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In the majority of industrialised countries, fruits and vegetables provide an estimated 2-3 mg day of pro-vitamin A carotenoids, of which -carotene is the principal component Granado et al, 1996 ; . An approximate -carotene intake of 1.8 mg day in a randomly selected population of women in the USA has been reported Chug-Ahuja et al, 1993 ; , the main dietary sources being carrots, orange juice, oranges, tomatoes and dark green leafy vegetables. The average intake in the German National Food Consumption Survey was 1.81 mg day Pelz et al, 1998 ; , mainly from carrots. An average -carotene intake of 1.7-2.1 mg day has been reported in Finland Heinonen, 1991 ; , and of 3.0 mg day in The Netherlands Goldbohm et al, 1998 ; . Levels of fruit and vegetable consumption, however, vary greatly between individuals and -carotene intake may be much higher than average in people who regularly consume substantial amounts of foods such as carrots Gregory et al, 1990; Scott et al, 1996 ; . Some authors have reported that -carotene intake varies according to seasonal factors, perhaps due to the differing availability of specific fruits and vegetables, or because of factors such as light and heat that may affect the carotenoid content of foods Olmedilla et al, 1994; Rautalahti et al, 1993; Takagi et al, 1990 ; . The SCF has not recommended the consumption of -carotene and carotenoids in general, beyond what is needed to supply vitamin A SCF, 1993. Patient home professional home newsletters feedback survey main menu home conference coverage professional education cme cancer news disease centers physician resources about us oncology stocks - 71 - 9% ; 0 0% ; 0 0% ; - 48% ; cancer news : article ellence and cmf superior to cmf alone for adjuvant therapy of early breast cancer british researchers associated with the national epirubicin adjuvant trial neat ; have reported that ellence epirubicin ; plus cmf cyclphosphamide, methotrexate and fluorouracil ; is superior to cmf alone for adjuvant therapy of women with early breast cancer. 2 active obt drugs % 400 c ml % 50 %dc due ae %r5 to d mix 66 28 23 Tumor lysis syndrome epirubicin may induce hyperuricemia.
Schutt P, Ebeling P, Buttkereit U, et al. Eur J Haematol, 2005 January; 74 1 ; : 40-6. : highwire anford cgi medline pmid; 15613105 The authors evaluated the efficacy and side effects of thalidomide 400 mg d ; in combination with vincristine, epirubicin and oral dexamethasone VED ; . Thirty-one patients were enrolled, 12 patients were exclusively treated with thalidomide in combination with VED and 19 patients received high-dose melphalan, for consolidation. The results showed CR in 19%, PR in 61%, stable disease in 16%, and progressive disease in one patient 3.2.

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Cl. 3 0784975 1956 ; CP-Pharma Handelsgesellschaft mbH of Germany Cl. 30 0785002 1956 ; Lidl Stiftung & Co. KG of Germany Cl. 1 0785108 1956 ; Merck KGaA of Germany Cl. 3, 5 0785109 ; The Trelivings Company Pty Ltd of Australia Cl. 1, 5 0785126 ; Bayer Aktiengesellschaft of Germany Cl. 1, 5 0785127 ; Bayer Aktiengesellschaft of Germany Cl. 1, 2, 6 ; ITW Construction Products ApS of Denmark Cl. 3 0785324 1956 ; Beiersdorf AG of Germany Cl. 1 0785394 1956 ; Stern-Enzym GmbH of Germany Cl. 5 0785413 1956 ; F. Hoffmann-La Roche AG of Switzerland Cl. 14 0785423 1956 ; CASA DAMIANI S.P.A. of Italy Cl. 40 0785431 1956 ; SHELL INTERNATIONAL PETROLEUM COMPANY LIMITED of United Kingdom Cl. 3 0785434 1956 ; Beiersdorf AG of Germany Cl. 33 0785443 1956 ; CASTELLO DELLE REGINE SPA of Italy Cl. 35 0780105 1955 ; EP FIRST LIMITED of United Kingdom and epogen.

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Economics and culture, a contribution measured, for instance, by the unprecedented number of Jewish Nobel Prize laureates. The Jewish theatre must continue to be part of this tradition of continuously demanding progress. It must therefore be a laboratory for radical thinking. It must be a laboratory for subversive oppositionist ideas. It must cast doubt upon every establishment, every regime, and every idea. It must protest against every injustice and support all those whose rights are infringed. It must be both farseeing and deep-seeing. Without bias. Without shame. Out of an aspiration to decode human nature, out of an aspiration to bring about a true Tikun Olam. And indeed, not by chance this conference is entitled "Tikun Olam" A World Reform - and not "Tikun Ha'am Hayehudi" which means the reform of the Jewish People. This choice expresses a trend embedded in our collective subconscious as Jews, and reflects our desire to be part of a global stream that encompasses the whole world as our field of activity. As I have contended earlier, the global stream will only be of value side by side with the particularist stream. For two thousand years our particular culture was mainly religious, and only at the end of the 19th century, with the inception of Zionism, was it joined by clear nationalist elements. It was in the wake of the Holocaust and the establishment of the State of Israel that these nationalist elements became the main thrust of our particular culture. It is still unclear whether, as many predict, the globalization process will actually weaken nationalism in the world. If it does, then the centrality of the State of Israel in Jewish culture will become weakened, and Jewish culture will have to define a particular identity for itself that is not based on nationalism, and apparently not on religion either. On what, then, will our future particular identity focus? I hope that the focus will be on the same aspiration towards progress, depth, and universal justice on the same "Tikun Olam", whose importance was sensed by the organizers of this conference, and who chose it as the title of their vision and erbitux.

Huhtamaki van Leer Ltd. Stralfors AB PROMAT INTERNATIONAL N.V. SIEMENS AKTIENGESELLSCHAFT, A joint stock company organised and existing under the laws of Germany and erlotinib. ArQule, a US-based biotechnology company engaged in the research and development of next-generation, small molecule cancer drugs, has granted Japanese company Kyowa Hakko Kogyo an exclusive licence to develop and commercialise ARQ 197 in Japan and parts of Asia Deal no. 27099 ; . Under the terms of the agreement, ArQule will receive US3 M in upfront and potential development milestone payments, including a US M cash upfront licensing fee. In addition, the agreement includes undisclosed sales milestone payments and double-digit royalties on net sales of ARQ 197. Kyowa will be responsible for clinical development costs and commercialisation of the compound in Japan, China, Hong Kong, South Korea and Taiwan. ARQ 197 is the lead product from ArQule's Cancer Survival Protein modulation programme. This small molecule mediates its effects by inhibiting the activity of c-Met, a receptor tyrosine kinase that plays multiple key roles in human cancer, including cancer cell growth, survival, angiogenesis, invasion and metastasis. Preclinical findings have demonstrated that ARQ 197 inhibits c-Met in a wide range of human tumour cell lines, and possesses antitumour activity against several types of xenografted human tumours in mice. Phase I data demonstrated clinical tolerability, pharmacokinetics and signs of antitumour activity in cancer patients with a broad range of metastatic solid tumour types who had failed earlier treatment regimens. ArQule's portfolio consists of two other clinical stage compounds ARQ 501 and ARQ 171. These E2F1 pathway activators result from an alliance with F. Hoffmann-La Roche, entered into in April 2004 Deal no. 16176 ; . Under the terms of this agreement, Roche obtained an option to license drugs resulting from ArQule's E2F programme in the field of cancer therapy. ARQ 197 adds to Kyowa's strong portfolio of anticancer drugs, which include mitomycin, 5-fluorouracil 5-FU ; , Leunase Escherischia coli L-asparaginase ; , Adriacin doxorubicin ; , Hysron H-200 medroxyprogesterone acetate ; , dacarbazine, Farmorubicin epirubicin ; , Platosin cisplatin ; and Navelbine vinorelbine ; . This oncology franchise positions the company strongly in Asian markets, and will allow it to develop and commercialise ARQ 197 effectively.

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