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More than half of the world's population will be living in urban areas by 2008, according to the annual State of World Population 2007 issued by the United Nations Population Fund in June. Most of this growth will occur in Africa and Asia, where urban populations are projected to double between 2000 and 2030. The expansion spurt will be among young people in developing cities, the report says, with inhabitants under age 25 making up more than half the total. Today, one billion people live in slums, 90 percent of them in the developing world. Healthcare, poverty and gender equality are also lacking in many of these same areas. The report maintains that the only way to solve the expanding crisis is for developing nations to act now to ensure the rights of the poor. Here is a look at some of the numbers that are contributing to this trend.
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Acting as a carrier for fatty acids and several amphiphiles from bloodstream to tissues, and hence is an appropriate choice of protein for a study of interaction with amphiphilic drugs. The binding of the drugs to albumin has important effects in their transport to tissues and to the kidneys, where they are cleared from the blood, and on their effective therapeutic concentration. In the present study we have examined the protein binding of two penicillins with amphiphilic structures, cloxacillin and dicloxacillin. Our previous studies of the solution properties of a large number of penicillins6-11 have characterized their selfassembly in aqueous solution as a function of electrolyte content and temperature. Cloxacillin and dicloxacillin are structurally similar, differing only in an additional chlorine atom on the phenyl ring of dicloxacillin see below, Chart 1 ; . They are anionic with pKa's of 2.7 and 2.8, respectively, and will be fully ionized at the pH of the present study. Static light scattering and NMR studies6 have shown that both drugs form small aggregates dimers and trimers ; at a well-defined critical aggregation concentration cac ; in aqueous solution, but there is evidence from both techniques of a second critical concentration in solutions of dicloxacillin but not cloxacillin ; , the NMR technique suggesting a structural rearrangement and light.
DISTRICT OF COLUMBIA HEALTHCARE ALLIANCE BRAND TO GENERIC 07 05 01 * BRAND NAME CORTISPORIN OTIC SUSP COTAZYM CAP COUMADIN 2.5MG TAB COUMADIN 5MG TAB CUPRIMINE 250MG CAP CYCLOGYL 1% OPTH DROPS CYCLOMYDRIL OPTH SOLUTION CYTOMEL 25MCG TAB DALMANE 15MG CAP DAPSONE 100MG TAB DAPSONE 25MG TAB DARAPRIM 25MG TAB DECADRON 0.5MG TAB DECADRON 4MG TAB DELFEN FOAM 12.5% VAGINAL DELTASONE 20MG TAB DELTASONE 5MG TAB DEMEROL 50MG TAB DEPAKENE 250MG CAP DIAMOX 250MG TAB DIAMOX SEQUELS 500MG DIDRONEL 200MG TAB DILANTIN 100MG CAP DILANTIN 125MG 5ML SUSP DILANTIN 50MG TAB DILAUDID 2MG TAB DITROPAN 5MG TAB DIULO 5MG TAB DULCAGEN 10MG SUPP DYNAPEN 62.5MG 5ML SUSP E.E.S 250MG FILMTAB E.E.S. 200MG 5ML SUSP ELAVIL 10MG TAB ELAVIL 25MG TAB ELAVIL 50MG TAB ELIMITE 5% CREAM ELIXOPHYLLIN 80MG 15ML EL ESIDREX 25MG TAB ESIDREX 50MG TAB ESKALITH 300MG CAP FELDENE 10MG CAP FELDENE 20MG CAP FERROUS SULF 325MG TAB UD FIORINAL TAB FLAGYL 250MG TAB FLEXERIL 10MG TAB FLORINEF 0.1MG TAB FLOVENT 110MCG INHALER GENERIC NAME NEOMYC POLYM B HC OTIC SU PANCRELIPASE CAP WARFARIN SODIUM 2.5MG TAB WARFARIN 5MG TAB PENICILLAMINE 250MG CAP CYCLOPENTOLATE 1% OPTH DR CYCLOPENTOL PHENYLEPH OPT LIOTHYRONINE 25MCG TAB FLURAZEPAM 15MG CAP DAPSONE 100MG TAB DAPSONE 25MG TAB PYRIMETHAMINE 25MG TAB DEXAMETHASONE 0.5MG TAB DEXAMETHASONE 4MG TAB DELFEN FOAM 12.5% VAGINAL PREDNISONE 20MG TAB PREDNISONE 5MG TAB MEPERIDINE 50MG TAB VALPROIC ACID 250MG CAP ACETAZOLAMIDE 250MG TAB ACETAZOLAMIDE 500MG CAP S ETIDRONATE 200MG TAB PHENYTOIN 100MG CAP PHENYTOIN 125MG 5ML SUSP PHENYTOIN 50MG TAB HYDROMORPHONE 2MG TAB OXYBUTYNIN 5MG TAB METOLAZONE 5MG TAB BISACODYL 10MG SUPP DICLOXACILLIN 62.5MG 5ML ERYTHROMYCIN 250MG FILMTA ERYTHROMYCIN 200MG 5ML SU AMITRIPTYLINE 10MG TAB AMITRIPTYLINE 25MG TAB AMITRIPTYLINE HCL 50MG TA PERMETHRIN 5% CREAM THEOPHYLLINE 80MG 15ML EL HYDROCHLOROTHIAZIDE 25MG HYDROCHLOROTHIAZIDE 50MG LITHIUM CARBONATE 300MG C PIROXICAM 10MG CAP PIROXICAM 20MG CAP FERROUS SULF 325MG TAB UD BUTALB 50 CAFF 40 ASA 325 METRONIDAZOLE 250MG TAB CYCLOBENZAPRINE 10MG TAB FLUDROCORTISONE 0.1MG TAB FLUTICASONE PROPIO 110 IN.
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Psoriasis is a common, chronic skin disorder characterized by patches of thick, raised patches of skin, called plaques. The term psoriasis comes from the Greek word "psora" which means "to itch", and itching is the most commonly reported symptom of this disease.249 Many of the complications of psoriasis can lead to difficulties in accomplishing normal daily tasks, such as climbing stairs, housework, gardening, and bathing, translating into substantial reductions in quality of life for patients with this disease.250 In addition to the effects on the skin, individuals with psoriasis may also experience abnormalities of finger or toe nails or burning of the eyes. Individuals with psoriasis are also at an increased risk of developing non-skin related disorders such as inflammatory bowel disease and non-Hodgkin lymphoma.251 Psoriasis may invade the joints, causing a type of inflammation, psoriatic arthritis, which is similar to rheumatoid arthritis.252 In psoriasis, the immune system mistakenly targets the body's own cells, causing skin cells to replenish too rapidly. Overproduction of skin cells causes plaques to form since old skin cells are not able to slough off quickly enough. Though the exact cause of psoriasis is unknown, predisposition for the disease is thought to be genetically inherited, but can also.
In the table above, the column ``Before Non-Recurring Items'' presents financial information before deductions for the nonrecurring items for the prescription drugs, human vaccines, therapeutic proteins, animal health and corporate segments. EBITA is an unaudited non-U.S.-GAAP measurement that we define as operating income loss ; , excluding goodwill amortization, plus equity in earnings from affiliated companies. We have included EBITA information because it is one of the measurements we use to assess our financial performance. However, this measure does not represent cash flows for the periods presented and should not be considered an alternative to net income loss ; as an indicator of our operating performance or as an alternative to cash flow as a source of liquidity. Our EBITA may not be comparable to EBITA as defined by other companies. We believe EBITA is commonly used by financial analysts and others in the pharmaceutical industry. Unaudited and diflunisal.
Balwit, J. M., van Langevelde, P., Vann, J. M., and Proctor, R. A. 1994 ; Gentamicin-resistant menadione and hemin auxotrophic Staphylococcus aureus persist within cultured endothelial cells. J Infect Dis 170: 1033-1037. Barker, C., and Park, S. F. 2001 ; Sensitization of Listeria monocytogenes to low pH, organic acids, and osmotic stress by ethanol. Appl Environ Microbiol 67: 1594-600. Basu, T., and Poddar, R. K. 1994 ; Effect of ethanol on Escherichia coli cells. Enhancement of DNA sysnthesis due to ethanol treatment. Folia Microbiol Praha ; 39: 36. Bateman, B. T., Donegan, N. P., Jarry, T. M., Palma, M., and Cheung, A. L. 2001 ; Evaluation of a Tetracycline-Inducible Promoter in Staphylococcus aureus In.
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Studies sho\dng that users of ecstasy may suffer memory loss, even after discontinuing the drug. Subjects who had ceased using the drug for up to one year demonstrated continued memory impairment. Previous research with monkeys has shown lasting brain study nerve rized toxicity, but this is the first in-depth human of its kind. Prolonged or irreversible damage to transmission vvithin the brain has been theoas a likely result of 'the drug's use.
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CUA 1.S ; ] center of COX and the type 1 cupric site in azurin, stellacyanin, and plastocyanin have about the same values at 16 K, but the slope of the relaxation parameter for the [CUA 1.5 ; . CUA 1.5 ; ] center versus temperature is sharper for [CUA 1.5 ; . CUA l.5 ; ] than for the type 1 sites Brudvig et al., 1984 ; . In conclusion, it is proposed that the fast relaxation for the [CUA 1.5 ; . CUA 1.5 ; ] center results from low-lying states due to formation of dinuclear copper centers in which each copper has a type 1 configuration. The saturation-recovery signals for the samples in Table 1 fit to a double-exponential function. Cross-correlation, spectral diffusion, and forbidden transitions were considered and dismissed. Unable to find another mechanism, we considered a continuous distribution of local sites. A stretched-exponential function fits as well as the double exponential, but the linkage between Eq. 1 and Eq. 2 is not yet specified, nor are the relaxation mechanism s ; . If single exponential is required, the data are explained in terms of a distribution of local sites. Upon freezing, the distribution might be attributed to a distribution of the ligands, the vibrational states, or wobbling, which are sensitive to temperature. Nevertheless, a double or higher exponential has not been ruled out. Further studies are required to find a physical model for a relaxation mechanism in copper complexes.
71. MOORE cont'd ; HE CHECKS HER NAME AGAINST A LIST ON A CLIPBOARD. HE TAKES OUT A BADGE AND SHOWS IT TO HER. ; .You are on Gate twenty-one this morning? MRS. CROFT .that is correct, Sir. MOORE We will be conducting a Security Check. I will be coming through the metal detector in HE CHECKS HIS WATCH ; approximately ten minutes. I will be quote Armed, and carrying a toolkit in which are hidden three potentially lethal or dangerous items. This is a test of the security personnel and of the apparatus under your control. Now. I must caution you that, from that time to this you will be under covert surveillance, and should you attempt to communicate MRS. CROFT I wouldn't. MOORE SHRUGS ; .you've been warned. Now: the guard under your supervision will be graded on the following: ANGLE, INT THE AIRPORT CONCOURSE. PINCUS, DRESSED AS A SECURITY GUARD. STANDING BY A BANK OF PHONES. A YOUNG MOTHER WITH A CHILD COMES UP TO ASK DIRECTIONS OF HIS. HE DIRECTS THEM, AND TOUCHES HIS HAT, AND THEY MOVE OFF. ANGLE EXT, AIRPORT DRIVETHROUGH. AT THE STATIONWAGON. MOORE LEANS IN, AND TAKES A LARGE TOOLCASE OUT OF THE BACK. IN THE B.G. WE SEE MRS. CROFT. FRAN LOOKS UP. FRAN Here they come. MOORE LOOKS IN THE REARVIEW MIRROR. ANGLE HIS POV THE SECURITY TRUCK, PULLING INTO THE DRIVETHROUGH AREA. ANGLE FRAN AND MOORE. AS FRAN LOOKS OUT OF THE WINDOW. STILL STANDING BY THE COFFEETRUCK and dionex.
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It is often claimed that exports based on natural resources have limited potential spillovers for the rest of the economy and therefore have less of an impact on growth. In section 2, we argued that commodity exports may contribute less to growth because they generate fewer dynamic linkages, economies of scale and positive externalities for the rest of the economy. Several empirical studies have suggested that countries rich in natural resources tend to grow more slowly than those with few natural resources. For instance, Sachs and Warner!
TABLE 4 PRICE CHANGES FOR TOP 50 COMMON BRAND DRUGS 2000-2001 N0. OF PRICE CHANGES BETWEEN PERCENT 12 31 2000 & CHANGE 12 31 2001 0.0% 3.2% 4.9% 4.0% 0.0% 13.9% 9.3% 4.0 and dirithromycin
HYALURONIDASE myocrisin a bow molecular pass into the follicle cell layer changes if they were to occur. Only minimal during the time release required of for weight compound ; to and produce chemical hyaluronidase mouse sperm occurs to become is unlike 1973 ; the and
Footnotes * this work was supported in part by the science research promotion fund of the japan private school promotion foundation and grants-in-aid for scientific research 13470493 and for scientific research on priority areas 10178102 from the ministry of education, science, culture, and sports of japan and disulfiram.
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In The Psycho Ward My mother and I argued constantly. One evening as we were shouting at each other in the dining room, I suddenly couldn't stand it any more. There was some silverware on the tablecloth. I picked up a knife and threw it at her, but aiming to miss her, which I did. She cowered in the corner near the kitchen door. "You fucking bitch, you fucking goddamn bitch, I'm gonna kill you, you fucking shit-face bitch, I'm going to kill you!" I threw every knife on the table at her, some of them sharp, most the ordinary, round-end knives for eating. Each time I aimed to just miss her shins. She covered her face with her arms, screamed in that hoarse, animal-like voice she had. I had the impression that, although she didn't know it, and would never admit it to herself or me if she did, she was glad this was happening, and that made me all the more furious. I don't remember if the neighbors called the police first, or if they called Judge Caterson one of our neighbors ; directly, but the next thing I remember he was standing there, in the dining room, a tall, dignified man, trying to calm the situation. He took her aside; they talked for a few minutes. Then he took me aside, and in the nicest possible way told me that my choice was to go to the police station, or else to Grasslands for psychological observation. He may have offered me a third choice, namely, staying with her on the promise that there would be no more knife throwing. But, with her crying, moaning, howling in the den, I immediately told him I'd take Grasslands. A howl went up from her. She pleaded with me not to make that decision. I looked at her ugly tear-streaked face and knew it was the right decision. So, a taxi was called, and I was driven to Grasslands, perhaps ten miles away, on the other side of the Bronx River Valley, up by the two smokestacks I had watched from the top of the cherry tree, and less than a mile from Mayfair Acres. A big U-shaped driveway led into the place, which was a low, official-looking, school-like, prison-like building. I had biked past the entrance years before. Someone behind a desk asked for my name, address, phone number, age. Then I was escorted through a door, down a corridor, into a small room which contained nothing but a large, squarish bathtub. A young guy came in, and in a kind voice, told me to remove all my clothes. He turned on the water in the bath. I hung my clothes on the chair, tried to be friendly with him, asked him why I had to take a bath, and he replied, in an equally friendly manner, that it was the rules, that some people come into the place rather dirty. Also, it was a way of checking for weapons. He sat on a low stool, elbows on knees, hands hanging down, observing me as I washed, responding to my questions. When I was finished, he handed me a towel. Then he gave me a shapeless gray outfit to put on -- pants, shirt, and some sort of slippers -- and led me out of the room, down the corridor, up a flight of stairs, down another corridor, and into a bedroom containing two beds. Another guy was there. He introduced us, said some words pertaining to the day's schedule, and left. I expected bars on the windows, but there was only a screen of thick wire. I talked to my new roommate: he was from Yonkers, perhaps a little older than me. He had tried to kill his wife by stabbing her in the back of her neck. She survived. They put him here. A perfectly ordinary guy, he seemed to me. The day began at six, when one of the warders would knock on the door and say something like, "Up and at 'em." A pail of soap and water and two mops were placed at our door. Each roommate had to mop his side of the room. Then breakfast was served in a little alcove a few doors down the corridor and just across from the ping-pong room. I was introduced to some of and dicloxacillin.
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The stability in the body is estimated by the percentage breakdown to penicilloic acid, y x + y ; %, being 57% for phenoxymethyl penicillin and 31 to 32% for phenethicillin and propicillin. Birner 2 ; also reported high percentage breakdown figures which were in the region 60 to 80% and 30 to 55% for the 4- to 6-h period after administration of phenoxymethyl penicillin and phenethicillin, respectively. Absorption and destruction of oral isoxazolyl penicillins. The pattern of results for the isoxazolyl series Table 2 ; again shows that increased recovery of penicillin in the urine, when comparing oxacillin with its halogenated derivatives, is not only associated with increased total absorption x + y ; but also with increased stability of the compounds in the body. Increased halogenation of the phenyl isoxazolyl side chain has a pronounced effect on stability in the body, the percentage breakdown figures, y x + y ; , being down from 49% for oxacillin to 22% for cloxacillin and 10% for dicloxacillin. The penicilloic acid level in urine after oral administration of dicloxacillin and flucloxacillin is quite low, i.e., 4% of dose. Absorption and destruction of oral aamino penicillins. In the a-amino series, breakdown to penicilloic acid was again seen Table 2 ; , being in the region of 20 to 30% [y x + y ; greater proportion of the dose of amoxycillin appears as penicilloic acid 20 to 25% ; than is the case for ampicillin 7 to 11% ; . This may be associated with the fact that amoxycillin is better absorbed and gives higher concentrations in the body. The results for total absorption x + y ; the 250-mg dose were 84% for amoxycillin and 54% for ampicillin. At the 500-mg dose the total absorption results were lower, namely, 74% for amoxycillin and 33% for ampicillin. However, in this 500-mg experiment, the urine recoveries of amoxycillin 49% ; and ampicillin 26% ; were lower than in an earlier 500-mg experiment crossover with 12 volunteers ; , where respective mean values of 60% and 40% were obtained. With the use of an iodometric method which was a forerunner of the method described in this paper, penicilloic acid recoveries of 14% and 11% were obtained in the earlier experiment, giving total absorption figures x + y ; 74% for amoxycillin and 51% for ampicillin. It is clear that amoxycillin is better absorbed than ampicillin, but, unlike the halogenated isoxazolyl penicillins, it does not have improved stability in the body. Late excretion of penicilloic acids. It was noted that 2 to 9% of the 0- to 12-h penicillin and dobutamine.
Proper storage of dicloxacillin : store dicloxacillin at room temperature 59 to 86degrees read in degrees ; f; 15 to 30 degrees c ; in a tightly-closed container, away from heat, moisture, and light.
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