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1.5 pH units lower than those collected after citric acid candy stimulation mean, 4.3 0.8; range, 3.4 7.2; n 260 ; . The latter yielded lower pH values 1.7 pH units ; than did oral fluid collected with the neutral cotton swab mean pH, 6.0 0.6; range, 4.27.2; n 130.
Type I neuraminidase deficiency ; can be detected by this HPLC system. Neuraminic acid and sialyllactose, for example, are eluted with gradient 11 2 ; , and other and more-sialylated oligosaccharides can be chromatographed with a comparable system 26 ; . Validation The HPLC procedure described with PCD and PAD detection systems 2 ; seems to be suitable for recognizing Pompe disease, a-mannosidosis, G1-gangliosidosis, G-gangliosidosis, and 3-mannosidosis from urinary HPLC patterns. The characteristic peaks seen in these diseases were not detectable in a series of 40 urines from individuals without lysosomal diseases, so there were no false positive results. The tetraglucoside peak, one of the peaks seen in Pompe disease, is a normal urinary compound but is clearly increased in urine from patients with Pompe disease, even the late-onset form. No complex sample preparation is required, and automatization is easy. PAD detection gives a good resolution and separation of characteristic oligosaccharide peaks but is less specific than PCD. PAD patterns from undesalted urmnes are complex and sometimes difficult to interpret. Like Hommes and Varghese 3 ; , we found that the retention times of the various urinary compounds are very stable, whereas the peak areas vary with metabolite concentration Table 2 ; . High peaks in urines from young children interfere with detection and quantification of other oligosaccharide peaks. Therefore, we used a combination of PCD with undesalted urines ; and PAD with desalted urines ; to recognize abnormal oligosaccharide peaks. The CVs for peak areas were calculated from the percentages of total peak area, to correct for differences in injection volume. For accurate quantification of the oligosaccharides, an internal standard must be added. Correlation was good between HPLC and TLC patterns, for Pornpe disease, a- and 3-mannosidosis, and GM1- and.
TABLE IV Effects of epinephrine, serotonin, and adrenergic serotonergic antagonists in vitro on rat skeletal muscle or glycogen content and phosphorylase a activity Epitrochlaris preparations were incubated in the presence of epinephrine, serotonin, propranolol, oxprenolol, methysergide, or cyproheptadine either added alone or in combination as indicated below and as described under "Materials and Methods." After 1 h of incubation, phosphorylase a activity was determined in homogenates of these muscles as described under "Materials and Methods." Values shown are the means f S.E. for at least 10 experiments.
Playford et al 2000 ; , Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders. American Journal Clinical Nutrition 72, 514.
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Multidrug resistance inhibitors P-glycoprotein is a cellular membrane protein enFigure 2. Current cooperative group phase III studies of coded by the MDR1 gene, which serves as an gemtuzumab ozogamicin GO ; in acute myeloid leukemia AML ; . efflux pump to extrude chemotherapy from the cell. It is particularly expressed in older adults ized study in which gemtuzumab ozogamicin is added to and in those with relapsed and refractory AML and is assoconventional cytarabine and daunorubicin. Patients then ciated with multidrug resistance.3 Inhibition or blockade undergo a second randomization to receive or not receive of this efflux pump is an appealing therapeutic strategy. gemtuzumab ozogamicin as maintenance. The Medical Several agents inhibit P-glycoprotein in vitro, but with the Research Council MRC ; is also testing the addition of exception of a SWOG trial testing cyclosporine given with gemtuzumab ozogamicin to a conventional 3-drug induc- cytarabine and infusional daunorubicin in relapsed and tion regimen in a randomized study. Patients in this trial refractory patients, randomized trials of MDR modulators are also randomized to receive or not receive gemtuzumab such as cyclosporine and PSC-833 in both previously treated ozogamicin in consolidation. The European Organization and untreated patients with AML have not shown benefit for Research and Treatment of Cancer EORTC ; is currently and, in some, have demonstrated excessive toxicity Table randomizing older adults to induction chemotherapy with 5 ; . More potent second generation modulators such as or without gemtuzumab ozogamicin and then randomiz- Zosuquidar formerly LY335979 ; are currently being studing patients again in consolidation with chemotherapy. The ied.20 This agent does not require reduced doses of conEastern Cooperative Oncology Group ECOG ; is conduct- comitant chemotherapy, a potential limitation of other ing a trial in which patients in CR after 2 cycles of inten- multidrug resistance inhibitors such as PSC-833. The ECOG sive consolidation chemotherapy are randomized to a singe recently completed a prospective randomized trial of condose 6 mg m2 ; of gemtuzumab ozogamicin prior to au- ventional induction with cytarabine and daunorubicin with tologous HSCT. The Dutch-Belgian Hemato-Oncology Co- or without Zosuquidar. Patients in this trial were also ranoperative Group HOVON ; is testing the benefits of domized to receive or not receive the drug combined with gemtuzumab ozogamicin as maintenance. If randomized chemotherapy in consolidation and gemzar
In 2005 Hupac dispatched on average 82 trains per day, with a total of 519, 160 consignments by rail + 15.9% ; . Traffic in the main business, Shuttle Net UCT ; , increased by 17.2% and reached a volume of 495, 659 consignments. Of that, 374, 993 + 13, 3% ; went through the Alps, 120, 666 + 31, 2% ; went on nontransalpine stretches, primarily from harbours in the West into the European heartland. The only decline was in the Rolling Highway service through the Gotthard tunnel which recorded a drop of 6.6% with 23, 501 loaded trucks. The current year, 2006, is showing strong growth in transalpine traffic, not least thanks to the additional handling capacity at the expanded terminal at Busto Arsizio-Gallarate. Hupac's main market strength is transalpine intermodal traffic through Switzerland. This is strongly influenced by Switzerland's transport policy, whose objective is to shift freight traffic from road to rail. Two out of every 3 tons of transalpine traffic are sent through Switzerland by rail. In Austria and France the situation is the reverse rail is continuing to lose market share to road traffic. In recent years, the strong growth in road traffic has slowed to a stop. In 2005, the number of lorries in Alpine transit fell by 4% to 1, 204, 000. In contrast, intermodal traffic volumes have been growing strongly for years. Its share of transalpine traffic exceeds that of truck loads and pure road traffic. The transport policy target of reducing road consignments to 650, 000 truckloads is not likely to be achieved by the originally set point in time, and it will be possible only if financial support of the modal shift policy will continue.
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1 . Annual Scientific Meeting of the Australasian College of Dermatologists, Perth 2005 . Sinclair R, Chapman A, Magee J Age-Related Changes In Scalp Hair Follicle Number Presentations at National International Meeting 1 . Annual Scientific Meeting of the Australasian College of Dermatologists, Perth 1992. Subcutaneous Inclusion Dermoid Cyst of the Scalp. 1. Annual Meeting of the Australian Dermatopathology Society, Sydney 1992. Anatomy of the Nail. 1. Annual Meeting of the British Society for Investigative Dermatology, Sheffield, September 1992. The Basement Membrane Zone of the Nail. 1. IVth Congress of the European Society for Paediatric Dermatologists, Bournemouth 1993 Congenital Cysts of the Scalp. 1. Third Congress of the European Academy of Dermatology and Venereology, Copenhagen 1993. Cryosurgery Workshop. General Principles of Treatment of Premalignant And Malignant Lesions. 1. European Hair Research Society IV annual Meeting in Stockholm, October 1993. Weathering of Hair in Congenital and Hereditary Hair Dystrophies and genotropin.
This booklet was started long before the London Underground bombings, Hurricanes Katrina and Rita hit the Gulf Coast, or the threat of a pandemic outbreak. What those three events impressed upon us though, was the importance of being calm and prepared for some of the unexpected or unanticipated twists and turns life sometimes surprises us with. People are much less likely to panic in a crisis and thus prevail in a bad situation if they have a plan and have their family prepared ahead of time so that everyone knows what they need to do. The Foundation for NC Future is a private organization that addresses issues important to our State's future primarily improving the efficiency and fiscal accountability of North Carolina's state government and improving North Carolina's health care system. Increasingly, it is becoming obvious that emergency preparedness is a key issue that will affect North Carolina's future and impact our state's economy and its citizens. The North Carolina Division of Emergency Management assists our citizens in responding to hurricanes, terrorist threats and other crises. This booklet is intended to assist in that effort. The Foundation for NC Future is pleased to offer this booklet as a "beginner's handbook" for dealing with sudden, unwelcome changes in our day-to-day lives. It is by means a comprehensive guide with answers to any and all emergencies. It is, however, a good place to start. There are several websites listed at the end of the booklet that would also be great places to go for further information on the topics we are discussing as well as other related issues. An informed and prepared public can and will reduce the serious impact any city or state incurs when there is an emergency. Having as many people as possible able to sustain themselves for several days will allow the emergency personnel to direct their efforts to those in the most critical need of help. If you remember the chaos we all saw in the aftermath of Hurricane Katrina, you can appreciate the need to be prepared even more. As a precaution, we want to remind you that we are not recommending any particular product or service and that you should never begin taking medicine without fully discussing the use with your doctor. Preparation has a way of allaying fear of the unknown. The one comment that has been emphasized by everyone threatened by nature or man-made terror is to not give into the scare tactics and to lead our lives as normally as we always have. To that end, we hope this information helps. N.C. Senator Robert Pittenger.
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Hans and PC - thanks so much for these valuable and very complete examinations about the role of potassium. I have an observation to share which fits right in. Ever since the cardioversion after ablation, I have had more PVCs I'm told ; than I ever had previously. After a particularly stressful day and without proper meals, I noted after the evening meal which was proper and innocent of any possible triggers ; , that PVCs were active and then I had a run of about 20 quick beats. This settled into a pattern of a big thump every 30 beats. This was unusual and a bit unsettling and not wanting it to continue to become a new "milestone" for me. I took 1 4 tsp. potassium chloride in warm water along with some magnesium. probably about 600 mg. Probably, I didn't need the magnesium, but I wasn't taking any chances. Within less than 5 minutes after swallowing the potassium water, my irregular beat normalized and has been absent ever since! So. just one more testimonial that for whatever reason, potassium deficiency is definitely a contributor.and most likely THE most important consideration. I now have a little sealed, waterproof vial of KCl powder that I'll carry around with me as my emergency stash in case this crops up again. It is possible that my ectopy might not have become anything more than just that, but I wasn't taking any chances. PC - I think that you should be inventing this potassium meter now that you are retired. I'll place my order now. Great idea. Thanks again for this very substantial and supportive evidence in making the case for potassium deficiency. Best and gentamicin.
Appendix I. Collection details of all specimens referred to in tables and figures by their herbarium accession number, or in the case of PCA diagrams, by locality. Within land districts, records are ordered by herbarium accession number. G. amabilis OTAGO: Old Woman Range, A. P. Druce, Mar 1986, CHR 395767; Garvies, D. Glenny 6383, Feb 1996, CHR 509909; Old Man Range, D. Glenny 6406, Feb 1996, CHR 509931B; Old Man Range, P. N. Johnson 1375, Feb 1997, CHR 511803; Cardrona, M. Rixon, P. Thomas, V. Tregidda, M. F. Watson, Feb 1998, CHR 523435; Lammermoor Range, C. Jensen, Mar 1997, CHR 526407; Rastus Burn, D. Glenny 6862, Feb 1997, CHR 559424; Old Man Range, D. Glenny 6887, Mar 1997, CHR 559448. G. androsacea ECUADOR: Cordillera de las Lagunitas, P. M. Jorgensen et al. 832, MO 4664864. G. angustifolia NELSON: Mt Olive, A. P. Druce, Mar 1983, CHR 393808; "Turks Cap Range", A. P. Druce, Feb 1989, CHR 395647 holotype ; , isotypes CHR 395645 and 395646; Hoary Head, A. P. Druce, Feb 1986, CHR 395841; Lookout Range, A. P. Druce 1888, Feb 1993, CHR 476152; Mt Patriarch, D. Glenny 7748, Feb 1999, CHR 525241; Mt Arthur, D. Glenny 6834, Feb 1997, CHR 530508; Granity Pass, D. Glenny 7365, Feb 1998, CHR 559991; Mt Owen, Sentinel Hill, D. Glenny 7367b, Feb 1998, CHR 559994; Poverty Basin, D. Glenny 7372, Feb 1998, CHR 559999; Garibaldi Ridge, D. Glenny 7418, Mar 1998, CHR 560049; Mt Arthur, D. Glenny 7440, Mar 1998, CHR 560068. G. antarctica CAMPBELL ISLAND: D. R. Given 9364, Dec 1975, CHR 24689, 284793; Azimuth Hill, C. Meurk, Dec 1995, CHR 510016; E. J. Godley, Jan 1969, CHR 549026 spirit collection. G. antipoda ANTIPODES ISLAND: G. Taylor, Nov 1995, CHR 510015; "bog 1", E. J. Godley, Feb 1969, CHR 549027 spirit collection.
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R. Caraballo, R. A. Bologna, J. Lukban, and K. E. Whitmore Graduate Hospital, Philadelphia, Pennsylvania, USA; Northeastern Ohio University, Akron, Ohio, USA; and Cooper Hospital University Medical Center, Camden, New Jersey, USA Patients with pelvic floor dysfunction often have multisystem complaints, including a combination of overactive bladder, interstitial cystitis IC ; , voiding dysfunction, chronic pelvic pain, vulvodynia, overactive bowel, and or constipation. The purpose of this study was to evaluate our experience in the use of neuromodulation with unilateral sacral foramen electrode Interstim, Medtronics Corporation, Minneapolis, MN ; in patients with predominantly bladder-related symptoms and other pelvic floor disorders. A total of 17 patients 15 women and 2 men ; , average of 60.6 years range, 38 to 81 ; , had a permanent S3 electrode implanted from June 1998 to December 1999 with a follow-up of 3 to 22 months mean 13.4 months ; . The primary endpoint was patient perception: 0%, no improvement, failure; 25% improvement, mild failure; 50% improvement, moderate; 75% improvement, significant; 75%, cured. Voiding diary results and programming events were also reviewed. Sixteen patients 94% ; considered the procedure a success and would do it gain. Of the 15 patients with refractory urge incontinence, 3 20% ; were failures, 11 73% ; were markedly improved, and 1 6.7% ; was cured. All 17 patients had urgency, frequency, and pain IC ; : 3 18% ; were failures and 14 82% ; had marked improvement. Voiding diaries showed a decrease of 30% frequency on voiding diaries. Of the 10 patients 59% ; who had pelvic pain, 3 30% ; had no or minimal improvement, 5 50% ; had marked improvement, and 2 20% ; were cured. The 2 patients 12% ; with fecal incontinence reported no improvement. Constipation was present in 5 patients 29% ; : 1 had no improvement, and 4 had marked improvement. Diarrhea was present in 3 18% ; : 1 had 50% improvement and 2 had marked improvement. The mean number of reprogramming events per patient was 9.3 range, 2 to 22 ; . The highest mean for reprogramming was for those patients with pelvic pain at 15.8. The mean amplitude per patient was 3.1 V range, 0.7 to 7.2 V ; . Complications included mild resolved cellulitis in 3 patients 18% ; , resolved wound dehisUROLOGY 57 Supplement 6A ; , June 2001 and gentian.
EPA 1993 ; and others e.g., Dourson and Stara, 1983; Beck et al., 1994 ; describe a method for establishing toxicity factors RfDs ; for non-carcinogenic compounds by applying "uncertainty factors" to the highest dose level found to be without observable adverse effects the No.
Classification of single neurons A total of 560 CA1 neurons were recorded and separated from the trace- and pseudoconditioned animals, however, 429 neurons were recorded on the days of early and asymptotic conditioning reported in this study. The cluster plots of spike waveform measurements used to separate single neurons changed each day in most cases, and only 7 of the 429 neurons were tracked across multiple days of training. The 429 neurons were separated into pyramidal cells and theta cells as described in the METHODS . Using these criteria and ginger.
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Such claim, Lessor, upon notice from Lessee, shall resist and defend such action or proceeding. 34. ARTICLE HEADINGS: The article headings in this Lease and position of its provisions are intended for convenience only and shall not be taken into consideration in any construction or interpretation of this Lease or any of its provisions. 35. APPLICABILITY TO HEIRS AND ASSIGNS: The provisions of this Lease shall apply to, bind and inure to the benefit of Lessor and Lessee, and their respective heirs, successors, legal representatives and assigns. It is understood that the term "Lessor" as used in this Lease means only the owner, a mortgagee in possession or a term lessee of the Building, so that in the event of any sale of the Building or of any lease thereof, or if a mortgagee shall take possession of the Premises, the Lessor herein shall be and hereby is entirely freed and relieved of all covenants and obligations of Lessor hereunder accruing thereafter, and it shall be deemed without further agreement that the purchaser, the term lessee of the Building, or the mortgagee in possession has assumed and agreed to carry out any and all covenants and obligations of Lessor hereunder. 36. OUTSIDE PARKING SPACES: Lessee's occupancy of the Premises shall include the use of the number of outside parking spaces as set forth in the Preamble. Lessor shall not be responsible for any damage or theft of any vehicle in the parking area and shall not be required to keep parking spaces clear of unauthorized vehicles or to otherwise supervise the use of the parking area. Lessee shall, upon request, promptly furnish to Lessor the license numbers of the cars operated by Lessee and its subtenants, licensees, invitees, concessionaires, officers and employees. If any vehicle of the Lessee, or of any subtenant, licensee, concessionaire, or of their respective officers, agents or employees, is parked in any part of the Common Facilities other than the employee parking area s ; designated therefor by Lessor, Lessee shall pay to Lessor such reasonable penalty as may be fixed by Lessor from time to time. All amounts due under the provisions of this Article 36 shall be deemed to be Additional Rent. 37. LESSOR'S LIABILITY FOR LOSS OF PROPERTY: Lessor shall not be liable for any loss of property from any cause whatsoever, including but not limited to theft or burglary from the Premises, and any such loss arising from the negligence of Lessor, its agents, servants or invitees, or from defects, errors or omissions in the construction or design of the Premises and or the Building, including the structural and non-structural portions thereof, and Lessee covenants and agrees to make no claim for any such loss at any time. 38. PARTIAL INVALIDITY: If any of the provisions of this Lease, or the application thereof to any person or circumstances, shall to any extent, be invalid or unenforceable, the remainder of this Lease, or the application of such provision or provisions to persons or circumstances other than those as to whom or which it is held invalid or unenforceable, shall not be affected thereby, and every provision of this Lease shall be valid and enforceable to the fullest extent permitted by law. 39. LESSEE'S BROKER: Lessee represents and warrants to Lessor that its broker, as defined in the Preamble is the sole broker with whom Lessee has negotiated in bringing about this Lease and Lessee agrees to indemnify and hold Lessor and its mortgagee s ; harmless from any and all claims of other 22.
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Patients with bilirubin higher than 2 mg dl were not eligible to receive gemtuzumab ozogamicin in clinical trials; therefore, caution should be exercised when administering this agent to patients with hepatic dysfunction and ginkgo
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Myelodysplasia is associated with a stem cell phenotype. British Journal of Haematology 1991; 78: 28-34. ; . te Boekhorst PA, de Leeuw K, Schoester M, Wittebol S, Nooter K, Lowenberg B, Sonneveld P. Predominance of functional multidrug resistance MDR-1 ; phenotype in CD34 + acute myeloid leukemia cells. Blood 1993; 82 10 ; : 3157-3162. 50 ; . Paietta E, Andersen J, Racevskis J, Gallagher R, Bennett J, Yunis J, Wiernik PH. Significantly lower P-glycoprotein expression in acute promyelocytic leukemia than in other types of acute myeloid leukemia: immunological, molecular and functional analyses. Leukemia 1994; 8: 968-973. ; . List AF. Multidrug resistance: clinical relevance in acute leukemia. [Review]. Oncology 1993; 7 10 ; : 23-32. 52 ; . Nooter K, Sonneveld P, Oostrum R, Herweijer H, Hagenbeek T, Valerio D. Overexpression of the mdr 1 gene in blast cells from patients with acute myelocytic leukemia is associated with decreased anthracycline accumulation that can be restored by cyclosporin-A. International Journal of Cancer 1990; 45: 263-268. ; . Guerci A, Merlin JL, Missoun N, Feldman L, et al. Predictive value for treatment outcome for acute myeloid leukemia of cellular daunorubicin accumulation and P-glycoprotein expression simultaneously determined by flow cytometry. Blood 1995; 8: 2147-2153 . 54 ; . Linenberger ML, Hong T, Flowers D, Sievers EL, et al. Multidrug-resistance phenotype and clinical responses to gemtuzumab ozogamicin. Blood 2001; 98 4 ; : 988-94. 55 ; . Bailly J-D, Muller C, Jaffrezou J-P, Demur C, Cassar G, Bordier C, Laurent G. Lack of correlation between expression and function of P-glycoprotein in acute myeloid leukemia cell lines. Leukemia 1995; 9: 799-807. ; . Musto P, Melillo L, Lombardi G, Matera R, di Giorgio G, Carotenuto M. High risk of early resistant relapse for leukaemic patients with presence of multidrug resistance associated P-glycoprotein positive cells in complete remission. Br J Haematol 1991; 77: 50-53. ; . Van den Heuvel-Eibrink MM, Wiemer EA, de Boevere MJ, van der Holt B, et al. MDR1-gene related clonal selection and P-glycoprotein function and expression in relapsed or refractory acute myeloid leukemia. Blood 2001; 97: 3605-3611. ; . van den Heuvel-Eibrink MM, Wiemer EA, Prins A, Meijerink JP et al. Increased expression of the breast cancer resistance protein BCRP ; in relapsed or refractory acute myeloid leukemia AML ; . Leukemia 2002; 16 5 ; : 833-839. 59 ; . van der Kolk DM, Vellenga E, Scheffer GL, Muller M, et al. Expression and activity of breast cancer resistance protein BCRP ; in de novo and relapsed acute myeloid leukemia. Blood 2002; 99 10 ; : 3763-3770. 60 ; . van der Kolk DM, de Vries EG, Noordhoek L, et al. Activity with expression of the multidrug resistance protein P-glycoprotein, MRP1, MRP2, MRP3, and MRP5 in de novo and relapsed acute myeloid leukemia. Leukemia 2001; 15 10 ; : 1544-1553 and ginseng.
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