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Bristol-Myers Squibb Therapeutic focus OAD market share Marketed products R&D pipeline Muraglitazar Basulin Inhaled Insulin Pfizer Therapeutic focus Marketed products R&D pipeline Exubera Novartis Therapeutic focus Marketed products R&D pipeline LAF237 Merck KGaA Therapeutic focus Marketed products R&D pipeline Index List of Figures Figure 1.1: Prevalence of obese and overweight adults in US, 1976-2000 Figure 1.2: Proportion of type 2 diabetics diagnosed, 2003 Figure 1.3: Management of type 2 diabetes by physician type, 2003 Figure 1.4: Proportion of drug treated type 2 diabetics treated with insulin in monotherapy or combination, 2003 Figure 2.5: Development timeline for antidiabetic drug classes, 1920-2004 Figure 2.6: Overview of diagnosis rates, treatment rates and insulin prescribing trends in six major markets, 2003 Figure 2.7: Approved combination therapies for type 2 diabetes, 2003 Figure 2.8: Positive and negative developments influencing the antidiabetics market, 2004 & forwards Figure 2.9: Overview of the non-invasive insulin pipeline, 2004 Figure 3.10: Insulin brands by company and type, 2004 Figure 3.11: US European * market share of leading insulins % ; , 1999-2003 Figure 3.12: Humulin SWOT analysis Figure 3.13: NovoLin SWOT analysis Figure 3.14: Humalog SWOT analysis Figure 3.15: NovoLog SWOT analysis Figure 3.16: Apidra SWOT analysis Figure 3.17: Lantus SWOT analysis Figure 3.18: Levemir SWOT analysis Figure 4.19: Sales of OAD categories in Europe * and US $m ; , 2003 Figure 4.20: Global * market share of leading sulfonylureas % ; , 1999-2003 Figure 4.21: Amaryl SWOT analysis Figure 4.22: Glucotrol XL SWOT analysis Figure 4.23: Global * market share of leading biguanides, 1999-2003 Figure 4.24: Glucophage XR SWOT analysis Figure 4.25: Glucovance SWOT analysis Figure 4.26: US European * market share of leading TZDs % ; , 1999-2003 Figure 4.27: Actos SWOT analysis Figure 4.28: Avandia SWOT analysis Figure 4.29: Avandamet SWOT analysis Figure 4.30: US European * market share of leading AGIs % ; , 1999-2003.
There are three core components to the ARC: Administrative Core, Shared Core, and Pilot Core. Administrative Core The Administrative Core is under the direction of Dr. Carrie Randall, the Center Director. The Administrative Core is the hub of the ARC. It is the central coordinating point for all ARC activities. It influences each core and research component and is the glue that holds all the pieces together to make a cohesive, functioning unit. The Administrative Core offers the following provisions: 1 ; defined physical space; 2 ; unambiguous leadership; 3 ; a clear management and committee structure; 4 ; administrative and fiscal services; and, 5 ; a means for communication, integration, and quality control. Shared Core The Shared Core, directed by Dr. Suzanne Thomas, serves as a centralized, efficient approach to providing services needed by the ARC investigators who are conducting basic science and clinical alcohol research. The Shared Core encompasses the Intake Office, a centralized screening and recruitment service, contracts with specialized medical and pharmacy services, which are needed for clinical trials, and provides standardized training for both basic science and clinical research assistants. The Shared Core contains the Office of Statistics and Database Management, an expert statistical consulting service. Pilot Core Dr. Raymond Anton, the ARC's Scientific Director for Clinical Research, also directs the Pilot Core. The function of the Center's Pilot Core is to promote and identify new investigators and technologies to enhance our mission of finding improved treatments for alcoholism. The Pilot Core has established mechanisms for soliciting, reviewing, and monitoring pilot projects. The goal of this core is to bring in exciting new technology and investigators and to identify promising investigations that can augment the overall mission of the Center.
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The LCG has a longstanding collaboration with the EORTC Radiation Oncology Group, the UK Medical Research Council MRC ; and the Dutch Association of Pulmonary Physicians NVALT ; . Trial 08021 is conducted in collaboration with the Italian Lung Cancer Project ILCP ; . Further collaborations with the Eastern Cooperative Oncology Group ECOG ; and other European groups are under discussion.
To further study the developmental process of transplanted germ cells in the colonies, recipient seminiferous tubules were examined 3 mo after transplantation Table 2 ; . The average length of the colonies had increased to 3.4 mm. Even in very long colonies, the cell association in every part of a colony was qualitatively similar to that of the normal stage e.g., colony 10 in Table 2; Fig. 4 is comparable to A[IIII] in Fig. 1B ; . However, there were significant quantitative differences between cell numbers in transplanted colonies and normal seminiferous epithelium. The average rate of increase in the length of transplanted colonies was estimated to be approximately 1.1 mm mo, resulting in a mean length of 3.4 mm 3 mo after transplantation. Although this estimation is compatible with previous results [12], the rate of increase in colony length in the first.
RESULTS Body weight gain, food intake and organ relative weights. Obese Zucker rats gained progressively more weight than their lean littermates and were significantly heavier P 0.001 ; after wk 1 of treatment. In OP rats, weight gain was strongly diminished P 0.001 ; relative to OC rats throughout the experiment Fig. 1 ; . Weight gain also was less in LP rats compared with LC rats P 0.001 ; . Daily food intake throughout the study was greater in the obese Zucker rats than in their lean littermates fed the same diet P 0.001 ; Table 2 ; . Food intakes of the 2 groups of lean rats did not differ, but that of OP rats was lower than that of OC rats P 0.0295 ; . OC rats were characterized by increased P 0.001 ; liver relative weight, and reduced kidney and heart relative weights compared with LC rats Table 2 ; . OP rats had drastically reduced relative liver weight P 0.001 ; compared with OC rats, reaching values that did not differ from those of lean rats. The kidney relative weight was reduced P 0.05 ; , but heart relative weights did not differ compared with the OC rats. Organ relative weights of LP rats did not differ from those of LC rats, except for the relative renal weight, which was augmented P 0.05 ; . Systolic blood pressure. SBPs increased slowly in obese Zucker rats as they aged and were greater than in the lean rats after 4 mo of treatment P 0.0001 ; Fig. 2 ; . Maximal SBPs.
From its beginnings, the tip line experienced success. In the first month of operations, over 200 citizens called the number. Over the next few months, the number of calls escaladed. To increase the line's effectiveness, LMPD reached out to the corporate community and civic leaders to help. The response was overwhelming! A marketing campaign was developed by MBA students at a local university, quick tip crime reporting cards were developed and printed by the Texas Roadhouse Corporation, Insight Communications provided free public service announcements PSAs ; , and the local media agreed to font the crime tip line on the screen during crime stories appearing on the news. Perhaps the most significant impact of the marketing campaign was the innovative public service announcements. Instead of a one officer asking for assistance from citizens in stopping crime, local prominent citizens agreed to and nutropin.
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Special thanks to elliott vichinsky, md; keith quirolo, md; dru foote, pnp from children's hospital oakland and nuvaring.
After the emergency has passed, tell your doctor about your emergency within 24 hours or when it is medically reasonable to do so. If you cannot make the call, ask the hospital or someone acting for you to make the call. This will help your primary care physician arrange appropriate follow-up care.
Town these elements, the creation mount, the womb cave, the temple trees, were most clearly visible through just a turn of one's eyes to their direction. Later they made pillars, of stone or marble, in place of the trees, they made a sanctum in the church in place of the womb cave and they made a dome instead of the mount of creation , but with the Christian version of what God's love did for man and what example Christ gave to his followers , this conspicuous mountlike dome also reminded the sight on the equally conspicuous mount Golgotha. Of course, Miyiaki, all that to us and to all our contemporaries, since all saw it on the screen, and to all people from now on, since all will be hearing of it, will be connected with ground zero. OK, zero height is not conspicuous through being a mount but it is conspicuous and ever present in our memory, through having been so focused on and zoomed on by the cameras who were as shaken witnessing it as the human eyes witnessing it along. How horrible that this or any other age or place would resume the touch with those other orders of existence through witnessing the love between people who in couples kissed each other goodbye and grabbed each other's hand and jumped off to the sidewalk having so short a notice to prepare for such death, at least Christ chose his death himself and prepared longer before making the existence of love in all world's orders visible through such a conspicuous window on mount Golgotha ; yiaki reading all this was thinking that the only other time he had felt similarly with reading this letter and with leafing Mumford's "The City in History" which he had already started leafing parallel to the drummer's letter amazed of course at also the fantastic synchronicity between the reception of both but not bothering at all to explain it ; the only time that he had felt similarly about how primitive communities had a way to feel as existent the continuation of their touch with the reality that the community felt had given birth to its members, was once that he had read that a Pygmies' myth of creation saying that the world had been born out of the forest nearby their village since it was the forest that gave life to the village by providing both plants to eat and animals to hunt and in a discussion with the drummer they had some days after the excursionists' arrival, Miyiaki after telling the drummer about Mumford, also told him this story about the Pygmies and the drummer commented as follows: "So through what we would call superstition with our age's criteria, a Pygmy felt for his everyday visible reality the awe and the wonder and the respect and the enthusiasm and the uncanniness etc etc. in front of a mystery in the same way that in our age a physicist of the Wheeler type feels when thinking about the continuity between our usual physics and the physics which wonders about the pregeometry or about whatever is needed to speak not just about the creation of the world at the big bang but also about the creation of the laws of physics themselves, while a physicist who is not superstitious with his own criteria just wonders whether Wheeler got a little cuckoo in the head with growing age and became something of a superstitious Pygmy. I wonder what Feynman would say about all this". Miyiaki answered: "I don't know what Feynman would say about all this but I know what he would say about whether Wheeler went crazy with old age" "What?" "That he had been crazy all along already since young age, and also that when Wheeler says crazy things the other physicists should read his lips and not miss a word because from his own experience Feynman knew that a Wheelerian craziness always turned out a not at all crazy theory later, maybe by some other physicist. You want me to tell you where he said that or you believe me?" "No , no, I do remember when he said that and I would take your word anyway. You want to hear which of all Feynmanian lines I had said to Plucky he liked and said he saw then as good guides in life issues too and not just in physics?" "Oh yes! That I would love to hear" "He liked both lines plus the fact they looked as contradicting each other plus the fact that really being applied by one person at least, namely Feynman , it was proved they did not really contradict each other. One was his gag "To approach a new subject with an open mind doesn't mean to approach it with an empty mind" The other was his story going like "When I wanted to understand quantum electrodynamics I got the real book to read on the subject, Dirac's , and I opened it on the last page and it went like "Despite all our efforts the problem has not been solved, so I though to myself if the problem could be solved in this way then it would be more probable that Dirac and not me would solve it , so let me try to see and olmesartan.
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I'm not going to sit there and police it. That's not my job.I'm not going to follow and try to figure out what's going on. I don't have time for that. I don't find myself being the drug police.I have enough things I have to do. If I prescribe an adequate amount, and if someone loses it or whatever, then obviously I'll see them again and if they need more medication, I'll give it to them. If someone comes in and tells me that they're in pain, well I have to accept that they're in pain. Whether I believe them or not.I mean you get in trouble for it if you don't. --Three Physicians CASA Focus Group.
The NSW Government should be commended for finally agreeing to lower distance criteria for the Isolated Patients Transport and Accommodation Assistance Scheme IPTAAS ; . This will provide financial relief for many people in rural and regional NSW who are currently facing heavy transport and accommodation costs when they access health treatment, often with little or no assistance. But NSW Health should not rest on its laurels with this announcement. Despite the planned changes to IPTAAS, rural patients will continue to face significant barriers to accessing health services. IPTAAS recipients will still not be able to exercise any choice in relation to their health provider, and will still have to meet often hefty upfront costs before they can claim a subsidy. There is a chronic shortage of funds for non emergency health transport, with community transport operators across NSW over-run with requests for assistance in order to get to medical appointments. NSW Health has poorly managed its Transport for Health Program, with no formalised policy framework leading to the inappropriate use of funds for and omalizumab.
No. 01.02 Page -148. Library Services a. Request for authorization to reclassify six part-time positions to regular for the Aldine and Octavia Fields branch libraries, with hours for each not to exceed 31 hours per week and not less than 900 hours per year. b. Request for authorization for the director and an employee of the County Library to attend legislative day of the Texas Library Association February 6-8 in Austin at an approximate total cost of 2. c. Request for authorization for an employee of the County Library to travel to Denton January 29-30 to speak with perspective library science graduates of the University of North Texas at an approximate cost of 0. 9. Youth & Family Services a. Request by Juvenile Probation for authorization for six Burnett-Bayland Home residents and an employee to travel to Prairie View for a field trip February 3, with travel by county vehicle. b. Request by Juvenile Probation for changes to the payroll records of two employees. c. Request by Community & Juvenile Justice Education for authorization for an employee to attend a seminar of the Texas Society of Certified Public Accountants January 31 in Houston at a cost of 0. d. Request by Community & Juvenile Justice Education for authorization for four employees to attend the annual Texas Charter School Conference April 9 in Austin -10 at an approximate total cost of , 300. e. Request by Children's Protective Services for authorization for an employee to attend a meeting of the Southern Accreditation Commission February 22-23 in West Palm Beach, Fla., at no cost to the county. f. Request by CPS for authorization for the County Judge to execute an amendment to an agreement with the Texas Department of Protective and Regulatory Services to increase program funding for family services. g. Request by CPS for approval of a part-time truancy learning camp coordinator position for the TRIAD Prevention Program in connection with a Community Development grant. h. Request for authorization for an employee to attend a conference concerning drug abuse issues February 4-6 in Waco at an approximate cost of 0.
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F9999 Continued From page 73 is "Septic Shock as a direct consequence of the Sacral Decubitus". 2. The facility neglected to implement and follow the following policies for R2: a.The facility policy titled "Pressure Ulcer Prevention"states the following: "A standarized pressure ulcer risk assessment will be used to identify residents who are at risk for the development of pressure ulcers. This standardized assessment will be completed as follows: On admission, Weekly for the first four weeks after admission for each resident at risk; Quarterly; and Whenever clinically indicated." "An individual plan of prevention will be developed to meet the needs of the resident. It will include, but is not limited to: consideration of mechanical support surfaces, nutrition, hydration, repositioning, rehab restorative program to maintain or improve mobility activity status, skin condition and overall clinical condition." "Individualized interventions to prevent the development of pressure ulcers will be implemented as defined in the plan of care. Evaluation of the effectiveness of the individualized resident plan of care will include, but is not limited to: Daily and weekly skin assessments conducted by licensed staff; The assessment and valuation conducted weekly by the skin team." b. The facility policy titled " Pressure Ulcer Documentation" states the following: "A thorough assessment of wounds that develop and oms.
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Includes an increase to revenues of 5 million from the harmonization of Pfizer Warner-Lambert accounting methodology for Medicaid discounts and contract rebate accruals. 2 ; Reflects reclassification of certain marketing expenses as a result of adopting EITF Issue No. 00-25 and certain sales incentives as a result of adopting EITF Issue No. 00-14. Both reclassifications were from Selling, informational and administrative expenses to Revenues. 3 ; Includes costs of 6 million associated with the withdrawal of Rezulin, a loss on the sale of animal health's feed-additive products of million and a gain on the sale of Omnicef of million. 4 ; Includes a gain on the sale of the Rid line of lice-control products of million and novolog.
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