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Food consumer ; flu viruses may be developing drug resistance apr 4, 2007 it had been hoped that viruses that developed resistance to neuraminidase inhibitors - the drug class to which oseltamivir tamiflu ; and zanamivir relenza ; belong - would be so weakened by the mutations that make them resistant that they wouldn't be able to spread from person to person.
Frankel and Romer's results have been criticized for two fundamental reasons. Firstly, most currency union members in their sample are poor and small countries. Secondly, estimations are affected by endogeneity bias: it may be the case that countries join currency unions constituted by trade partners. In a more recent paper, using panel data estimators to circumvent the possibility of reverse causality in gravity models, Micco et al [2003] estimate the impact on bilateral trade of European Monetary Union membership. Controlling for European Union membership, they show that affiliation to the EMU has a positive effect on bilateral trade, even if the estimated effect is much smaller than the one estimated by Frankel and Rose.2 This result is particularly interesting, since the EMU is an extreme case of regional integration agreement, which goes far beyond trade policies, and in many respects fulfills the side conditions postulated by Rodrik in order for trade liberalization to be growth enhancing.
1. 2. GlaxoSmithKline UK. Relenza. Summary of Product Characteristics. 2003. Influenza. In: Department of Health. Immunisation against Infectious Diseases. 1996; 113-120. London HMSO. Merchant GL, Mower WR, Talan DA. Update on emerging infections from the Centres for Disease Control and Prevention. Annals of Emergency Medicine 1997; 30: 692-694. National Institute for Clinical Excellence. Guidance on the use of zanamivir Relenza ; in the treatment of influenza. Technology Appraisal Guidance - No. 15. November 2000. National Institute for Clinical Excellence. Guidance on the use of zanamivir, oseltamivir, and amantadine for the treatment of influenza. Technology Appraisal Guidance - No. 58. February 2003. Turner D, Wailoo A, Nicholson K, et al. Systematic review and economic decision modelling for the prevention and treatment of influenza A and B. Assessment report submitted to NICE. April 2002.
Appendix C NATIONAL INSTITUTE FOR HEALTH AND CLINICAL EXCELLENCE Health Technology Appraisal Oseltamivir, amantadine and zanamivir for the prophylaxis of influenza including a review of existing guidance no. 67 ; Response to consultee and commentator comments on the draft scope Comment from AG SCHAAR Population Nature of comment The definitions of "children" differ within the trials of these therapies and in the product licenses. For example, Relenza is licensed for children over 5 yrs, amantadine over 10yrs, oseltamivir over 1yr. Hence the population group "children" should be clarified within the scope. One possibility is to specify an adolescent group but in any event it would be helpful to specify age categories. The population clearly refers to post exposure prophylaxis. But then in the additional questions, seasonal prophylaxis is discussed. Also, the neuraminidase inhibitors marketing authorisations differentiate between PEP 10 days ; and prophylaxis in an epidemic whereas amantadine is 6 weeks for prophylaxis. This issue is also raised in the "other considerations" section. The scope should clarify that it is only concerned with PEP and not long term seasonal ; prophylaxis. In the other considerations section, the scope states that the duration of prophylaxis should be considered as a subgroup analysis. Presumably however, the duration of prophylaxis is guided by the licensed indications and the Institute will only be able to issue guidance on this basis. It should also be noted that our ability to undertake the suggested subgroup analysis Response Guidance will be issued in accordance with the marketing authorisations of each of the three drugs and remicade.
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Acknowledgment. This work is supported by a grant the from the Institute of Agricultural Medicine in Lublin, Poland. Key words: isobolographic analysis, levetiracetam, antiepileptic drugs, maximal electroshock, drug interactions and remodulin
In connection with the preceding article on Podophyllum Laxative, we take pleasure in reproducing, from GLEANER No. 3, long since out of print, the following, contributed at our request by the late Dr. N. M. Dewees, who himself had been a sufferer from diabetes mellitus, and gained much reputation by means of his successful treatment of that disorder.-Ed. PODOPHYLLUM LAXATIVE * AND FRAGRANT SUMACH IN DIABETES In the treatment of diabetes mellitus, there are usually three indications to meet: First, to free the blood of animal or glucose sugar; second, to check the excessive flow of urine, when that occurs; third, to sustain the patient's strength and weight. The treatment is, therefore, divided into medical and dietary. Of the many drugs mentioned in connection with the treatment of this disease, but two have, in my hands, been of any material benefit. These are Fragrant Sumach and Podophyllum Laxative. The first, Fragrant Sumach, is indicated when the flow of urine is excessive, or when the quantity of urine passed in twenty-four hours is considerably above fifty-three ounces. In this condition, the patient usually complains of dry mouth and great thirst, drinking large quantities of water. Many have a disgust for light bread. For this condition give: A Specific Medicine Fragrant Sumach, 3iii to Ki; Glycerin, q.s., ad Kiv. Sig. Teaspoonful every three hours. The smaller dose of Specific Medicine Fragrant Sumach 3iii to Glycerin Kiv ; is usually sufficient, but many times I have increased the quantity to the full dose Fragrant Sumach, Ki Glycerin Kiii ; , and, if necessary to check the excessive flow of urine, would not hesitate to give one teaspoonful of the medicine in water every three hours. In this disease there is a lack of harmony in the function of the glands concerned in the digestion and assimilation of the carbohydrates of the food. To re-establish this harmony, the very best remedy, in my judgment, is Podophyllum Laxative. If the patient is not constipated, one or two teaspoonfuls a day will be enough. If constipated, give a teaspoonful before meals, or more, if needed. When the bowels begin to act, lessen the amount of the remedy taken. This remedy has a most decided action upon the liver and pancreas, but does not sicken the stomach. It will rid the blood of sugar with surprising promptitude. It has done more for me in Addison's disease than any other remedy I have used. I have seen cases where an enormous amount of urine was voided in one night, a sample giving an almost black reaction with Fehling's sugar test. With the treatment outlined above, and without a restricted diet, I have seen this quantity of urine reduced to normal, and without a trace of sugar. I believe, however, that sugar and starch should, as much as possible, be kept out of the bill of fare. The indications and uses of Specific Medicine Fragrant Sumach are, as given on the label, as follows: Specific Medicine Fragrant Sumach, Colloidum Rhus Aromatica ; Specific Use: In renal and urinary affections; painful catarrhal maladies; diarrhea, with profuse and painful discharges; and in some hemorrhages. Dose: A Sp. Med. Rhus Aromatica, 3ss. to 3j. Water, Kiv. Misc. Sig.: A teaspoonful every hour or two. Colloidum Specific Medicine Fragrant Sumach is a remedy used in over-activity of the renal organ, in the absence of active inflammation, and for this purpose has attained a great reputation. Also in diabetes, insipidus and mellitus. The urine is pale, of high specific gravity, the patient debilitated, and there is thirst, chills, and constipation. Few remedies have been so successful in enuresis of children, with chronic urethral or vesical irritation and atony. 'Formerly called "Elixir of Podophyllum.
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Use of Protease Inhibitors in Protease-Naive Patients. Satellite Symposium at the 4th International Congress on AIDS in Asia and the Pacific. Manila, Philippines, October, 1997. Influenza Management in the 21st Century. European Launch of Relenza by GlaxoWellcome. Prague, Czech Republic. November 12, 1999. The Management of Therapeutic Failures-Future Prospects with New Therapeutic Classes. Satellite Symposium at the European Conference on Lipodystrophy and HIV Infection. Marrakech, Morocco. March 25, 2000 New HIV Drugs: Update on Fusion Inhibitors. From Laboratory to Patient: Course in HIV Resistance and Pharmacology. San Francisco, CA, November 9-10, 2001. Future Role of T-20 and Other Fusion Inhibitors. Eighth National Spanish Symposium on HIV Infection, Sitges, Spain, March, 2002. EvoluT-20nary ART: Symbiotic Evolution-Optimizing the Patient Experience with T20. Satellite Symposium at the XIV International AIDS Conference, Barcelona, Spain, July, 2002. Anti-HIV Activity of T-20 and T-1249. IrsiCaixa Foundation: Satellite Symposium at the XIV International AIDS Conference, Barcelona, Spain, July, 2002. National Clinical management of HIV disease. Burroughs-Wellcome Symposium. Update from the Ninth International Conference on AIDS. San Francisco Hilton Hotel, San Francisco, CA, July 14, 1993. Nucleoside analogues in the treatment of advanced HIV disease. Twenty-second Annual Physician Assistant Conference. San Antonio, TX, May 23, 1994. Practical Management of CMV Retinitis. National Conference on Clinical Care of the AIDS Patient. San Francisco, CA, December 8-10, 1994. CMV disease In HIV. University of Washington Harborview Medical Center AIDS Clinical Conference. Seattle, WA, April 12, 1995. Treatment of CMV retinitis: Cidofovir. AmFAR Symposium on Critical Issues in AIDS Research. Washington, D.C., January, 1996. Treatment of acyclovir-resistant HSV with topical cidofovir. Annual meeting of the National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. Washington, D.C., March, 1996. Symposium on new perspectives in the management of ocular manifestations of AIDS
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An ounce of prevention in recent studies, both relenza and tamiflu showed dramatic results in preventing the spread of the flu virus.
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Good sources of folate are dried beans, oranges, and dark green leafy vegetables. Good sources of iron are meat, shellfish, fish, and poultry, iron enriched cereals, lentils and dried beans.
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Was indirectly assessed in parallel experiments by measuring aldosterone secretion Fig. 3, inset ; . At the same concentration 25 M ; , forskolin appeared as potent as AngII 100 nM ; to stimulate steroidogenesis, most probably through activation of the cAMP pathway, which, like calcium, is a well recognized modulator of aldosterone biosynthesis. The same results have been obtained with either 3-isobutyl-1-methyl-xanthine IBMX, 100 M ; , an inhibitor of the cAMP phosphodiesterase, or the cell permeant analog Bu2cAMP 1 mM ; . Thus, it appears that caffeine action on [Ca2 + ]c is not mediated by a change in cAMP levels and restasis.
Effects of the programmes and schemes described in chapter two are explained. Both direct and indirect effects as distinguished in the analytical framework are considered. Section three also deals with the interaction effects of early retirement schemes and alternative routes to retirement. Section 5.4 describes some relevant measures including non-pension related ageing policies ; and reforms that have recently been implemented or are planned to be implemented for the near future. Conclusions based on the strong and weak points of each of the Member States are presented in chapter 7 and relenza.
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Safety Profile of Kv1.3 Inhibitors. A key issue for any long-term therapy is the balance between efficacy and safety. Although suppression of Kv1.3 would appear to provide a good approach to modulate pathologic immune responses mediated by autoreactive TEM cells, Kv1.3 is also present in the central nervous system, kidney, liver, skeletal muscle, platelets, macrophages, testis, and osteoclasts, raising the possibility that Kv1.3 blockers could have adverse side effects. To investigate this possibility, we performed 28-day toxicity studies in rats with PAP1 50 mg kg ; , repeated doses being administered by gavage, and with SL5 repeatedly administered 100 g kg per day or 500 g kg per day ; by daily s.c. injections. Both blockers failed to induce any histopathological changes in any tissue examined, including those reported to express Kv1.3 Table 5, which is published as supporting information on the PNAS web site ; . However, SL5 produced skin irritation at the injection site Table 6, which is published as supporting information on the PNAS web site ; . The blockers did not perceptibly alter blood cell counts or serum chemistry parameters Tables 5 and 6 ; . PAP1 also failed to cause signs of toxicity in treated DP-BB W rats during 10 weeks of therapy. Rhesus macaques administered single doses of Kv1.3 inhibitors PAP1, 3 mg kg i.v.; SL5, 100 g kg i.v. ; did not exhibit toxicity A. A. Ansari, personal communication ; . We previously reported that SL5 and PAP1 exhibit no perceptible in vitro toxicity and were negative in the Ames test 20, 21 ; , and SL5 had no effect on cardiac parameters as measured by continuous EKG monitoring 20 ; . The relative safety of Kv1.3 blockers may be due in part to channel redundancy and also because Kv1.3.
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Aventis CropScience Results Of Operations Aventis CropScience's net sales for the first five months ended May 31, 2002 amounted to S1, 831m. Schering AG's share of profits totaled S45m. 2001 Compared To 2000 Aventis CropScience's net sales amounted to S4, 303m in 2001, an increase of 7% over reported sales of S4, 034m in 2000. After adjusting for the divestment of the household insecticide business in 2001, sales rose 8%. The Crop Protection business segment increased its volume price growth by 6% in spite of a declining world-market. This increase was primarily due to the contributions from the French, Brazilian and Canadian markets and the sustained performance of fast growing products, namely the herbicides Balance and Puma and the insecticide Regent. In the Environmental Science segment, the volume price growth of + 25% was mainly driven by sales growth in the United States. The BioScience business segment reported a sales growth of 9%, mainly due to higher sales in the field seed area. In the United States, which accounted for 18% of Aventis CropScience total sales in 2001, net sales increased 3% to S787m in 2001, compared to S764m in 2000. This sales increase was caused mainly by the Environmental Science business and despite reduced planting acreage and adverse weather conditions, especially during the second-quarter planting season in the Midwest. Net sales in France, which contributed 12% of total sales in 2001, increased 9% to S535m in 2001, compared to 2000 net sales of S491m. This improvement was due to higher sales for industrial crop products, particularly insecticides. In Brazil, the source of 11% of Aventis CropScience's total sales in 2001, net sales rose 16% to S475m in 2001, compared to S409m in 2000, benefiting from higher sales of insecticides and herbicides. In Germany, which accounted for 5% of total sales in 2001, net sales fell 3% to S235m in 2001, compared to 2000 net sales of S243m due to adverse weather conditions and the effects of a major portfolio streamlining. Business in Germany recovered well in the second half of the year. Net sales in Japan, which generated 4% of total sales in 2001, increased to S186m in 2001 from S181m in 2000. After adjusting for currency effects, net sales increased by 13%. The contribution of all other countries rose by 7% to S2, 085m compared to S1, 946m in 2000. Schering AG's share of profits totaled S85m after accounting for goodwill amortization of S24m and remicade.
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