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Article 31 - 40 of 150 for bioavailability ordered by relevance alphabet entacapone entacapone inn ; ipa : ; is a catechol-o-methyl transferase inhibitor for the treatment of parkinson's disease.
Colon cancer lines with three cycles of the combination of BCNU plus O 6-BG, the two MMR deficient cell lines became resistant and that resistance was also caused by mutations in the AGT protein. The MMR proficient cell line maintained sensitivity to the drug combination and expressed wild-type AGT protein. In contrast, we observed mutations in AGT in the MMR proficient Daoy and TE671 ; as well as MMR deficient D341 MED and D283 MED ; cell lines summarized in Table 2 ; . This difference probably reflects the fact that, in our experiments, the AGT was characterized after selection for resistance to the drug combination. Because D341 MED and D283 MED have MMR deficiencies, their corresponding OBR sublines were selected more rapidly than the MMR proficient cells.
It is unknown whether any benefit accrues from the early administration of entacapone in an attempt to limit the total daily dose of sinemet, and such a course is not recommended at this a typical antipsychotic drugs such as clozapine, quetiapine seroquel ; , olanzapine, or risperidone are sometimes required to control psychotic symptoms that may be induced by levodopa or dopamine agonists see table 1.
Assessments were done after 2 weeks on L-dopa plus entacapone 200 mg t.i.d. q.i.d. plus either selegiline 10 mg or placebo o.d. LD, L-dopa; E, entacapone; S, selegiline; AUC0-6h, area under the plasma concentration-time curve over 6 hours, Tmax, time to peak plasma concentration; Cmax, peak plasma concentration. N 12 for each group. No significant differences between treatments and entecavir.
See May 21, 1998, declaration of Ronald Markman, 1-3, and 35 [701-703], attached as Exhibit 81 emphasis added ; . By submitting Dr. Markman's declaration, the State was on notice that involuntary drugging of inmates with powerful tranquilizers at the county jail was a routine practice and was obliged under Brady principles to provide any and all information concerning these practices. The alleged loss or destruction of Mr. Williams' 1979-1981, jail medical psychiatric medication records is highly suspect and is a bad fath failure to preserve evidence that allowed the prosecutor to unfairly manipulate the trial. See infra.
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Stowe RL, Ives NJ, Counsell C, Clarke CE, Gray R, Wheatley K. MAOBI therapy in early Parkinson's disease: a systematic review of randomised controlled trials. Movement Disorders 2004; 19; 9 Abstract P530 ; . Wheatley K, Clarke CE, Ives NJ, Gray R. Cabergoline vs. Levodopa Monotherapy. Movement Disorders 2004; 19: 733-734; Wheatley K, Ives N, Gray R, Clarke C. Role of entacapone in later Parkinson's disease not yet established. Journal of Neurology Neurosurgery & Psychiatry 2004; 75; 7. Hancock B, Ives N, Gore M. Adjuvant interferon therapy for melanoma. Journal of Clinical Oncology 2005; 23; 10. Macleod AD, Counsell CE, Ives N, Stowe R. Monoamine oxidase B inhibitors for early Parkinson's disease Review ; . The Cochrane Library 2005: 1-38; 3. Wheatley K, Ives N, Lee S, Eggermont A, Kirkwood J, Hancock B, Gore M, Suciu S. Interferon-alpha as adjuvant therapy for melanoma: a meta-analysis of the randomised trials. 6th World Congress on Melanoma 2005 Abstract SSS-1.
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Comparison of the catalytic efficiencies of different enzymes or of the utilization of different substrates by the same enzyme. The relative kcat and relative kcat Km values for 1-hydroxypyrene, 4nitrophenol, scopoletin, 4-methylumbelliferone, and entacapone with eight UGT1A isoforms are and epirubicin.
Pharmaceuticals in the WHO regional office for Europe, based in Copenhagen. He holds Master's degrees in pharmacy and business administration. Previously he worked for ten years with WHO in Latin America. Among others, one of his particular interests and work is on public policy on pharmaceutical pricing and reimbursement of medicines in Europe. Dr Angelika Kiewel 1952 ; Germany. Economics, Social Policy, Public Health. Lecturer and Author. Head of Pharmaceutical Care Policy Unit at the Bundesverband der Innungskrankenkassen Bergisch Gladbach. Accountable for negotiations with associations of physicians, pharmacists and pharmaceutical industrie. Member of the Federal Committee of Physicians and Health Insurance Funds. Member of the AIM Pharmaceutical Expert Group Brussels. Walter Kbele 1948 ; Germany. Master of Business Administration, President of Pfizer Deutschland GmbH and Pharmacia. Working in the Pharmaceutical Business for Pfizer Germany since 1983 and Member of the Executive Board since 1994. Delegate of BadenWrttemberg of the German Association of Research-Based Pharmaceutical Companies VfA. Dr Vladimir Kozyreff 1943 ; Belgium. Medical doctor, clinical biology and nuclear medicine in vitro. Worked in research in molecular biology. Formerly Associate Medical Director in the Central and Eastern Europe region for the American pharmaceutical firm, Pfizer. Now works at the European Commission EuropeAid, A3, `Private sector and economical reforms' ; , particularly in questions of social and economical cohesion and public health matters for the Tacis and CARDS regions. Mag. Hans Kratzer 1965 ; Austria. Lawyer, Master of Law, University of Vienna, Director External Affairs, MSD Austria; Head of Strategic Planning Postal Operator 19982002 ; , Advisor to the Government 199598 ; , Experience in the Telecoms Sector 198795 Publications and Lectureships: Commentary on the Austrian Telecoms Law, Course of Studies on Integrated Communication Danube University ; . Barbara Kutryba MA 1959 ; Poland. QA Process Engineer Organization of Healthcare Systems; Senior Adviser at the Accreditation Centre in National Centre for Quality Assessment in Healthcare NCQA Honorary Secretary of the Board of the Polish Society for Quality Promotion in Healthcare SQPH Board Member of the European Society for Quality in Healthcare ESQH ; . Dr Jukka Lassila 1951 ; Finland. Economics. Research Director at the Research Institute of the Finnish Economy ETLA ; in Helsinki; Scientific coordinator in the EU 5th Framework research project Demographic Uncertainty and the Sustainability of Social Welfare Systems DEMWEL ; . Ming-Liang Lee, Taiwan. Commander-in-Chief, the Taiwan SARS Task Force. Dr Gnther Leiner MD 1939 ; Austria. An internal specialist, medical superintendent at the Institute of Rheumatology, Rehabilitation and Psychosomatic Medicine at Bad Gastein, formerly Member of the Austrian Parliament and speaker of the conservative party in the Health Committee. President of the International Forum Gastein. Magdalena Letowska, Poland. Director, National Center of Transfusion Medicine and Adviser to the Minister of Health, Poland.
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10.1 Pharmaceutical products should only be sold and or distributed to persons or entities who are entitled to acquire such products as demonstrated by the applicable national, regional and international legislation. Written proof of such authority must be obtained prior to the dispatch of products to such persons or entities. 10.2 The supplier of pharmaceutical products should, prior to the dispatch of such products, ensure that the person or entity, e.g. the contract acceptor for transportation of the pharmaceutical products, is aware of and complies with the appropriate storage and transport conditions. 10.3 The dispatch and transportation of pharmaceutical products should be commenced only after the receipt of a valid delivery order or material replenishment plan which should be documented. 10.4 Written procedures for the dispatch of pharmaceutical products should be established. Such procedures should take into account the nature of the product, as well as any special precautions to be observed. 10.5 Records for the dispatch of pharmaceutical products should be prepared and should include at least the following information: -- date of dispatch; -- name and address of the entity responsible for the transportation; -- name, address and status of the addressee e.g. retail pharmacy, hospital, community clinic -- a description of the products including, e.g. name, dosage form and strength if applicable and eplerenone.
An absence attack is characterized by abrupt cessation of ongoing activity, a vacant stare, and a period of unresponsiveness lasting from a few seconds to half a minute. The absence may be accompanied by brief clonic movements, especially of the eyelids, a reduction in tone causing the body to slump, or automatic movements. Absence seizures occur more commonly during childhood. The absence must be distinguished from the complex partial seizure, which it may resemble. Absence status is not uncommon in childhood and may be mistaken for inattention. Myoclonic seizures These are brief shock-like contractions of groups of muscles.
8.2.1. Signs of uncoupling in vivo 8.2.1.1. Body temperature I, II, IV ; Entacapone had no effect on body temperature even at a dose of 600 mg kg day. By contrast, after each dose of tolcapone 300 mg kg day ; body temperature increased within one or two hours from dosing about one centigrade, the highest increase being 1.1C p 0.01 ; Figure 9 ; . DNP 20 mg kg day also induced a significant increase in rectal body temperature compared with controls 1.3C, p 0.001 ; . The increased temperatures decreased to basal level within 24 hours. A more marked rise in body temperature up to 41C preceded the deaths of six rats treated with tolcapone 600 mg kg day Figure 10 ; . The combination of carbidopa and levodopa did not induce any and epogen.
Int.Cl.7 A61B6 00; A61B6 02. Imaging chain with miniaturized C-arm assembly for mobile X-ray imaging system. OEC MEDICAL SYSTEMS, INC.
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But a decade ago, when California mandated a major change in its gasoline blends, the switch increased the hold of big oil companies over the market, raised costs to consumers and boosted refinery profit margins. The state's air board and ethanol enthusiasts hope the new change will push California's gas prices down. Using more additives will help stretch gasoline supplies in a state that consumes more fuel than it can produce, they say. But the change will force the state's 14 gasoline refineries to retool their equipment, possibly at great expense. Those costs could trickle down to drivers. One fuel expert with the California Energy Commission estimated that the move could raise gasoline prices by 4.2 cents to 6.5 cents per gallon. That would add up to 6 million to .1 billion per year. "It's kind of a double-edged sword, " said Susanne Garfield, spokeswoman for the energy commission, referring to the offsetting effects of increased supply and higher refiner costs. The California Air Resources Board approved the change Thursday. The vote marked a significant step in Schwarzenegger's "low-carbon fuels" initiative, an effort to cut carbon dioxide emissions from the state's vast fleet of cars. In a prepared statement, Schwarzenegger hailed the decision as "an important step toward diversifying California's fuel supply with alternative and, in this instance, renewable fuels." Oil industry representatives say refineries can make the changes, but not as fast as the state wants. Refineries that can't meet the 2010 deadline can get a two-year extension from the air resource board, but only if they find other ways to cut carbon dioxide emissions. One possibility is buying old, inefficient cars from vehicle fleets and junking them. "If it's the state's goal to increase ethanol in gasoline, we don't have an argument with that, " said Cathy Reheis-Boyd, chief operating officer with the Western States Petroleum Association. "You know in California what it takes to get permits, buy new equipment and install it? Two years is not enough." In the 1990s, the state ordered refineries to begin producing a new, unique gasoline formula designed to fight smog. Smaller refineries closed down rather than pay for the needed upgrades. The state ended up with a gasoline blend used nowhere else and made by a limited number of refineries and companies. Most energy economists point to that as one of the main reasons California has the nation's second-highest gasoline prices; only Hawaii's are higher. In 2003 and 2004, California stopped blending MTBE methyl tertiary-butyl ether ; into its gasoline. The toxic chemical helped gas burn more thoroughly, but it also polluted groundwater. In its place, the state started adding ethanol. The amount of ethanol used in each gallon, however, wasn't as large as the amount of MTBE it replaced. MTBE had made up 11 percent of every gallon of gas sold in the state. But state officials worried that using more than 6 percent ethanol would make air pollution worse, not better. They even fought with the federal government, arguing that California shouldn't have to use ethanol at all and epoprostenol.
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Figure 1. DNA fragmentation, caspase-3like activity, and caspase-9like activity in sensitive and resistant cell lines treated with CdA. All cells were treated in the absence or presence of 100 nM or 1 CdA. A ; DNA fragmentation. Cells were incubated in the presence or absence of drug for 48 hours. Subsequent propidium iodide staining and FACS analysis as described in "Materials and methods" ; was conducted to quantitate the number of cells with subdiploid amounts of DNA. This subdiploid population was indicative of cells with fragmented DNA and is depicted graphically. Open bars depict cells treated with diluent alone, gray bars represent cells treated with 100 nM CdA, and black bars show cells treated with 1 M CdA. B ; Caspase-3like activity. Cells were incubated in the presence or absence of CdA for 12 hours. DEVDase activity was measured using a commercially available labeled peptide, DEVD-AMC. Cleavage of this fluorescently labeled peptide and consequent release of free AMC, which was measurable with the use of a spectrofluorimeter, indicated the presence of caspase-3like proteases in cell extracts. Color designation of bars is identical to that for panel A. C ; Caspase-9like activity. Cells were incubated in the presence or absence of CdA for 12 hours. LEHDase activity was quantitated using the caspase-9 substrate, LEHD-AMC. Cleavage of this fluorescently labeled peptide and consequent release of free AMC, which was measurable with the use of a spectrofluorimeter, indicated the presence of caspase-9like proteases in cell extracts. Results shown for panels A-C are representative of 4 separate experiments and eprosartan.
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