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Abused or assaulted by these individuals. The defendant contended that the incident began as horseplay, but was taken overboard. The defendant's psychiatrist acknowledged that the plaintiff clearly suffered emotional stress at the hands of his assailants. However, this expert testified that the plaintiff had many preexisting causes to his psychiatric condition including other background issues. The defendant's psychiatrist opined that within a few months, the plaintiff had recovered to the psychological state that he was at prior to the attack. The jury found that the defendant was not responsible for the assault. The case is currently on appeal. REFERENCE Plaintiff's psychiatrist: Carla Rogers from Philadelphia. Plaintiff's neuropsychologist: Andrea J. Casher from Philadelphia. Plaintiff's economist: David Bunin from Philadelphia. Defendant's psychiatrist: Robert Toborowski from Philadelphia. Jefferies vs. PEP Boys, Manny, Moe & Jack, Inc. Case no. 04-07- 1916; Judge Nina Quinones Alejandro, 10-31-05. Attorney for plaintiff: Kenneth M. Rothweiler of Eisenberg, Rothweiler, Schliefer, Weinstein & Winkler in Philadelphia. Attorney for defendant: Michael L. Banks of Morgan, Lewis & Bockius in Philadelphia. COMMENTARY: This bizarre case, which was both sensational and horrifying, was difficult from a defense standpoint. The Philadelphia jury hearing the case, no doubt experienced both compassion for the plaintiff and anger at the callousness of his attackers. The case was especially sympathetic in that the young plaintiff, currently 22 years old, has dealt with physical and emotional disabilities since childhood. He spent eleven years in special education classes, but was finally mainstreamed in high school. This incident, which seems to have pushed him over the edge of a psychological abyss, occurred the week before his senior prom. He thereafter required in-patient care. The defendant did not dispute that the incident occurred, although it contended that there were some discrepancies in the plaintiff's version of events. Rather, the defense maintained that it had no knowledge of the plaintiff's abuse and was not responsible for the actions of the misguided perpetrators. The plaintiff's chances for a successful verdict were linked to establishment that the incident resulted from a lack of supervision on the part of the defendant. The assailants were all males in their late teens to early 20s. They were, essentially, judgment proof and were not defendants in the case. Plaintiff's counsel may also have been concerned that if the individuals had been named as defendants, it may have caused a diversion of attention from the main allegations of negligent supervision. The testimony of the plaintiff was at direct odds with that of the defendant's store managers. The plaintiff claimed that the managers were well aware of his mistreatment and had even stood by and witnessed the abuse. The defendant's witnesses denied any knowledge that the plaintiff was anything but well-liked by his co-workers. To support its position, plaintiff's counsel stressed that even after this totally unacceptable assault upon the plaintiff, the individuals involved were not terminated nor disciplined in any way by the defendant. They were charged criminally and pled guilty to reduced assault charges. By the time of trial, the assailants had all left the defendant's employ for reasons other than the attack upon the plaintiff and none of them testified. Defense counsel strove to present the defendant in the most favorable light, arguing that it attempted to assist this young man with physical and emotional difficulties by giving him a job and had no indication that he would be attacked at work. The jury apparently accepted the defense position that it was not responsible for the mistreatment encountered by the plaintiff.
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1. Alcoholics qualitatively are different than others 2. Lose control, abnormal, influenced by biologic factors 3. Affects only part of our population 4. Encourages care and the medical community to be involved with treatment 5. Supports the belief that ONLY A SUBSET of the total population are vulnerable to harmful effects Only a fragment of the population has disease about 4% ; and public in general is unconcerned with how much or how often they drink Public policy approach: Society will be less likely to embrace broad preventive measures designed to create an environment less conducive to misuse and harm, alcohol tax increases, restrictions on availability, and anti-drunk driving measures.
By the most carefully selected remedy. The various phosphates, lactophosphates or glycerophosphates I believe not only sustain the vital force but contribute in some of these cases to the cure of the disease. I especially partial to some of the tissue remedies of Schussler. I believe there are cases in which they can be correctly adjusted and will prove curative. As the cases are advanced, serious blood changes must be anticipated, and diabetic coma must be guarded against as the most dangerous sequel. This condition results from blood changes, among which oxybutyric acid being found in the blood. Oxygen-carrying remedies, vegetable alteratives and hypodermoclysis with the normal salt solution must be regularly and persistently employed until the urine becomes plainly alkaline in reaction. A Dr. Hopkins, from Burlington, Iowa, claims to have cured three deeply seated cases by the use of the following prescription: Nitrate of uranium, 1 to 2 drams; fluid extract of jambul seeds, 1 to 3 drams; glycerin, 2 ounces; water, q. s. to 4 ounces. One teaspoonful four times a day and emtricitabine.
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Companies have used innovative methods to skirt this issue: a recent instance was the agreement under which Schering Plough paid Upsher-Smith USmn and ESI over USmn to refrain from launching generic versions of K-Dur potassium chloride supplement ; . The FTC filed a suit alleging anti-trust violation, but this was disallowed as the agreements between the parties allowed Upsher-Smith and ESI to launch a generic a few years before patent expiry and the Court held that Schering's suit was strong enough to delay entry anyway.
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Immature and unreliable clinical data to promote the off-label uses of its drugs Eloxatin and Elitek to physicians, Sanofi caused a particular Medicare carrier to authorize Medicare coverage for off-label use of the drugs. As a result, Sanofi knowingly caused false or fraudulent claims for payment or approval to be presented to an officer or employee of the government. Plaintiff further alleged that Sanofi encouraged the actions of its officers and employees to further these fraudulent practices and that, as a result, the government reimbursed physicians for treatments that it otherwise would not have had Sanofi and its employees not presented false or misleading information to the physicians in an effort to promote these drugs' off-label uses. Sanofi moved to dismiss for failure to plead facts that would establish the necessary elements of a claim under the FCA, and for failure to allege fraud with the required particularity under FRCP 9 ; b ; . The court found that plaintiff failed to satisfy FRCP 12 b ; 6 ; requirements because under no circumstances could he prove facts to support his claim that Sanofi violated the FCA by promoting offlabel uses of the drug to physicians. Therefore, plaintiff also failed to satisfy FRCP 9 b ; 's requirements because he did not sufficiently "plead the materiality requirement of the FCA in regard to Sanofi's alleged promotion of and causing doctors to prescribe Eloxatin" during the time period at issue, the court concluded. The court also held that plaintiff's allegations with respect to the drug Elitek failed to satisfy FRCP 9 b ; 's particularity requirements. Because plaintiff failed to allege that doctors to whom he promoted off-label use of Elitek actually submitted false claims to the government for the off-label uses of the drug, he did not allege facts that would entitle him to relief under the FCA, the court concluded. In doing so, the court also denied plaintiff's request for leave to amend his complaint. United States ex rel. Hess v. Sanofi-Synthelabo Inc., No. 4: 05CV570MLM E.D. Mo. Apr. 21, 2006 ; . This case reiterates the importance for a qui tam action brought under the FCA to meet the FRCP 9 b ; particularity requirement. B. Anti-Kickback Issues--OIG Advisory Opinions OIG Says Lab's Proposal to Pay Physicians for Blood Draws Could Be Subject to Administrative Sanctions The OIG concluded that a laboratory's proposal to provide free blood collection supplies to physicians and pay them for collecting blood samples implicates the Anti-Kickback Statute and could result in the imposition of administrative sanctions. Under the proposal, the laboratory would give the physicians blood drawing supplies at no charge and pay them roughly to per patient for collecting specimens. The lab would still submit claims for these blood draws and tests to patients' insurers, which include federal healthcare programs and enbrel.
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There is an article which is in one of the documents here, there were a series of articles on child delinquency in industrial schools. If I could draw your attention to page 22 of the book of documents. I afraid I don't know the newspaper nor who the special correspondent is. THE CHAIRPERSON: Q. MR. McGOVERN: It looks like The Irish Times and enfuvirtide.
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Brown-headed cowbirds significantly impact many southwestern willow flycatcher populations by decreasing or eliminating flycatcher productivity, nesting success, and juvenile survival Unitt 1987, Brown 1988, Whitfield 1990, USFWS 1993, Sogge 1995a and b, Whitfield and Strong 1995, Sferra et al. 1997, Sogge et al. in press ; . It is important to document if cowbirds occur at a flycatcher breeding site to determine if those flycatchers are at risk from cowbird brood parasitism. As noted earlier, another reason to watch for cowbirds is to avoid attracting cowbirds to a flycatcher territory or making flycatcher nests more detectable to cowbirds. Surveyors should look and listen for cowbirds at, and in the vicinity of, the survey site. This requires that surveyors are able to identify cowbirds by sight and vocalizations. The latter is particularly important because cowbirds are often heard even when not seen in the dense habitat at flycatcher sites. Accurate estimation of cowbird numbers at a site is often difficult. Cowbirds may be either very inconspicuous or very prominent. They often travel in groups, with individuals and groups ranging over wide areas during short periods of time. A count may be high or low depending on the activities of a cow and eloxatin.
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| Eloxatin more for_health_professionalsLack of policies, unfamiliar dosage forms and human error. DTCs can reduce such errors by monitoring, analysing, reporting errors and implementing corrective action see section 5.1 ; . 1.3.9 Information dissemination and transparency The DTC must disseminate information about its activities, decisions and recommendations to the staff who must implement the DTC's decisions. This may seem obvious, but it is often forgotten. Inadequate dissemination of information leads to a loss of credibility. It is also very important that the DTC operates in such a way as to ensure transparency of all its decisions and to avoid conflict of interest. In particular, members should either have no relationship with pharmaceutical companies or declare it openly so that conflicts of interest can be avoided. The only acceptable contact with pharmaceutical companies is to ensure the flow of information about their drug products in a way that is as unbiased as possible see sections 2.1 and 7.4.2 and enoxaparin.
The February, May, August, and November issues pages 727-728 of the August 1993 issue ; . Brief reports and reports of unusual cases should not exceed 1, 200 words and cannot have more than one table or figure or more than ten references; no abstract is required. Letters are welcomed and should not exceed 500 words. Material must be typed double-spaced on 8# -by-ilinch paper, with margins a minimum of 1 # inches on all sides. All pages should be numbered, and a word count of the text should be inchuded on the title page. Only pnincipal researchers or writers should be listed as authors. To expedite editing, authors will be encouraged to submit the final version ofthe paper on an IBM-cornpatible disk. The disk will be requested after the initial review stage, when the author is asked to submit a revised version of the paper or when the paper is accepted for publication. For more information, contact the editorial office at the number above.
The Planning Committee was made up of Basil M. Rifkind, Chair; Susan Clark, Michael J. Bernstein and Larry Blaser, representing the Office of Medical Applications of Research; Charles Glueck, Cincinnati General Hospital; William Hazzard, Johns Hopkins Medical School; Kenneth Lippel, Program Coordinator of the Atherogenesis Branch of NHLBI; Albert Oberman, University of Alabama Medical Center and entacapone.
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A procedure has been developed for purification of gic receptors may interact with, or a t least influence the the porcine brain a2-adrenergic receptor to homoge- activity of, two effector systems, i.e. adenylate cyclase and neity. a2-Adrenergic receptors were solubilized from Na + H exchange. Definitive exploration of this hypothesis porcine brain particulate preparations using sequen- necessarily will include reconstitution of the purified receptor tial extraction into sodium cholate- and digitonin-con-with putative effector components. taining The goal of the present studies was to develop methods for digitonin extract were identified using the a2-adrener- large-scale purification of the a2-adrenergic receptor from an gic selective antagonist, [SH]yohimbine, anddemoninexpensive, readily available tissue source. Because of the strated the same specificity for interactionwith adre- low density of a2-adrenergicreceptors in target tissues, affinnergic ligands did the receptors in particulate prep- chromatography, a technique exploiting the specificity of as ity arations. Extractioninto digitonin-containing buffers ligand-receptor interactions, is employed. This report deeliminated the modulation of receptor-agonist interactions by guanine nucleotides, but not by monovalent scribed the synthesis of a yohimbine-agarose affinity matrix that is easily prepared from relatively inexpensive, commercations. A novel affinity resin, yohimbine-agarose, was syn- cially available starting materials. Using this affinity matrix, thesized and used for purification of a2-adrenergic we have been able to purify the porcine brain cortex azreceptors. Using two sequential yohimbine-agarose af- adrenergic receptor to apparent homogeneity using two sefinity chromatography steps, digitonin-solubilized a2- quential yohimbine-agarose affinity chromatography steps. adrenergic receptors from porcine brain cortexwere MATERIALS AND METHODS AND RESULTS' purified to homogeneity assessed by radioiodination as and silver stain analysis of these preparations on soChromatography of the Digitonin-solubilized Porcine Brain dium dodecyl sulfate-polyacrylamide gel electropho- Cortex cYz-AdrenergicReceptor on Yohimbine-Agarose-Fig.lA resis. The purified a2-adrenergicreceptor has an ap- depicts the washing and elution of digitonin-solubilized porproximate M. 65, 000, as determined by photolabel- cine brain a2-adrenergic receptors from the yohimbine-againg of the adrenergic ligand-binding subunit. The yorose matrix. One attractive feature of the yohimbine-agarose himbine-agarose affinity resin shouldbeusefulfor purifying quantities of receptor sufficient for studies resin is its high capacity for adsorption of digitonin-solubilized az-adrenergicreceptors. Thus, theresin removed at least of receptor structure and function. 75% of the a2-adrenergicreceptors from digitonin-solubilized preparations applied at a ratio of approximately 50-60 ml of detergent-solubilized preparation of 1 ml packed yohima-Adrenergic receptors of the a2-subtype mediate diverse bine-agarose resin. The specificity of the adsorption properphysiological effects. This receptor population evokes secre- ties of the resin was implied by the ability of the a2-adrenergic tion of dense granules from the human platelet, but blocks antagonist phentolamine 10 p M ; block a2-adrenergic reresin datanot shown ; . After adsorpthe release of insulin from the pancreas, the secretion of water ceptor adsorption to the from the intestine, and therelease of neurotransmitters from tion, the resin was washed sequentially using digitonin-conpresynaptic terminals in the central and peripheral nervous taining Hepes' buffers to which were added 500 mM NaCl M M system. Although activation of a2-adrenergic receptors is wash buffer A ; , 250 m NaCl wash buffer B ; and 150 m linked to inhibition of adenylate cyclase, there isconsiderable NaCl wash buffer C ; . These washes were intended to remove evidence to suggest that decreases in CAMP alone cannot nonspecifically adsorbed proteins. When fluorescamine assay account for the diversified cellular responses produced by az- of eluted protein indicated that the protein concentration adrenergic receptors cf Ref. 1for a review ; . Recent findings ' Portions of this paper including "Materials and Methods, " part demonstrate that a2-adrenergicreceptors evoke platelet secreof "Results, " and Figs. 4-6 are presented in miniprint at the end of tion via a pathway involving Na + H exchange and accelerate this paper. Miniprint is easily read with the aid of a standard Na + H exchange in the NG108-15 neuroblastoma x glioma magnifying glass. Full size photocopies are available from the Journal cell 2, 3 ; . These data suggest the possibility that az-adrener- of Biological Chemistry, 9650 Rockville Pike, Bethesda, MD 20814 and entecavir.
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