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The full terms of the proposed mandate, which shall include all provisions necessary to enable the Trustee to fulfil its duties under these Commitments; b ; the outline of a work plan which describes how the Trustee intends to carry out its assigned tasks; c ; an indication whether the proposed Trustee is to act as both Monitoring Trustee and Divestiture Trustee or whether different trustees are proposed for the two functions. 5.1.4 Approval or rejection by the Commission The Commission shall have the discretion to approve or reject the proposed Trustee s ; and to approve the proposed mandate subject to any modifications the Commission deems necessary for the Trustee to fulfil its obligations. If only one individual or institution is approved, Bayer HealthCare shall appoint or cause to be appointed, the individual or institution concerned as Trustee, in accordance with the mandate approved by the Commission. If more than one individual or institution is approved, Bayer HealthCare shall be free to choose the Trustee to be appointed from among the individuals or institutions approved. The Trustee shall be appointed within one week of the Commission's approval, in accordance with the mandate approved by the Commission. 5.1.5 New proposal by the Parties If all the proposed Trustees are rejected, Bayer HealthCare shall submit the names of at least two more individuals or institutions within one week of being informed of the rejection, in accordance with the requirements and the procedure set out in paragraphs 5.1.1 to 5.1.3!
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ACN 0.1% TFA, and separated using a 15-30% ACN 0.1% TFA linear gradient in 30 min at a flow rate of 1 mL min. The standard peptide Dyn A 1-8 porcine; Peninsula Laboratories Inc., Belmont, CA ; was used to determine the elution time. The RIA against Dyn A 1-8 has been extensively characterized 4, 24 ; . Briefly, the Dyn A 1-8 antibody is C-terminally targeted and do not cross-react with Dyn A 1-17 or larger forms of proDyn derived peptides and torsemide.
Time he was struggling with a recently introduced Nomad system. In respect of previous findings of misconduct by the Statutory Committee, we were told that there was an appearance on 21 July 2003 for which he received a reprimand. The facts of that matter were that, following the fire at his premises in the year 2000, Mr Salako experienced an extremely difficult period in attempting to re-establish his business. He was under-insured and ran into considerable debt. He found it very difficult to establish adequate controls on his dispensing. Visits from the police and the Society inspectors during 2001 and 2002 found deficiencies in his handling of controlled drugs. He was warned and given advice about this but deficiencies persisted, resulting in the allegations in the 2003 Notice of Inquiry which concerned dispensing and storage of controlled drugs and shortfalls in the controlled drugs register, and, in addition, a number of dispensing errors. These matters occurred between about January and October 2002. The Statutory Committee on that occasion clearly, in imposing a reprimand, took into account Mr Salako's submissions that he would not seek to own a pharmacy premises again but merely work as a locum pharmacist. We heard he had indeed honoured this pledge to the Statutory Committee and continues to work hard as a locum, sometimes travelling considerable distances, and with no further complaint having been made against him since the time of the early Statutory Committee hearing. In considering this finding of misconduct and how it should affect the sanction in respect of the current matter, we bore the following factors in mind: 1. The current matters occurred in the same time period as the previous matters, that is 2002-2003, in the period after the fire when Mr Salako was having difficulty in reestablishing his business. 2. Since the earlier matter involved deficiencies in the dispensing of controlled drugs, we regarded the current matters as less serious than those earlier matters.
Granulomatosis is characterized by granulomatous vasculitis of the upper and lower respiratory tract, by disseminated vasculitis, and by necrotizing glomerulonephritis.' Clinical involvement of the heart is infrequent and usually takes the form of pericarditis.2 Valvular involvement has not been diagnosed before death but has been described in postportem reports.34 The following case report describes a patient with Wegener's granulomatosis in whom echocardiography revealed aortic valvulitis which resolved with medical therapy and tracleer.
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To the interpretation of experiments characterizing the activity of individual isomers. J Steroid Biochem 22: 589 596. Katzenellenbogen JA, O'Malley BW and Katzenellenbogen BS 1996 ; Tripartite steroid hormone receptor pharmacology: Interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones. Mol Endocrinol 10: 119 131. Kawamura I, Lacey E, Mizota T, Tsujimoto S, Nishigaki F, Manda T and Shimomura K 1994 ; The effect of droloxifene on the insulin-like growth factor-I-stimulated growth of breast cancer cells. Anticancer Res 14: 427 431. Ke HZ, Chen HK, Pirie CM, Simmons HA, Ma YF, Jee WS and Thompson DD 1995a ; Effects of droloxifene on prevention of cancellous bone loss and bone turnover in the axial skeleton of aged, ovariectomized rats. Bone 17: 491 496. Ke HZ, Simmons HA, Pirie CM, Crawford DT and Thompson DD 1995b ; Droloxifene, a new estrogen antagonist agonist, prevents bone loss in ovariectomized rats. Endocrinology 136: 2435 -2440. Keaveney MJ, Klug J, Dawson MT, Nestor PV, Neilan JG, Forde RC and Gannon F 1991 ; Evidence for a previously unidentified upstream exon in the human oestrogen receptor gene. Mol Endocrinol 6: 111115. Kee B, Arias J and Montminy MR 1996 ; Adaptor-mediated recruitment of RNA polymerase II to a signal-dependent activator. J Biol Chem 271: 23732375. Kemp JV, Adam HK, Wakeling AE and Slater R 1983 ; Identification and biological activity of tamoxifen metabolites in human serum. Biochem Pharmacol 32: 2045 2052. King WJ and Greene GL 1984 ; Monoclonal antibodies localize estrogen receptor in the nuclei of target cells. Nature Lond. ; 307: 745749. Kirby TJ, Achorm RWP, Perry HO and Winkelmann RK 1962 ; Cataract formation after triparanol therapy. Arch Ophthalmol 68: 486 491. Kirk J, Syed SK, Harris AL, Jarman M, Roufogalis BD, Stratford IJ and Carmicheal J 1994 ; Reversal of P-glycoprotein-mediated multidrug resistance by pure antioestrogens and novel tamoxifen derivatives. Biochem Pharmacol 48: 277285. Kivinen S and Maenpaa J 1990 ; Effect of toremifene on clinical hematological and hormonal parameters at different dose levels in healthy postmenopausal volunteers: Phase I study. J Steroid Biochem 36: 217220. Klein-Hitpass L, Schorpp M, Wagner U and Ryffel GU 1986 ; An estrogen responsive element derived from the 5 flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cells. Cell 46: 10531061. Klinge CM, Bambara RA and Hilf R 1992 ; Antiestrogen-liganded estrogen receptor interaction with estrogen responsive element DNA in vitro. J Steroid Biochem Mol Biol 43: 249 262. Klinge CM, Traish AM, Bambara RA and Hilf R 1996 ; Dissociation of 4-hydroxytamoxifen, but not estradiol or tamoxifen aziridine, from the estrogen receptor as the receptor binds estrogen response element DNA. J Steroid Biochem Mol Biol 57: 51 66. Knabbe C, Kopp A, Hilgers W, Lang D, Muller V, Zugmaier G and Jonat W 1996 ; Regulation and role of TGF beta production in breast cancer. Ann N Y Acad Sci 784: 263276. Knabbe C, Lippman ME, Wakefield LM, Flanders KC, Kasid A, Derynck R and Dickson RB 1987 ; Evidence that transforming growth factor beta is a hormonally regulated negative growth factor in human breast cancer cells. Cell 48: 417 428. Koh JI, Kubota T, Asanuma F, Yamada U, Kawamura E, Hosoda Y, Hashimoto M, Yamamoto O, Sakai S and Maeda K 1992 ; Antitumor effect of triphenylethylene derivative TAT-59 ; against human breast carcinoma xenografts in nude mice. J Surg Oncol 51: 254 258. Kopp A, Jonat W, Schmahl M and Knabbe C 1995 ; Transforming growth factor beta 2 TGF-beta 2 ; levels in plasma of patients with metastatic breast cancer treated with tamoxifen. Cancer Res 55: 4512 4515. Korach KS, Couse JF, Curtis SW, Wasburn TF, Lindzey J, Kimbro KS, Eddy EM, Migliaccio S, Snedeker SM, Lubahn DB, Schomberg DW and Smith EP 1996 ; Estrogen receptor gene disruption: Molecular characterization and experimental and clinical phenotypes. Recent Prog Horm Res 51: 159 186. Krishnan AV, Starhis P, Permuth SF, Tokes L and Feldman D 1993 ; Bisphenol-A: An estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinology 132: 2279 2286. Kristensen B, Ejlertsen B, Dalgaard P, Larsen L, Holmegaard SN, Transbol I and Mouridsen HT 1994 ; Tamoxifen and bone metabolism in postmenopausal low risk breast cancer patients: A randomized study. J Clin Oncol 12: 992997. Krust A, Green S, Argos P, Kumar V, Walter P, Bornert JM and Chambon P 1986 ; The chicken oestrogen receptor sequence: Homology with v-erbA and the human oestrogen and glucocorticoid receptors. EMBO J 5: 891 897. Kuiper GG and Brinkmann AO 1994 ; Steroid hormone receptor phosphorylation: Is there a physiological role? Mol Cell Endocrinol 100: 103107. Kuiper GG, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S and Gustafsson J-A 1997 ; Comparison of ligand binding specificity and transcript tissue distribution of estrogen receptor a and b. Endocrinology 138: 863 870. Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S and Gustafsson J-A 1996 ; Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 93: 59255930. Kumar V and Chambon P 1988 ; The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer. Cell 55: 145156. Kumar V, Green S, Stack G, Berry M, Jin J-R and Chambon P 1987 ; Functional domains of the estrogen receptor. Cell 51: 941951. Kumar V, Green S, Staub A and Chambon P 1986 ; Localization of the estradiol binding and putative DNA-binding domains of the estrogen receptor. EMBO J 5: 99319936. Kurokawa R, Soderstrom M, Hsrlein AJ, Halachml S, Brown M, Rosenfeld MG and Glass CK 1993 ; Polarity-specific activities of retinoic acid receptors determined by a co-repressor. Nature Lond. ; 377: 451 454. Kwok RP, Lundblad JR, Chrivia JC, Richards JP, Bachinger HP, Brennan RG, Roberts SG, Green MR and Goodman RH 1994 ; Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature Lond. ; 370: 223226 and trandolapril.
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27 Every single study, forming part of this thesis, was analysed as it appears in the respective paper I-VI ; . The analytical strategy has been a form of " pattern-matching" 158 ; . By this is meant the comparison of an empirically based pattern with a predicted one. In papers I, II, III, IV, both bio-medical and psychogenetic psychosocial models have served as patterns, in paper VI only a bio-medical one, and in paper V a systemic model, " total building performance" was used. In this framework section of the thesis, the studies are treated jointly as a comprehensive multiple-case study 158 ; , that is, as a collective casework 161 ; . The analytical strategy remains unchanged, basically utilising three patterns and triac.
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Tified as a Tobacco Treatment Specialist after gaining proficiency in brief motivational interviewing and treating tobacco dependence & withdrawal. The CNS moved to standardize tobacco use questions in all nursing assessment forms in order to provide an effective prompt for referrals to the program. Multiple channels were established for making referrals, i.e., email, in-person, and electronic order system. Electronic initial assessment and treatment forms were created as part of the patient's medical record. To facilitate proper use of smoking cessation pharmacotherapies, guidelines were developed and distributed to providers and integrated into the electronic medication ordering system. The program staff created educational materials tailored to tobacco-dependent cancer patients and their families and placed them in all clinics. Each year, referrals to the Smoking Cessation Program have steadily increased, with 875 referrals made in 2005. The majority of referrals have come from the Thoracic 30% ; , Head & Neck 14% ; , and Breast 10% ; services. As the program needs grew, a Nurse Practitioner joined the team to assist with pharmacotherapy and referrals. The oncology CNS and NP play key roles on the frontlines in providing treatment to cancer patients and their families and in providing in-service training and grand rounds presentations. Currently underway are efforts to document the efficacy of the program, examine the efficiency of the referral process, identify patient characteristics influencing cessation success, and generate ideas for program improvement and triazolam.
Nuclear localization of Tyk2 found in the nucleus 52 ; . Some of these represent culmination of cytoplasmic events, as is the case for the translocated STATs, but it will be important to establish whether tyrosine phosphorylation cascades involving JAK kinases can occur within the nucleus.
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