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Hermann, Petra M., Robert P. J. de Lange, Anton W. Pieneman, Andries ter Maat, and Rene F. Jansen. Role of neuropeptides encoded on CDCH-1 gene in the organization of egg-laying behavior in the pond snail, Lymnaea stagnalis. J. Neurophysiol. 78: 28592869, 1997. Egg laying in the pond snail Lymnaea stagnalis is triggered by a discharge of the neuroendocrine caudodorsal cells CDCs ; . The CDCs expresses three different caudorsal cell hormone CDCH ; genes. This gene family expresses, in total, 11 different peptides among which is the ovulation hormone. Besides the CDCs, the CDCH gene family is expressed in other central and peripheral neurons. In this study, we investigated the roles the different CDCH peptides play in the organization of egg-laying behavior. Egg-laying behavior is a sequence of stereotyped movements in which three phases can be distinguished: resting, turning, and oviposition. We have used the excitation of right pedal N RPeN ; motor neurons as a simple analogue of shell-turning behavior, one of the elements of egg-laying behavior. RPeN motor neurons were inhibited during the resting phase of egg laying but were subsequently excited at the onset of and during the turning phase. The excitatory effect could be evoked by application of beta3-CDCP on RPeN motor neurons in the CNS as well as in isolation but not by the ovulation hormone, alpha-CDCP or Calfluxin, the other CDCH-1 peptides tested. The ovulation hormone itself caused inhibition of RPeN motor neurons. Anti-CDCH1 positive fiber tracts were found close to the cell bodies and axons of the RPeN motor neurons. Electrical stimulation of a nerve that contains these fibers resulted in excitation of the RPeN motor neurons. The effects of injection of CDCH-1 peptides into intact animals correlated well with the effects of these peptides on RPeN motor neurons. Injection of beta3-CDCP or alpha-CDCP into intact animals resulted in immediate turning behavior in the absence of egg laying itself. The ovulation hormone and Calfluxin had no immediate effect on the behavior. Furthermore, our data indicate that the individual CDCH-1 peptides act on different targets.
Comments 0 ; 42 blinks blink it temodar temozolomide ; shared by ylinks on dec 20, 2005 via source url information on the oral chemotherapeutic agent used to treat adult patients with refractory anaplastic astrocytoma.
FIG. 3. Peptide maps of MAG immunoreactive products. Peptide maps of the two MAG immunoreactive translation products were obtained by the method of Cleveland et al. 1977 ; and analyzed by autoradiography. The 72-kDa 72 k d ; polypeptide and the67-kDa 67 kd ; polypeptide were synthesized in uitro using 15-day-old brain RNA and 62-day-old brain RNA, respectively, immunoprecipitated, and incubated with various concentrations of V8 protease. Lanes E, C, and D, peptide maps obtained from the 72-kDa polypeptide. Lanes E, F, and G, peptide maps obtained from the 67-kDa polypeptide. Amounts of protease used were 0.005 pg lanes E and E ; , 0.025 pg lanes C and F ; , and 0.5 pg lanes D and C ; . Lane A represents molecular weight standards in kilodaltons.
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If you are using SQL pass-through, consider using the LOAD TABLE command to perform the same operation. LOAD TABLE encapsulates the sequence of SAS DATA and PROC steps into an even more powerful technique for gaining maximum performance when loading a new table. The following example demonstrates the same table construction using LOAD TABLE and SQL pass-through.
Newly diagnosed concomitant phase treatment schedule temodar is administered orally at 75 mg m 2 daily for 42 days concomitant with focal radiotherapy 60gy administered in 30 fractions ; , followed by maintenance temodar for 6 cycles!
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A ACCOLATE ACCUPRIL ACCURETIC ACIPHEX ACTIVELLA ACTOS AGENERASE AGRYLIN ALLEGRA ALLEGRA-D ALPHAGAN P ALTACE AMARYL AMBIEN ANDROGEL ARICEPT ARIMIDEX AROMASIN ARTHROTEC ASACOL ASTELIN ATROVENT AURALGAN AVALIDE AVANDAMET AVANDIA AVAPRO AVELOX AVELOX ABC AVONEX AXERT to be deleted 2 1 04; alternative is MAXALT or IMITREX ; * AZMACORT AZOPT B BACTROBAN BENZAMYCIN BETAPACE AF BETASERON BETIMOL BEXTRA BIAXIN BIAXIN XL C CAFERGOT CANASA CARAC CARDIZEM 360 to be deleted 2 1 04; alternative is CARDIZEM LA 360 MG ; * CARDIZEM LA CASODEX CEDAX CEENU CEFZIL CELEBREX CELEXA CELLCEPT CENESTIN CERUMENEX CETROTIDE CIPRO CLEOCIN VAGINAL CREAM CLIMARA COMBIVENT COMBIVIR COMTAN CONCERTA CONDYLOX COPAXONE COREG CORTIFOAM COZAAR CREON CRIXIVAN CUPRIMINE CYCLESSA CYTOVENE CYTOXAN D DANTRIUM DAPSONE DEPAKOTE DEPAKOTE ER DEPAKOTE SPRINKLE DEPO-PROVERA DETROL DIASTAT to be deleted 2 1 04 ; DIFLUCAN DIFLUCAN 150 ORAL DILANTIN DILAUDID DIPENTUM DOSTINEX DOVONEX DURAGESIC E EFUDEX EFFEXOR EFFEXOR XR ELMIRON EMCYT ENTOCORT EC EPINEPHRINE INJECTION EPIVIR EPIVIR-HBV ERGAMISOL ESCLIM ESTRADERM ESTRATEST ESTRATEST HS ESTROSTEP-FE to be deleted 2 1 04 ; EVISTA EVOXAC EXELON F FARESTON FEMARA FEMHRT to be deleted 2 1 04; alternative is PREMPRO ; * FLOMAX FLONASE FLOVENT FLOVENT ROTADISK FLOXIN OTIC FLUOROPLEX FORADIL AEROLIZER FORTOVASE FOSAMAX FULVICIN P G FULVICIN U F G GLEEVEC GLUCAGON H HELIDAC HEXALEN HIVID HYZAAR I IMITREX, all forms INFERGEN INTAL INHALER INTRON A INVIRASE K KALETRA, capsule and solution KEPPRA K-LYTE DS K-LYTE CL K-LYTE CL 50 KYTRIL L LAMICTAL LAMISIL LARIAM LESCOL LESCOL XL LEUKERAN LEVAQUIN LEVBID LEVOXYL LEVSIN LEVSIN-SL LEVSINEX LEXAPRO LIDODERM LIPITOR LOPROX LOTEMAX LOVENOX LUMIGAN LUNELLE LYSODREN M MACROBID MALARONE MAXALT MEPHYTON METADATE CD METADATE ER METHERGINE METROGEL VAGINAL MIACALCIN MIGRANAL MIRAPEX MYCELEX TROCHE MYLERAN MYLOCEL N NARDIL NASACORT NASACORT AQ NASONEX NEUPOGEN NEURONTIN NEXIUM NILANDRON NITROSTAT NIZORAL SHAMPOO NORITATE NORVASC NORVIR NULEV NUTROPIN NUTROPIN AQ NUTROPIN DEPOT NUVARING O OCUFLOX ORTHO EVRA OMNICEF ONE TOUCH GLUCOMETER ONE TOUCH TEST STRIP ORTHO TRI-CYCLEN ORTHO TRI-CYCLEN LO OVIDE OXSORALEN ULTRA OXYCONTIN P PARNATE PEG-INTRON PENTASA PHOSLO PLAN B PLAVIX PLETAL PRANDIN PRAVACHOL PRECOSE PRED MILD PREDNISONE 1MG PREMARIN PREMARIN CREAM PREMPHASE PREMPRO PREVEN PROCTOFOAM HC PROGRAF PROSCAR PROTOPIC PRO VIGIL PULMICORT RESPULES PULMICORT TURBUHALER PULMOZYME PURINETHOL Q QUIXIN R RAPAMUNE REBETOL REBETRON REBIF RELPAX REMERON SOLTAB REMINYL REQUIP RESCRIPTOR RESTORIL--7.5MG DOSE ONLY RETIN-A MICRO RETROVIR RHINOCORT RHINOCORT AQUA RIDAURA RISPERDAL ROWASA S SAIZEN SANDIMMUNE SEREVENT SEREVENT DISKUS SEROQUEL SINGULAIR SONATA SUSTIVA SYNTHROID T TARGRETIN TARKA TAZORAC TEGRETOL XR TEMODAR TESLAC THIOGUANINE1 TOBI TOBRADEX TOPAMAX TOPROL XL TREXALL TRILEPTAL TRI-NORINYL TRIZIVIR U ULTRASE ULTRASE MT UNIRETIC URECHOLINE URSO V VALCYTE VALTREX VEPESID VERELAN VESANOID VIAGRA VIDEX VIDEX EC VIRACEPT VIREAD VIVELLE VIRAMUNE VISICHOL VOLMAX VOLTAREN OPTHALMIC SOLUTION W WELLBUTRIN SR X XALATAN XELODA XENICAL Y YASMIN 28 Z ZADITOR ZAROXOLYN ZERIT ZIAGEN ZITHROMAX ZOFRAN ZOLOFT ZONEGRAN to be deleted 2 1 04 ; ZOVIRAX TOPICAL ZYBAN ZYPREXA * A therapeutic equivalent is listed as an option. Please consult with your physician.
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Ical trials eg, pregnant women and children ; can affect the economic efficiency of antibacterial therapy.15 Pharmacoeconomic evaluations that account for these factors can help determine the best choice of therapy and demonstrate the economic effects of different treatment strategies in these less than ideal situations. TYPES OF PHARMACOECONOMIC ANALYSES Pharmacoeconomic evaluations of specific therapies may be based on one of two approaches: Direct observation of relevant economic outcomes eg, costs, hospital length of stay ; associated with the treatment under evaluation versus a comparator Modeling of expected economic outcomes based on observed clinical outcomes associated with the specific treatments and known relationships between clinical and economic outcomes from other sources. Four types of pharmacoeconomic evaluation are typically used to assess the costs and consequences of drug therapy--cost-minimization, cost-benefit, costeffectiveness, and cost-utility analyses. These analyses differ in the outcome measures used, as detailed in the sidebar above. Cost-effectiveness and cost-minimization analyses are the most commonly used analysis types for assessing antibacterial drugs. All four of these types of analysis may be based on and teniposide.
In this multicenter trial of 573 patients, significant improvements in overall survival were observed in patients who were treated with temodar in combination with radiotherapy.
| Temodar vs avastinUSE OF METEOROLOGICAL FORECASTS IN FINANCIAL RISK MODELS C. Ziehmann 1, 2 ; , A. Brix 1 ; and S. Jewson 1 ; 1 ; Risk Management Solutions Ltd., 10 Eastcheap, London EC3M 1AJ, UK, 2 ; Potsdam University, Institut fuer Physik, D-14415 Potsdam, Germany. stephon.jewson riskinc Stochastic models of climate variability are used extensively in financial and insurance modelling. Financial transfer functions are generally non-smooth and non-linear, and hence very large 10k ; ensembles are required to achieve reasonable convergence of the predicted distribution of financial outcomes. In certain situations meteorological forecasts can be used to improve these financial predictions. The meteorological components of models for hurricane loss and weather derivative payouts are briefly described, and the issues involved in incorporating both deterministic and ensemble forecasts into these models are discussed. Particular emphasis is placed on three of the major issues that arise in attempting to use available forecasts: a ; correcting for consistent forecast errors b ; merging forecasts with climatological information in optimal ways and c ; creating very large ensembles which are consistent with optimised forecasts on short timescales, and climatology on longer time-scales and tenofovir!
ReceivedMar. 23, 1990: revision accepted Oct. 1, 1990. For reprints contact: Patrick Peltier, Nuclear Medicine, Centre Ren Gau.
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Tween 94 and 285 Hz n 9 ; , well within the CF, range of the tectorial region SO-800 Hz; Fig. 5B ; . The bestevidenceagainstthe possibility that the free-standing hair cellsnormally have CF, values that match their CF, values comesfrom in vivo experiments in which receptor potentials were recordedfrom free-standinghair cellsin response acousto tic clicks and tones Baden-Kristensen and Weiss, 1983; Holton and Weiss, 1983a ; .The in vivo data are generallyconsistentwith a cascademodel of stimulus processing Weiss and Leong, 1985a, b; Weisset al., 1985 ; that placestuning before transduction, implying mechanicaltuning. In particular, in the CF, range l-4 kHz ; the fundamental component of the receptor potential falls off at about 20 dB per decaderelative to the DC component cutoff frequency I 800 Hz ; Holton and Weiss, 1983a ; , indicating a low-passfilter mechanismrather than a resonance. This is true for acousticstimuli largeenoughto saturatethe receptor potential aswell asfor smallerstimuli. Thus, even for the largest receptor potentials which come closestto the large depolarizations that activate the low-frequency electrical resonancein the isolatedcells ; , no electrical resonance the frequency range in of the CF, values is detected in vivo. Another possibility is that cell isolation or whole-cell recording causedexpressionof a high-quality resonance that doesnot normally occur. Two known differences between the circumstances of the free-standing cells in vivo and in our experiments and tequin.
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The character record page shows all the vital statistics and abilities of the selected character. The Character Record is divided between four sections; General, Weapons and Armor, Skills and Feats and Miscellaneous. To access these pages use the buttons at the upper right of the screen. Level Up This button is dimmed until the character gains enough experience points to gain a level. When the player clicks the "Level Up" button, a level up screen will be shown. All changes to the character sheet are highlighted. At this time you will be able to distribute any skill points or feats your character may have gained. A new feat slot requires a new feat to be chosen. Information This page is an in-game help system that will give you detailed information about ability scores, classes, races, skills, and feats. Customize This page allows you to change a character's appearance, voice, biography, or scripts the computer code that controls behaviors reactions to situations ; . Custom Biography: You can customize your character's biography with the Customize button. Simply click on the text and edit it. Export This allows you to save the character's file to your computer for use in other games of Icewind Dale II. The character's current status will be saved, including hit points, experience points, level, class, inventory, etc.
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Shaheen's family has always been in the construction business, and Shaheen started his own flooring business almost 20 years ago with customers like Sears and Wal-Mart. But the entrepreneur wanted to get into a second business in case of a construction business downturn or a slow-down in the economy. The result was Shaheen's first car wash, a 12-bay coin op in Cambridge, Ontario. He says he lucked out finding the right parcel of land in the right location meaning a high traffic area with zoning in place for a car wash. The operation opened about two years ago at Highway 24 and Bishop and has been doing well. "During the time I was building the ; Cambridge car wash ; , I was already looking for another location to build a coin car wash, and this location came up, ' he says, referring to 1227 Appleby Line in Burlington. Originally, Shaheen had planned on duplicating the Cambridge site with another 12-bay coin op. He purchased 1.5 acres of land and created his drawings. But after talking to other operators in the business, he.
A brief statement about benefits follows. Authority under which these benefits are established is located in note I.A. The normal service retirement is at age 65 with 5 years of credited service or when the sum of the member's age and years of credited service equals or exceeds 80 years. Reduced service retirement is at age 55 with 5 years of credited service and any age below 50 with 30 years of credited service. A member is fully vested after 5 years of creditable service and entitled to any benefit for which eligibility requirements have been met. The state of Texas contribution rate was 6.0% for fiscal years 2007, 2006, and 2005. The member contribution rate was 6.4% for fiscal years 2007, 2006, and 2005. These rates are set by state statutes. In certain instances, the reporting entity public school, college, university, medical school or other entity ; is required to make all or a portion of the state's and or member's contribution. B. CONTRIBUTIONS REQUIRED AND CONTRIBUTIONS MADE Contribution requirements are not actuarially determined but are established pursuant to the following state funding policy: 1 ; The state constitution requires the legislature to establish a member contribution rate of not less than 6% of the member's annual compensation and a state contribution rate of not less than 6% and not more than 10% of the aggregate annual compensation of all members of the system during that fiscal year; 2 ; state statute prohibits benefit improvements or contribution reductions if, as a result of the particular action, the time required to amortize TRS' unfunded actuarial liabilities would be increased to a period that exceeds 31 years, or, if the amortization period already exceeds 31 years, the period would be increased by such action and teriparatide.
Asco: temodar temozolomide ; promising for a variety of cancers san francisco, ca - may 15, 2001 - schering-plough research institute today reported results of several investigational studies evaluating temodar® temozolomide ; capsules in a variety of cancers and temodar.
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28 the progression of prostate cancer, although how long that suppression would continue remains tentative because of the early-stage nature of the clinical trial. The two clinical trials reported to date that have used celebrex in the treatment of gliomas combined it with temodar 36 ; or CPT-11 61 ; and are described in the section on chemotherapy. Because of the mild toxicity of NSAIDS, considerable recent research has investigated the mechanisms of its clinical benefit. Whereas initial research focused on the antiangiogenic properties of this class of drugs, several other mechanisms have been identified, including the enhancement of various aspects of the immune system, and inhibition of the genes that prevent damaged cells from undergoing apoptosis. 104 ; . Not all NSAIDS are equal in their anti-proliferative effects, as there is some evidence that one of them, celebrex, is considerably more potent than others in directly inhibiting tumor growth by down-regulating the cyclin proteins regulating the different stages of cell division 105 ; . It is critical to note that many of the mechanisms by which NSAIDS work are strongly involved in the growth of high-grade gliomas, and that the expression of the cyclogenase enzyme that is the target of COX-2 inhibitors correlates strongly with the proliferation rate of glioblastoma tumors and correlates inversely with survival time 106, 107 and thalidomide.
This report illustrates a growing interest in weaving lifelong learning and education with strategies to promote a more coordinated response of governance levels and fostering of positive social capital development. Both the OECD and UNESCO and have played a crucial role in promoting the concept of lifelong learning and its application. Their initiatives during the European Year, and after, have spurred interest and action in lifelong learning in many macro-regional organizations world-wide.
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