of Epoetin alfa. In 2001, royalty income was 2.7 million, an increase of .7 million or 40% over the prior year. This increase was primarily due to higher royalties from Johnson & Johnson relating to its sales of Epoetin alfa. Cost of sales Cost of sales as a percentage of product sales was 14.7%, 12.6%, and 12.8% for 2002, 2001, and 2000, respectively. The increase in 2002 was principally due to the impact of higher manufacturing costs and royalty expense related to ENBREL compared to Amgen's other products. In addition, during 2002 the Company recorded the inventory acquired from Immunex at its estimated fair market value see Note 3, "Immunex acquisition" to the Consolidated Financial Statements ; . The increase in fair market value was recognized as cost of sales as the acquired inventory was sold. Cost of sales for 2002 reflects a charge of .7 million related to the 37.
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There is no marketable or feasible laser system for removal of cataracts. Cataracts must be removed through a surgical incision in the eye. They are broken into small pieces with high-frequency ultrasound and then removed with irrigation and suction. This is done through a micro-incision less than 3 millimeters in size. There is a cloudy membrane that may develop after cataract surgery which can be removed with a laser, which is probably the source of the confusion. Other lasers are used to treat eye conditions including Lasik, Diabetes, Macular Degeneration and Glaucoma.
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A comparative study of the subcutaneous inoculation of germfree and conventional guinea pigs with two strains of Trichomonas vaginalis. WALTERL. NEWTON, LUCYV. REARDON, ANDANNA M. DELEVA 56 and norethindrone.
Over the years, the world health assembly has adopted a number of resolutions drawing attention to the fact that most of the populations in various developing countries around the world depend on traditional medicine for primary health care, that the work force represented by practitioners of traditional medicine is a potentially important resource of the delivery of health care and the medicinal plants are of great importance to the health of individuals and communities [35].
The CDC recommends that the drug nitazoxanide be used for treatment of diarrhea caused by Crypto, but your healthcare provider can determine the best method of treatment. If you have diarrhea, remember to drink plenty of fluids to prevent dehydration. Rapid loss of fluids from diarrhea may be especially dangerous for babies. For more information on Crypto, please visit the Centers for Disease Control and Prevention s Web site or call the Health Department at 406258-3500 and norpramin.
Figure 3 a and b ; shows the timemortality curve of T. crassiceps cysts at different concentrations of nitazoxanide and tizoxanide. It can be seen that nitazoxanide and tizoxanide exhibited a cestocidal effect and the maximum effect was attained at 11 days of exposure. These results indicate that, like the benzimidazoles, the effect of nitazoxanide and tizoxanide was timeconcentrationdependent. Figure 3 c ; shows the mortality of T. crassiceps cysts after exposure to the tizoxanide plus albendazole sulphoxide combination as well as to tizoxanide and albendazole sulphoxide alone at the same concentrations used in the combination. It can be seen that the effect of each drug alone was slower than that observed with the combination. Thus after tizoxanide and albendazole sulphoxide treatments, the mortality became evident after 4 days of exposure, while after the combination the mortality was clearly evident after 2 days. Figure 4 shows the concentrationresponse curves of nitazoxanide, tizoxanide and albendazole sulphoxide. The EC50 values obtained for nitazoxanide, tizoxanide, albendazole sulphoxide and the tizoxanide and albendazole sulphoxide combination were 0.15, 0.12, 0.08 and 0.098 mg mL, respectively Table 1 ; . A t-test between nitazoxanide, tizoxanide and albendazole sulphoxide showed that there were no significant differences between EC50 values, which indicates that in vitro nitazoxanide and tizoxanide are equally potent as albendazole sulphoxide. The isobolographic analysis of the combination revealed that there were no significant differences between the experimental EC50Exp value 0.098 mg mL ; and the theoretical EC50Add value 0.103 mg mL ; P 0.05 ; , which indicates an additive interaction between both drugs.
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Photography spanning the time period from the 1940s to the 1990s was analyzed stereoscopically and combined with site data from other sources. The locations of soil and ground water samples indicating high levels of pesticides BHC, DDT, Toxaphene, and Dieldrin ; were registered to digital aerial images representing different dates of photographic coverage. As expected, some of the contamination correlated with the portion of the property associated with a former agricultural chemical formulation plant. However, the plant was only in operation for a short period of time and not all the contamination could be attributed to these former operations. Another portion of the property was utilized as a farm market for approximately 20 years. Primary operations at the farm market consisted of bulk storage of fertilizers that were distributed to local farmers. The farm market conceded that small quantities of pre-packaged pesticides were stored and sold at the facility; however, they contended that these operations did not contribute to those contaminants that drove the corrective action across the majority of the site. The historical photographic analysis revealed that the farm market used portions of the railroad property, which were not leased to them, to park tank trucks and tank trailers - equipment used to transport agricultural chemicals to local farms. In addition, the analysis revealed that the farm market leased equipment such as spreaders to local farmers, and that these spreaders were also parked on railroad property not leased by the farm market. The farmers could purchase chemicals from other sources and use the farm market's spreaders to dispense pesticides on their fields. Contaminants were found in high concentrations in areas where these spreaders were washed and parked. This source of contamination was only discovered through identification of the agricultural equipment and a washing area onsite using stereoscopic analysis of the historical photography. The preceding examples demonstrate the value of using historical aerial photography in conjunction with other site environmental data to document the timing of various contamination events. Historical Aerial Photography, Stereoscopic Analysis, Agricultural Chemical Facilities and norvir.
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The acid labile pharmaceutically active substance the acid labile compound ; in `230 Patent claim 6 is omeprazole, and the pH buffering alkaline reacting compound in `230 Patent claim 6 is magnesium hydroxide. Langer Tr. at 1201: 2-11. ; As and novantrone.
Cell Culture. All cell lines were maintained in a culture medium consisting of Dulbecco's modified Eagle's medium supplemented with 10% FBS, 100 units ml penicillin, and 100 g ml streptomycin. KX 3 4R2, KX 4 2R2, and KX 4 4R1 cells were further supplemented with 0.6 mg ml genetecin. K-177 cells were further supplemented with 0.6 mg ml genetecin and 90 g ml hygromycin-B. Cells were maintained in an atmosphere of 5% CO2 in a humidified incubator at 37C and were subcultured weekly at a subcultivation ratio of between 1: 20 and 1: 100. For assays, 96-well plates were coated by treatment with 50 l per well of a sterile solution of 50 g poly-D-lysine 3070 kDa ; for 1 h followed by aspiration and washing with 75 l of sterile water and allowing the plates to dry in a laminar flow hood. Cells were seeded into these plates at a subcultivation ratio of between 1: 2 and 1: 4 and grown to near confluence in 75 l culture medium. IMR-32 cells were seeded into 96-well plates precoated with collagen type I Becton Dickinson ; to improve cell attachment and reduce fibroblast populations 38 and nitazoxanide.
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| Nitazoxanide pharmacologyName: Phone: Relation to Myeloma: Patient Patient Family Member Patient Friend Nurse Clinician Address: City: State: Zip: Email: Order total: Necklace 0 each ; $ Bracelet 0 each ; $ Earrings 0 pair ; $ Large Pin 0 each ; $ SUBTOTAL $ Tax please add 6% sales tax to all orders within state of CT ; : $ GRAND TOTAL: $ Payment By Credit Card: Visa Mastercard Amex Card# Signature: Exp. Date Please make all checks payable to the Multiple Myeloma Research Foundation or MMRF. Please return to: MMRF, 51 Locust Avenue, Suite 201, New Canaan, CT 06840 Fax: 203-972-1259. For more information, call 203-972-1250 and novolog.
Agar. Long-term storage was performed in the vapour phase of liquid nitrogen by adding 5 % w\v ; of DMSO to the culture broth. The physiological properties of strain HKI 0122T are listed in Table 1!
Treatment with an NPWT pump and supplies is considered not medically necessary and, therefore, not covered when: Adequate wound healing has occurred. Any measurable degree of wound healing has failed to occur over the prior month. Cancer is present in the wound. The equipment or supplies are no longer being used for and nutropin
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Table 6.33: Response of Improvement performance for increase of competitiveness after ISO implementation Improvement level Frequency Percent % ; Cumulative Percent no. ; Excellent improvement 1 ; Satisfactory improvement 2 ; Slight improvement 3 ; No improvement 4 ; Total 6 12 4 % ; 25.0 75.0 91.7 and nuvaring.
Nitazoxanide did not adversely affect male or female fertility in the rat at 2400 mg kg day approximately 20 times the clinical adult dose adjusted for body surface area.
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