Taxus paclitaxel coated stent
We estimated the inhibitory potency of several SERT antagonists and substrates Table 2, Fig. 3 the five classical SSRIs paroxetine, S-citalopram, sertraline, fluoxetine and fluvoxamine; the highly SERT-selective emissions tomography ligands DASB and IDAM; the TCAs imipramine and desipramine; the SNRI venlafaxine; cocaine and the high-affinity cocaine analog RTI-55; S-citalopram analogues R-citalopram, S-didemethylcitalopram, Lu 33-086-O and Lu 08-052O; an imipramine analog, short imipramine, with a shorter alkylamine chain; dopamine; and finally the substrates MDMA and 5-HT. The relative potencies of antagonists and substrates, comparing gSERT and hSERT, were very similar between uptake and binding inhibition, even though the absolute Ki values for individual compounds differed. The potency for some, but not all, compounds was different comparing gSERT and hSERT and consequently a species-specific rank-order potency profile was established Table 2 ; . The five compounds with the highest potency at hSERT during 5-HT uptake inhibition studies.
Four studies met the inclusion criteria for the costeffectiveness review. In addition, separate submissions were received from Bristol Myers Squibb, GlaxoSmithKline and Schering-Plough Ltd. The review of the economic evidence from the literature and industry submissions identified a number of significant limitations in existing studies assessing the cost-effectiveness of PLDH, topotecan and paclitaxel. A new model was developed to address the limitations identified in these sources and to provide a direct comparison of the full range of possible strategies that are relevant to the NHS. The model explored a range of uncertainties and sources of variability that were not fully addressed in existing data sources. Two separate analyses Analysis 1 and Analysis 2 ; were required in order to reflect the heterogeneity identified in the different trials and the difficulties encountered in obtaining robust estimates using a consistent approach for the methods of evidence synthesis of the relative treatment effects. Analysis 1 assessed the cost-effectiveness of PLDH, topotecan and paclitaxel administered as monotherapies. Sensitivity analysis was undertaken to explore the impact of patient heterogeneity e.g. platinum-sensitive and platinum-resistant refractory patients ; , the inclusion of additional trial data 30-57 ; and alternative assumptions regarding treatment and monitoring costs. In the base-case results for Analysis 1, paclitaxel monotherapy emerged as the cheapest treatment. When the incremental cost-effectiveness ratios ICERs ; were estimated, topotecan was dominated by PLDH. Hence the options considered in the estimation of the ICERs were paclitaxel and PLDH. The ICER for PLDH compared with paclitaxel was 7033 per quality-adjusted life-year QALY ; in the overall patient population comprising platinum-sensitive, -refractory and -resistant patients ; . The ICER was more favourable in the platinum-sensitive group 5777 per QALY ; and less favourable in the platinum-refractory resistant group 9555 per QALY ; . The cost-effectiveness results for the basecase analysis were sensitive to the inclusion of trial 30-57. Incorporating the results of trial 30-57 resulted in less favourable estimates for the ICER.
Vented paclitaxel set
Your doctor should encourage you to be a partner in your medical care and to play an active part in discussing your treatment. Sometimes we may have excellent treatment from caring, committed professionals. However, at other times we may feel our need for information and support are ignored. We need accurate knowledge about drugs and procedures, what choices there are and what the alternatives are if we want to make informed decisions. If your doctor doesn't tell you what you want to know then ask. If you don't understand ask for the information to be explained. If necessary keep asking until you are satisfied that you have all the information you need. If you doctor is not forthcoming or you want to find out more, libraries, the pharmacy, books and, of course, Epilepsy Action, are good sources of information. If you wish to discuss something you have read in an Epilepsy Action booklet or on this site with your doctor, take a copy with you when you go for an appointment. This may help the doctor find out more information. Leave a copy with the doctor and you could be helping other patients with epilepsy too.
To start with, I will present to you a working definition of the compass for orienteering. "The Compass is a direction finding instrument, invaluable as an aid to precise navigation. Its skilful use will allow the orienteer to keep the map oriented, to select more direct routes and follow them faster while maintaining contact with the map."1.
1. Vokes EE, Crawford J, Bogart J, Socinski MA, Clamon G, Green MR. Concurrent chemoradiotherapy for unresectable stage III non-small cell lung cancer. Clin Cancer Res 2005; 11: 5045s Fournel P, Robinet G, Thomas P, Souquet PJ, Lena H, Vergnenegre A, et al. Randomized phase III trial of sequential chemoradiotherapy compared with concurrent chemoradiotherapy in locally advanced non-small-cell lung cancer: Groupe Lyon-Saint-Etienne d'Oncologie Thoracique-Groupe Francais de Pneumo-Cancerologie NPC 95-01 Study. J Clin Oncol 2005; 23: 5910 Furuse K, Fukuoka M, Kawahara M, Nishikawa H, Takada Y, Kudoh S, et al. Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non-small-cell lung cancer. J Clin Oncol 1999; 17: 26929. Curran W, Scott CJ, Langer C, Komaki R, Lee J, Hauser S, et al. Long-term benefit is observed in a phase III comparison of sequential vs concurrent chemo-radiation for patients with unresected stage III NSCLC: RTOG 9410. Proc Soc Clin Oncol 2003; 22: p621 abstr 2499 ; . 5. Sekine I, Noda K, Oshita F, Yamada K, Tanaka M, Yamashita K, et al. Phase I study of cisplatin, vinorelbine, and concurrent thoracic radiotherapy for unresectable stage III non-small cell lung cancer. Cancer Sci 2004; 95: 6915. Vokes EE, Herndon JE, 2nd, Crawford J, Leopold KA, Perry MC, Miller AA, et al. Randomized phase II study of cisplatin with gemcitabine or paclitaxel or vinorelbine as induction chemotherapy followed by concomitant chemoradiotherapy for stage IIIB non-small-cell lung cancer: cancer and leukemia group B study 9431. J Clin Oncol 2002; 20: 4191 Choy H, Akerley W, Safran H, Graziano S, Chung C, Williams T, et al. Multiinstitutional phase II trial of paclitaxel, carboplatin, and concurrent radiation therapy for locally advanced non-small-cell lung cancer. J Clin Oncol 1998; 16: 3316 Kameyama Y, Okazaki N, Nakagawa M, Koshida H, Nakamura M, Gemba M. Nephrotoxicity of a new platinum compound, 254-S, evaluated with rat kidney cortical slices. Toxicol Lett 1990; 52: 15 Furuse K, Fukuoka M, Kurita Y, Ariyoshi Y, Niitani H, Yoneda S, et al. A phase II clinical study of cis-diammine glycolato platinum, 254-S, for primary lung cancer. Gan To Kagaku Ryoho 1992; 19: 87984. Yamamoto N, Tamura T, Kurata T, Yamamoto N, Sekine I, Kunitoh H, et al. Phase I and pharmacokinetic PK ; study of Glycolate-0, 00 ; -diammine platinum II ; Nedaplatin: 254-S ; in elderly patients with non-small cell lung cancer NSCLC ; . Proc Soc Clin Oncol 2000; 19: 203a abstr 792 ; . 11. Nemoto K, Matsushita H, Ogawa Y, Takeda K, Takahashi C, Britton KR, et al. Radiation therapy combined with cis-diammine-glycolatoplatinum Nedaplatin ; and 5-fluorouracil for.
Paclitaxel elisa
Ing cisplatin, measurable as a prolongation of 6 weeks in median survival and an absolute improvement of 6% at 1 year. Although the extent of this advantage is below the threshold that was considered as clinically relevant when the study was planned ie, 9 weeks in median survival ; , it should be noted that survival differences of this magnitude, or even less, have been statistically significant in other trials and have led to changes in treatment strategies in various parts of the world.35, 36 Another trial has been published recently comparing cisplatinto non cisplatin-based chemotherapy.37 In that study of 441 patients, there was no difference between the response rates produced by cisplatin and docetaxel compared with those produced by gemcitabine and docetaxel combinations 35% v 33% ; . As a secondary end point, there was also no difference in survival median, 10 v 9.5 months; 42% v 39% at 1 year ; . Severe neutropenia, vomiting, and diarrhea were more frequent with cisplatin and docetaxel; QoL was not assessed. Some aspects of trial planning, unfortunately, make the results of this study difficult to interpret with respect to its statistical aspects see correspondence relating to37 ; , and the lack of a QoL assessment does not allow interpretation of this crucial matter. Preliminary results of the EORTC trial 0897538 indicate that survival time is shorter with a paclitaxel plus gemcitabine combination as compared with more standard PG and cisplatin plus paclitaxel combinations median survivals, 6.9, 8.8, and 8.1 months, respectively ; . In contrast, in a study conducted by a Spanish cooperative group39 median survivals were similar in the standard arm PG ; and in an experimental arm including sequential doublets of GemVin and ifosfamide plus vinorelbine; in the latter arm, only response rate 24% ; was lower compared with the standard arm 41% ; . A retrospective analysis of a large European study comparing a standard doublet cisplatin and vindesine ; versus an innovative doublet PV ; versus a singleagent treatment with vinorelbine recently indicated that cisplatin-based treatments are not more effective than single-agent vinorelbine in patients with poor performance status.40 However, these data come from a subgroup retrospective analysis and thus should be taken into consideration only to plan future prospective trials. In addition, contrasting evidence has been produced by Socinski et al, 32 who found that prolonged up to eight cycles ; carboplatin and paclitaxel treatment was more effective than shorter four cycles ; treatment only in patients with poor performance status. A definitive agreement on whether cisplatin can be removed from its role as a key drug in the palliative treatment of advanced NSCLC cannot be reached until additional trials are published and, possibly, data are pooled to increase the statistical power of survival comparisons. Our data show that a combination of gemcitabine and vinorelbine is similar to standard cisplatin-based regimens with respect to palliation as assessed by response rate and QoL, and is less toxic, producing statistically significant advantages in several QoL indices that are mostly affected by treatment toxicity vomiting, appetite, and hair loss ; . It should be emphasized, however, that primary analysis of this trial is based on a 2-month observation period; this could be a limitation, although we believe that any analysis beyond this time would be affected by and palonosetron.
Paclitaxel joint pain
Table 13. Study TC9704 Proportion of subjects with a booster response1 to diphtheria toxoid following vaccination with Td, by age group Group N n % 95 % Adults2 Adolescents3.
United States of America -- The manufacturer of trastuzumab Herceptin ; has updated health care professionals on cardiotoxicity information obtained from the National Surgical Adjuvant Breast and Bowel Project NSABP ; study B-31 ; , a randomized, Phase III trial that was conducted in 2043 women with operable, HER2 overexpressing breast cancer IHC 3 + or FISH + ; . This study demonstrated a significant increase in cardiotoxicity in patients who were randomized to the trastuzumabcontaining arm as compared to patients who received chemotherapy alone. Trastuzumab as a single agent is indicated for the treatment of patients with metastatic breast cancer whose tumours overexpress the HER2 protein and who have received one or more chemotherapy regimens for their metastatic disease. Trastuzumab in combination with paclitaxel is indicated for treatment of patients with metastatic breast cancer whose tumours overexpress the HER2 protein and who have not received chemotherapy for their metastatic disease. Trastuzumab should be used in patients whose tumours have been evaluated with an assay validated to predict HER2 protein overexpression. It should be noted that trastuzumab is not indicated for any other patients, including those with newly diagnosed, operable breast cancer. Risk factors for cardiac dysfunction will be analysed with data from both the NSABP B-31 and the North Central Cancer Treatment Group NCCTG N9831 trials, when available and pamidronate.
ITEM NAME mithramycin Plicamycin ; mitomycin inj 2mg IV bladder instillation mitomycin inj 10mg IV bladder instillation mitozantrone as Hcl inj 2mg ml, 10ml vial ; Vinca alkaloids and etoposide etoposide caps 25mg etoposide caps 50mg etoposide caps 100mg etoposide inj 20mg ml, 5ml or 100mg 5ml teniposide inj 50mg 5ml vinblastine sulphate inj 10mg vincristine sulphate inj 1mg vincristine sulphate IV inj 5mg vindesine sulphate inj 5mg vindesine sulphate inj 1mg Vinorelbine as ditartrate IV inj 50mg 5ml vial Vinorelbine as ditartrate IV inj 10mg 1ml vial Enzymes L-asparaginase IM, IV inj 10000 IU IV route with isotonic glucose water or physiological solution ; Miscellaneous agents cisplatin inj 10mg IV infusion intra peritoneal + instillation cisplatin inj 50mg IV infusion carboplatin inj 15mg IV infusion carboplatin inj 50mg hydroxyurea caps 500mg octreotide inj 0.05mg ml octreotide inj 0.1mg ml Paclitaxel inj 30mg vial procarbazine caps 50mg Promod powder Special diet for cancaring patient ; sachet Methyl prednisolon sod. succinate 250 mg vial IM, slow IV, IV infusion Methyl prednisolon s od. succinate 125 mg inj Methyl prednisolon sod. succinate 500 mg inj Pamidronate disodium 15mg vial Pamidronate disodium 30mg vial Di sod chlordronate 400mg cap or tab Di sod chlordronate inj conc IV infusion 60mg ml Somatostatin synthetic ; as acetate I.V inj 250mcg amp Hormones and antagonists aminoglutethimide tab 250mg flutamide scored tab 250mg flutamide cap 250mg flutamide cap 125mg fosfestrol tetrasodium tab 120mg fosfestrol inj 55.2mg ml, 5ml amp ; or fosfestrol tetra sod.60mg ml 5ml amp ; medroxyprogesterone acetate deep IM inj 150mg ml 3.3ml vial ; or deep IM inj 500mg vial medroxyprogesterone acetate tab 100mg medroxyprogesterone acetate tab 250mg tamoxifen tab 10mg tamoxifen tab 20mg anastrozole tablet 1mg DRUGS THAT ALTER IMMUNE RESPONSES azathioprine tab 50mg azathioprine inj 50mg.
Paclitaxel albumin
Document using AdEERS within 10 days a dictated summary and CRF's may also be indicated Institutional reporting as required. DEATH WITHIN 30 DAYS OF COMPLETION OF TREATMENT Telephone report to RTOG within 24 hours of discovery; Follow guidelines outlined in section 7.7 of this protocol for AE reporting. 7.0 DRUG THERAPY 7.1 Treatment Plan 7.1.1 Cetuximab Loading Dose Week 1, Day 1 ; Patients will receive a loading dose of cetuximab C225 ; , 400 mg m, intravenously IV ; over 120 minutes on Day 1. No chemotherapy or radiation therapy will be given this day or week. All patients will be premedicated with diphenhydramine hydrochloride 50 mg or similar agent ; IV 30-60 minutes prior to the first dose of cetuximab in an effort to prevent an allergic hypersensitivity or cytokine release reaction. Premedication is recommended prior to subsequent doses, but at the Investigator's discretion, the dose of diphenhydramine may be reduced. The medical staff must closely observe patients for signs of anaphylaxis or any other potential adverse events. Vital signs blood pressure, heart rate, respiratory rate, and temperature ; should be checked and recorded prior to the administration of cetuximab, midway through the infusion, at the completion of the infusion, and 60 minutes post the infusion in an area with resuscitation equipment and other agents epinephrine, prednisone equivalents, etc. ; available. A nurse must be present in the immediate treatment area throughout the infusion and observation period. A physician must be in close proximity to the patient treatment area. In the event that a patient experiences an allergic hypersensitivity or cytokine release reaction, see Section 7.5.3.1 for proper management. Patients should be instructed to report any delayed reactions to the investigator immediately. Concurrent Cetuximab and Chemoradiation Weeks 2-8 ; [7 26 04] Beginning Day 8, patients will receive weekly treatment with cetuximab 250 mg m IV over 60 minutes before administration of chemotherapy and radiation therapy for 7 weeks see Section 7.2.4 for details of administration ; . Pre-medication with diphenhydramine hydrochloride 50 mg or similar agent ; IV 30-60 minutes is recommended prior to cetuximab administration to prevent an allergic hypersensitivity or cytokine release reaction, but at the Investigator's discretion, the dose of diphenhydramine may be reduced. Following a 30-60 minute observation period after the delivery of cetuximab, patients will receive paclitaxel 45 mg m over 60 minutes and carboplatin AUC 2 over 30 minutes administered weekly for 7 weeks during concurrent RT. If patients have been pre-medicated with diphenhydramine hydrochloride for cetuximab administration, there is no need to pre-medicate patients again prior to paclitaxel infusion. Drug therapy must be administered on either Monday or Tuesday of each week. Consolidation Therapy Weeks 9-17 ; Beginning week 9, following the completion of concurrent cetuximab and chemoradiation, patients will receive three weeks of single agent cetuximab given 250 mg m IV over 60 minutes on a weekly schedule See Section 7.2.4 for details of administration ; . Beginning on week 12 week 4 of consolidation therapy ; , cetuximab administration will be continued weekly at 250 mg m2 IV over 60 minutes. Pre-medication with diphenhydramine hydrochloride 50 mg or similar agent ; IV 30-60 minutes is recommended prior to cetuximab administration to prevent an allergic hypersensitivity or cytokine release reaction, but at the Investigator's discretion, the dose of diphenhydramine may be reduced. Following a 30-60 minute observation period, paclitaxel will be administered at 200 mg m over 3 hours and carboplatin at AUC 6 IV over 30 minutes. The paclitaxel and carboplatin will be delivered every 3 weeks for 6 weeks. If patients have been pre-medicated with diphenhydramine hydrochloride for cetuximab administration, there is no need to premedicate patients again prior to paclitaxel infusion. 19 and papaverine.
Paclitaxel hydrophobicity
3 Summit LBCTs University Medical Center and the Cardiovascular Research Foundation, New York City, and fellow researchers from 37 North American medical centers set out to determine whether the TAXUS drug-eluting stent might offer a better alternative to VBT. Slow release of paclitaxel from the stent's surface has been shown to inhibit new growth of scar tissue in other types of patients, but its effectiveness against in-stent restenosis is unknown. The study enrolled 421 patients with in-stent restenosis, randomly assigning them to VBT or repeat stenting with the TAXUS stent. After 30 days, the two approaches appeared to be equally safe, with similar rates of cardiac death, heart attack, coronary procedures, and blood clotting in the stent. Investigators also evaluated clinical outcomes after nine months of followup, as well as the results of angiography and intravascular ultrasound, two imaging studies that can detect changes in the artery over time. Dr. Stone will present the TAXUS-V ISR study at a Late Breaking Clinical Trials session on Monday, March 13, at 9: 45 a.m. Final Results of the TYPHOON Study, a Multicenter Randomized Trial Comparing the Use of Sirolimus-Eluting Stents to Bare Metal Stents in Primary Angioplasty for Acute Myocardial Infarction Angioplasty and stenting are the most effective ways to open a coronary artery and restore blood flow to the heart after a heart attack, or acute myocardial infarction MI ; . However, it is uncertain whether drug-eluting stents--which have been shown to prevent late arterial renarrowing, or restenosis, in patients with stable coronary artery disease--are suitable for treatment of acute MI. To address that question, investigators from the Trial to Assess the Use of the Cypher Stent in Acute Myocardial Infarction Treated with Angioplasty TYPHOON ; randomly assigned 712 patients who experienced an acute MI to artery-opening treatment with either a bare-metal stent or a Cypher stent. The Cypher stent slowly releases sirolimus, a medication that prevents the overgrowth of scar tissue that can cause restenosis in the months after stenting. Investigators from 48 medical centers participated in the study. To assess the effectiveness and safety of the Cypher stent, investigators have analyzed target vessel failure at one year, as gauged by the need for a procedure to re-open the heart-attack-- more.
A person who is mentally deficient, as a human being and as a patient, is not denied his right to refuse treatment because of his mental illness. Every case must be examined in the light of its circumstances and every patient's decision must be examined in the light of his illness, his condition and fitness at a relevant time. In general, a patient who opts for hospitalization will be given no type of treatment to which he does not agree, except in cases of emergency and parnate!
PREVENTION AND EARLY INTERVENTION PROGRAM FOR PSYCHOSIS PEPP ; , LONDON Based in the London Health Sciences Centre of London, Ontario and affiliated with the University of Western Ontario, PEPP provides comprehensive assessment and treatment for individuals experiencing a first episode of psychosis. Using a modified assertive case management model, the program services ill people between the ages of sixteen and fifty. A clinician is available by phone to handle immediate problems. Appointments with a trained mental health professional can be arranged within twenty-four to forty-eight hours for exploration and assessment of the ill person's situation, either in the clinic, or at the ill person's home. If signs of psychosis or risk for imminent psychosis ; present themselves, a multidisciplinary team of health practitioners will carry out a complete assessment. PEPP is specially designed to suit the needs of youth, and is committed to working in partnership with the families of ill individuals. Hospital admission is avoided whenever possible. Treatment plans are created on an individual case basis, and consist of safe and effective newer antipsychotic medications, combined with psychological and psychosocial interventions. Each individual is carefully monitored by a case manager. Results of the PEPP program confirm those of the EPPIC program in Australia that individuals receiving optimum treatment within six months of onset of psychosis have better recovery than those whose treatment was delayed for six months or more. PEPP recognizes the need to educate the public on early intervention. Their community outreach initiative involves media advertising, strengthening links with community agencies and family physicians, and other interventions designed to facilitate early detection and treatment. PEPP's clinical service is integrated with a research program. Research is focused on the advancement of knowledge about the nature of psychotic disorders, the impact of psychosis on ill people and their families, and the development and evaluation of new approaches to treatment and prevention. Experts in the fields of psychiatry, psychology, epidemiology, economics, neurosciences, nursing, and health services contribute to research projects. One of PEPP's research projects is the evaluation of the effect of its outreach program on the length of time to treatment response, the likelihood of relapse, and the level of improvement in community functioning and quality of life for the ill individual.
Paclitaxel injection indications
Chatham Biotec, Ltd. CBL ; is the supplier of Taxus canadensis biomass based in New Brunswick, Canada. CBL has supplied over 3000 mt of biomass over the past 5 years with good quality and compliance documentation support. Cenway Technologies, Ltd. is a manufacturer of purified paclitaxel API based in Beijing, China. Cenway developed a low-cost HPLC technology for paclitaxel purification and has been in technology cooperation and supply discussions since 2002. CBL and Cenway have now partnered to provide large quantity, compliant, high quality, low cost paclitaxel API for a price of 5-150 us gram based on volume and payment. Compliance and Costs CBL has already prepared relevant documentation regarding harvesting of the biomass for a number of large pharmaceutical companies to satisfy USFDA requirement on biomass. Cenway's manufacturing facility is built under Chinese GMP and has passed preliminary inspection by Chinese State FDA SFDA ; . A Chinese paclitaxel API license is expected in February, 2006. Cenway is close to finishing the preparation for a DMF under USFDA requirement. Cenway can supply such USP26 grade paclitaxel API at a price of 5-150 us gram with a minimum annual purchase quantity. This is based on purchasing biomass with minimum paclitaxel content of 300ppm from CBL at .00 lb .50 us kg and paromomycin.
And older adults may have severe illness. The infection is self-limiting, meaning most people fight off the virus and get better on their own. In rare cases, an acute, intense infection that can lead to liver failure occurs. About half of patients with this rare complication die or require a liver transplant to survive. To prevent exposure to HAV when traveling to the high-risk areas mentioned above, you should: Avoid raw or undercooked food. Avoid cut up fruits and vegetables unless you peeled them yourself. If water safety is a concern, boil all drinking water or treat it with water-purifying tablets. Use boiled, bottled water, or purified water for washing hands and brushing teeth. Avoid beverages with ice. Avoid unbottled beverages. Avoid food from street vendors. Wash hands before each meal! A vaccine is available for Hepatitis A. The vaccine is safe for children and adults. For optimal protection, two doses of the vaccine are required, though a high level of protection is achieved within a month after the first dose. The vaccine is beneficial even when given less than a month before travel. The HAV vaccine can be used to treat people who have been exposed to HAV, in order to prevent the disease from developing. Hepatitis B Hepatitis B virus HBV ; is spread through infected blood and bodily fluids. The virus is found worldwide but it is most prevalent in Africa, Southeast Asia, most of the Middle East, South and West Pacific islands, Mexico and Central America. HBV can cause an acute liver inflammation or chronic infection. Few infected individuals show symptoms and symptoms can take up to six months to develop. Chronic infection may cause slowly progressing liver damage leading to cirrhosis, liver cancer, and premature death.
Paclitaxel mechanism figure
Admit date is missing or invalid. The date of service or Medicare paid date is past the timely filing limit. Medicare allowed or paid equals zero. Place of service missing invalid. Refer to the billing instructions for correct place of service and pbz.
Xyotax paclitaxel poliglumex ; is a new form of paclitaxel that is designed to reduce side effects while maintaining the effectiveness of paclitaxel treatment and paclitaxel.
Weekly paclitaxel herceptin
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Paclitaxel infusion time
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Paclitaxel dosage
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